alveolar epithelial cell – Communicable Diseases Research

Micro-patterned culture of iPSC-derived alveolar and airway cells distinguishes SARS-CoV-2 variants

Article

Published on 2024-03-282024-09-05
Journal: Stem Cell Reports [Category] update2024,

Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5

Article

Published on 2022-10-132022-11-15
Journal: Cell [Category] COVID19(2023년), SARS, 진단,

Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cells

Article

Published on 2022-09-212022-11-15
Journal: eLife [Category] 바이오마커, 유전자 메커니즘,

Exploring the Immunomodulatory Aspect of Mesenchymal Stem Cells for Treatment of Severe Coronavirus Disease 19

중증 코로나바이러스 질환 치료를 위한 중간엽 줄기세포의 면역조절 측면 탐색 19

Review

Published on 2022-07-122022-09-11
Journal: Cells [Category] COVID19(2023년), SARS, 치료법,

[키워드] ACE-2 acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus-2 administration affected Alpha alveolar epithelial cell alveolar epithelial cells angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-apoptotic Anti-inflammatory anti-oxidative aspect Asymptomatic average Betacoronavirus breathlessness cause cellular characterized chemokines chest pain Clinical outcome Clinical symptoms colony-stimulating factor coronavirus 2 COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients curative cytokine Cytokine storm Cytokine storms damaged dependent on Deterioration disease severity dry cough Effectiveness Effects elicited endothelial engage enzyme epithelial cells excessive inflammation family Coronaviridae fatigue Fever fibroblast fibroblast growth factor functional GCSF genus genus Betacoronavirus granulocyte granulocyte colony-stimulating factor growth factor Growth factors Health healthy histological IL-6 IL-7 IL-8 IL-9 immune cells immune response immune responses immunomodulation immunomodulatory immunomodulatory capabilities immunomodulatory capability Incubation period individual infected individual infected individuals infiltrating immune cells Inflammatory Inflammatory cytokines inflammatory protein inhalation Injury Intention interferon interleukin intravenous intravenous infusion Invasion IP10 lung Lungs Macrophage majority MCP1 Mesenchymal stem cells MIP1A mitigate monocyte monocyte chemotactic protein-1 MSC MSCs multitude myriad Necrosis organ PDGFB persistence Platelet platelet-derived growth factor positioned positive Protein receptor reduce respiratory Respiratory droplets RNA SARS-CoV-2 SARS-COV-2 infection secretion Secretome Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sore throat STEM stem cell stem cells subunit supportive therapy symptomatic therapeutic therapy tissue TNF-α translational transmitted Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha undergo Vascular virus widespread
[DOI] 10.3390/cells11142175 PMC 바로가기 [Article Type] Review

SARS-CoV-2 Achieves Immune Escape by Destroying Mitochondrial Quality: Comprehensive Analysis of the Cellular Landscapes of Lung and Blood Specimens From Patients With COVID-19

SARS-CoV-2, 미토콘드리아 품질을 파괴하여 면역 탈출 달성: COVID-19 환자의 폐 및 혈액 표본의 세포 환경에 대한 종합 분석

Article

Published on 2022-07-012022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제,

[키워드] activated activating alveolar alveolar epithelial cell alveolar epithelial cells alveolar macrophage Alveolar macrophages analyzed antiviral immunity B cell B cells blocked Blood calcium cell count Comprehensive coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients crossfire cytokine Cytokine storm dataset Defense Degradation energy metabolism epithelial epithelial cell epithelial cells escape exacerbated excessive inflammation explain expression Gene Expression HIF1a Host IFI27 immune immune cells Immune escape Inflammation inhibited Interaction interferon landscape lung tissue Lungs Macrophage macrophages manifestation MCU metabolic pathway metabolism Mitochondria mitochondrial mitochondrial fission mitochondrial functions mitochondrial quality. pathway patients with COVID-19 Perspective plasma pro-inflammatory Regulatory T cell regulatory T cells released Replication respiratory capacity resulting RNA-sequencing SARS-CoV-2 significant changes in Single-cell RNA-sequencing T cells target transformation Tregs type I viral infection
[DOI] 10.3389/fimmu.2022.946731 PMC 바로가기 [Article Type] Article

Protease inhibitor Camostat Mesyalte blocks wild type SARS-CoV-2 and D614G viral entry in human engineered miniature lungs

프로테아제 억제제 Camostat Mesyalte는 인간이 조작한 소형 폐에서 야생형 SARS-CoV-2 및 D614G 바이러스 진입을 차단합니다

Article

Published on 2022-06-012022-09-11
Journal: Biomaterials [Category] Coronavirus, COVID19(2023년), SARS, 치료제,

[키워드] 3D model alveolar alveolar epithelial cell AT2 block camostat catastrophic cell line cell lines COVID-19 Culture D614G develop distal Effect epithelial epithelial cells evaluate Ex vivo highlight human lung in vitro model induce Infection inhibitor involved lentivirus lung lung epithelium maturation moderate organ organ culture organoids pandemic Pathogenesis pathogenesis of COVID-19 phenotype platform pluripotent stem cell Prevent progression Protease inhibitor provided pseudotyped real time reduced Research respiratory tract SARS-CoV-2 SARS-CoV-2 pandemic significantly the SARS-CoV-2 tissue treat type 2 alveolar epithelial cells viral entry viral infection viral infections virulent while wild type wildtype
[DOI] 10.1016/j.biomaterials.2022.121509 PMC 바로가기 [Article Type] Article

SARS-CoV-2 Spike Protein Destabilizes Microvascular Homeostasis

SARS-CoV-2 스파이크 단백질은 미세혈관 항상성을 불안정하게 합니다.

