The major epidemiologic, microbiologic, immunologic, and clinical aspects of Lyme disease that form the basis for a newly developed vaccine that may become available soon for human useImmunology Mini Review Published on 2024-02-142024-09-05 Journal: Frontiers in immunology [Category] update2024, [키워드] alum adjuvant Borrelia burgdorferi clinical trials Lyme disease OspA preventive measure Vaccines [DOI] 10.3389/fimmu.2023.1326623 PMC 바로가기 [Article Type] Immunology Mini Review
Preclinical study of formulated recombinant nucleocapsid protein, the receptor binding domain of the spike protein, and truncated spike (S1) protein as vaccine candidates against COVID-19 in animal models동물 모델에서 COVID-19에 대한 백신 후보로서 제형화된 재조합 뉴클레오캡시드 단백질, 스파이크 단백질의 수용체 결합 도메인 및 절단 스파이크(S1) 단백질의 전임상 연구Article Published on 2022-09-012022-09-11 Journal: Molecular immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] acute respiratory syndrome adjuvants alum alum adjuvant analyzed animal model antibody Antibody titers Antigen AS03 binding candidate vaccine cellular cellular immunity Cellular responses COVID-19 cytokine Cytometry cytotoxicity domain dose doses ELISA evaluated flow cytometry humoral humoral and cellular immunity IgG antibody IgG antibody titer immunization immunization program immunogenic immunogenicity injection mice Mild mild to moderate moderate N-terminal domain not neutralize nucleocapsid protein nucleoprotein pathologic preclinical study primates produced Protein protein antigens RBD Receptor binding domain Receptor-binding domain respiratory SARS-CoV-2 sera Severe acute respiratory syndrome Spike protein Strong Subunit vaccine the spike protein Vaccine vaccine candidate virus Virus neutralization VNT was performed was recorded were used [DOI] 10.1016/j.molimm.2022.06.007 PMC 바로가기 [Article Type] Article
Superoxide Dismutase Prevents SARS-CoV-2-Induced Plasma Cell Apoptosis and Stabilizes Specific Antibody InductionSuperoxide Dismutase는 SARS-CoV-2로 유도된 형질 세포 사멸을 방지하고 특정 항체 유도를 안정화시킵니다Research Article Published on 2022-01-172022-09-12 Journal: Oxidative Medicine and Cellular Longevity [Category] 진단, [키워드] administration alum alum adjuvant apoptotic cell count concurrent coronavirus disease CoV COVID-19 Culture Decline effective element generate heat stress immunization immunized induce induction Infection Maotai mice oxidative stress pathogenic plasma Plasma cell Plasma cells portion prevented promote promoted protein antigens reduced Safe SARS-CoV-2 spike protein Specific specific antibodies specific antibody Spike protein spleen Stress Superoxide treated [DOI] 10.1155/2022/5397733 PMC 바로가기 [Article Type] Research Article
Optimization of SARS-CoV-2 Spike Protein Expression in the Silkworm and Induction of Efficient Protective Immunity by Inoculation With Alum AdjuvantsImmunology Published on 2022-01-122022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] acute respiratory syndrome adjuvant adjuvants Administered alum alum adjuvant antigen-specific antibody approach cartilage coronavirus coronavirus disease COVID-19 COVID-19 pandemic effective Effectiveness efficient Euglena evaluated examined expression expression vector highlight host cells induce induction Infection inoculation mice motif mouse serum neutralizing antibody optimization paramylon produced Protein purified S protein SARS-CoV-2 secreted serum Silkworm-baculovirus expression vector system spike spike (S) protein Spread subunit the S protein therapeutic agents trimeric Vaccine Vaccine development was used [DOI] 10.3389/fimmu.2021.803647 PMC 바로가기 [Article Type] Immunology
An Established Th2-Oriented Response to an Alum-Adjuvanted SARS-CoV-2 Subunit Vaccine Is Not Reversible by Sequential Immunization with Nucleic Acid-Adjuvanted Th1-Oriented Subunit VaccinesArticle Published on 2021-11-012022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] absence acute respiratory syndrome Administered alum adjuvant boost cellular immunity changed coronavirus coronavirus disease COVID-19 CpG demonstrated dose Efficacy eosinophil form Heterologous heterologous boost immunization homogenous boost immunization inactivated induce mice mRNA vaccine nucleic acid adjuvant overcome Pneumonia Prime-boost pulmonary immunopathology question reported response reversed Reversible SARS-CoV-2 SARS-CoV-2 subunit vaccine SARS-CoV-2 vaccine SARS-CoV-2 vaccines subunit Subunit vaccine subunit vaccines Th1 Th1/Th2 orientation Th2 Th2 response Vaccine Vaccines were used [DOI] 10.3390/vaccines9111261 PMC 바로가기 [Article Type] Article