Research Article

Published on 2021-12-222022-09-10
Journal: Microbiology Spectrum [Category] SARS, 유전자 메커니즘, 치료기술,

[키워드] ACE2 ACE2 expression Activation adverse effect adverse effects Affect alveolar alveolar epithelial cell Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Angiotensin II Apoptosis Aspirin bind blunt bradykinin calcium Calcium signaling caspase cause caused Cell Cell signaling cells Coagulopathies complex Concentration contribute contributing to COVID-19 COVID-19 disease decreased expression downregulation dysfunction Effect Endothelial cell endothelial cells Endothelial dysfunction enzymatic activity enzyme epithelial epithelial cells event Evidence exposure expressed Factor homeostasis immunofluorescence microscopy in vitro model increased expression indicated infects Inflammation Interaction Interference Intervention Krüppel limit lung lung tissue lung tissues Lungs mechanism molecules organ dysfunction Pathogenesis pathology primary human cells pro-inflammatory molecules rationale receptor reduce reduced Respiratory function SARS-CoV-2 SARS-CoV-2 infected individuals SARS-COV-2 infection Signaling significantly spike Spike protein suggested tested these cell These cells thought thrombotic Thrombotic events understanding uninfected Vascular viability
[DOI] 10.1128/Spectrum.00735-21 PMC 바로가기 [Article Type] Research Article

The blood-gas barrier in COVID-19: an overview of the effects of SARS-CoV-2 infection on the alveolar epithelial and endothelial cells of the lung

Review

Published on 2021-10-022023-06-19
Journal: Tissue Barriers [Category] MERS,

[키워드] adherens junction alveolar epithelial cell alveolar-capillary barrier Blood-gas barrier Coronavirus disease 2019 COVID-19 Endothelial cell Extracellular matrix severe acute respiratory syndrome coronavirus 2 tight junction
[DOI] 10.1080/21688370.2021.1937013 PMC 바로가기 [Article Type] Review

Microbiota and Its Impact on the Immune System in COVID-19—A Narrative Review

Review

Published on 2021-09-302022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

Targeting purinergic receptors to suppress the cytokine storm induced by SARS-CoV-2 infection in pulmonary tissue

Article

Published on 2021-09-132022-11-01
Journal: International immunopharmacology [Category] COVID-19, MERS, SARS,

[키워드] “cytokine storm” A1, adenosine 1 receptor A2A, adenosine 2A receptor A2B, adenosine 2B receptor A3, adenosine 3 receptor Abstract ACE2 ACE2, angiotensin II-converting enzyme ACh, Acetylcholine Activation acute respiratory syndrome ADA, adenosine deaminase adenosine Ado, adenosine nucleoside ADP, adenosine diphosphate AEC, alveolar epithelial cell AK, adenosine kinase ALP, alkaline phosphatases alveolar epithelial cell AM, alveolar macrophages AMP, adenosine monophosphate APC, antigen presenting cell ARDS, acute respiratory distress syndrome ATP ATP, adenosine triphosphate binding CCL, chemokine ligand with CC motif CD, cluster of differentiation CDC, Centers for Disease Control and Prevention characterized CLR, C-type lectin receptor CNS, Central Nervous System CNT, concentrated nucleoside transporters COPD, Chronic obstructive pulmonary disease coronavirus coronavirus disease cough COVID-19 COVID-19, coronavirus disease CT, Computed tomography cytokine DAMP, danger-associated molecular pattern death Defense difficulty breathing E protein, envelope protein E-5′-NT, ecto-5′-nucleotidase E-NPP, ectonucleotide pyrophosphatase/ phosphodiesterase E-NTPDase, ectonucleoside triphosphate diphosphohydrolase effective ENT, balanced nucleoside transporters enzyme etiological agent expressed FDA, Food and Drug Administration Fever G-CSF, granulocyte colony-stimulating factor GABA, γ-amino butyric acid GVHD, Graft-versus-host disease H1N1, influenza type A subtype H1N1 virus HIF, hypoxia-inducible factor ICTV, International Committee on Taxonomy of Viruses ICU, Intensive care unit IFN-γ, interferon gamma IFN-I, type I interferon IGG, immunoglobulin g IGM, immunoglobulin m IL-1β, interleukin 1 beta IL, interleukin immune immune cells immune system infecting Infection Inflammation Interaction involved IP-10, interferon gamma-induced protein 10 IPF, Idiopathic pulmonary fibrosis Lung disease M protein, membrane protein MCP-1, monocyte chemotactic protein 1 mechanism MERS-CoV, Middle East respiratory syndrome MHC-I, major histocompatibility complex class I MHC-II, major histocompatibility complex class II MIP-1α, macrophage inflammatory proteins 1-alpha modulation N protein, nucleocapsid protein NAc, nucleus accumbens NET, neutrophil extracellular traps NK, natural killer NLRP3, NOD-, LRR- and pyrin domain-containing protein 3 organ P1, type 1 purinergic receptor P2, type 2 purinergic receptor P2X7 pandemic Pneumonia Protein purinergic signaling receptor receptors reduce Replication respiratory tract responsible RNA, Ribonucleic acid ROS, reactive oxygen species RT-PCR, Reverse transcription polymerase chain reaction S protein, spike protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 virus SARS-CoV, severe acute respiratory syndrome coronavirus SARS, Severe acute respiratory syndrome severity Signaling single-stranded RNA virus suppress targeting the Coronaviridae the cytokine storm the disease therapy tissue TNF-α, tumor necrosis factor alpha Treatment Trigger viral surface virus WHO, World Health Organization with COVID-19
[DOI] 10.1016/j.intimp.2021.108150 PMC 바로가기 [Article Type] Article