Development of a recombinant vaccine containing a spike S1-Fc fusion protein induced protection against MERS-CoV in human DPP4 knockin transgenic miceArticle Published on 2021-10-302022-11-01 Journal: Journal of virological methods [Category] Coronavirus, MERS, [키워드] addition alum adjuvant antigen-specific neutralizing antibody baculovirus BALB/c mice BSL, biosafety level CEF, chicken embryo fibroblast cells Chinese hamster CHO, Chinese hamster ovary coronavirus demonstrated development Dipeptidyl peptidase-4 DPP4 effective ELISA, enzyme-linked immunosorbent assay Extracellular family Coronaviridae Fc fragment Fc, fragment of crystalline Fragment of crystalline (Fc) molecule fused fusion protein genus Betacoronavirus highly pathogenic human DPP4 humoral immune response Humoral immunity IgG IgG4 immunogenicity inflammatory cell infiltration inoculated lack MERS-CoV MERS-CoV infection MERS-CoV, Middle East respiratory syndrome coronavirus MERS, Middle East respiratory syndrome mice Middle East Middle East respiratory syndrome Coronavirus Neutralizing antibodies PBS, phosphate-buffered saline PBST, phosphate-buffered saline in 0.05 % Tween 20 PCR, polymerase chain reaction PFU, plaque-forming unit Protective Protein Proteins RBD, receptor-binding domain respiratory syndrome coronavirus RLU, relative light unit S1 subunit SARS-CoV, severe acute respiratory syndrome coronavirus secretion SFM, serum-free medium Spike protein therapeutic transgenic mice Vaccine vaccine candidate Vaccine development viral challenge viral outbreak virus [DOI] 10.1016/j.jviromet.2021.114347 PMC 바로가기 [Article Type] Article
α-Hemolysin-Aided Oligomerization of the Spike Protein RBD Resulted in Improved Immunogenicity and Neutralization Against SARS-CoV-2 Variants스파이크 단백질 RBD의 α-헤몰리신 보조 올리고머화로 SARS-CoV-2 변이체에 대한 면역원성 및 중화가 개선됨Immunology Published on 2021-09-242022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] Against alum alum adjuvant Antigen carrier protein Cellular immune response comparable confirmed COVID-19 case conformational conformational epitopes COVID-19 COVID-19 cases cross-protective demonstrated effective Epitopes immunization immunogenicity Improved increase in indicated kDa linear epitopes mHla-RBD molecular weight monomer neutralization activity Neutralizing activity Neutralizing antibodies neutralizing antibody oligomerization Protein pseudovirus Pseudovirus neutralization assay RBD RBD-specific antibodies RBD-specific antibody Safe SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 variants significantly increased specific antibodies Spike protein Subunit vaccine Th2 the RBD the Spike the spike protein Vaccine development Vaccines wild-type virus [DOI] 10.3389/fimmu.2021.757691 PMC 바로가기 [Article Type] Immunology
Inhibition of elastase enhances the adjuvanticity of alum and promotes anti–SARS-CoV-2 systemic and mucosal immunity엘라스타제의 억제는 명반의 면역증강을 강화하고 항-SARS-CoV-2 전신 및 점막 면역을 촉진합니다.423 Published on 2021-08-242022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 진단, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjuvant adjuvanticity alum alum adjuvant antibodies antibody Antibody Response Antibody responses Antigen Blood bloodstream blunt CD4 Cell-mediated immunity coronavirus COVID-19 patients Efficacy Elastase ENhance epitope Epitopes follicular help identify IgA antibodies IgA antibody IL-1 Immunity immunization Immunoglobulin IMPROVE induce inhibition inhibitor injected innate response interleukin investigated lack magnitude mice mucosal mucosal immunity mucosal route mucosal secretion mucosal tissue mucosal tissues myeloid cells neutrophil Neutrophil elastase neutrophil elastase inhibitor Neutrophils pharmacological promote protective antibodies Protective antibody Protein Protein subunit protein-based vaccine recruitment regulate response responses SARS-CoV-2 SARS-CoV-2 spike protein sera Serine serine protease serum antibody serum IgG severe acute respiratory syndrome Coronavirus SIgA Significance Spike protein stimulate subunit Support suppression T cell T cell responses T helper Tfh Th1 Th2 the spike protein vaccination Vaccine Vaccines [DOI] 10.1073/pnas.2102435118 PMC 바로가기 [Article Type] 423
Subunit Nanovaccine with Potent Cellular and Mucosal Immunity for COVID-19COVID-19에 대한 강력한 세포 및 점막 면역을 가진 서브유닛 나노백신Article Published on 2020-09-212022-09-12 Journal: ACS applied bio materials [Category] MERS, SARS, 진단, [키워드] activating acute respiratory syndrome adjuvants alum adjuvant cationic CD4 CD8 cells cellular cellular immunity coronavirus COVID-19 CpG elicit humoral humoral immune response Humoral immunity IgA antibody Immunity infecting inhibit SARS-CoV-2 Liposome mice nanoadjuvant nanovaccine pandemic potent receptor SARS-CoV-2 sera significantly strong T-cell the S1 subunit Vero cells virus [DOI] 10.1021/acsabm.0c00668 PMC 바로가기 [Article Type] Article
Long-term regulation of local cytokine production following immunization in miceArticle Published on 2018-02-282024-09-02 Journal: Microbiology and Immunology [Category] 백일해, 파상풍, [키워드] alum adjuvant G-CSF Inflammatory cytokine monophosphoryl lipid A (MPL). PMC 바로가기