Robust antiviral activity of commonly prescribed antidepressants against emerging coronaviruses: in vitro and in silico drug repurposing studies신종 코로나바이러스에 대해 일반적으로 처방되는 항우울제의 강력한 항바이러스 활성: 시험관 내 및 실리코 약물 용도 변경 연구Article Published on 2022-07-282022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] activities activity amitriptyline anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Anti-viral antidepressant antidepressants antiviral activity clinical trials coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Depression disorder disorders drug eating disorders effective Efficacy eight evaluated FDA-approved drug FDA-approved drugs FIVE imipramine in silico in vitro in vivo M pro MERS MERS-CoV migraine molecular docking studies Molecular docking study neuralgia pandemic Paroxetine Patient performed Prophylaxis protease reported symptom Result SARS-CoV-2 sertraline suggested symptomatic and asymptomatic symptoms of depression treating COVID-19 Treatment [DOI] 10.1038/s41598-022-17082-6 PMC 바로가기 [Article Type] Article
A Combination of Indomethacin Farnesyl and Amitriptyline Is Effective for Continuous Interictal Pain with Probable Chronic Paroxysmal HemicraniaCase Report Published on 2021-06-262024-09-04 Journal: Internal medicine (Tokyo, Japan) [Category] 대상포진, [키워드] amitriptyline chronic paroxysmal headache indomethacin farnesyl interictal pain migraine [DOI] 10.2169/internalmedicine.7511-21 PMC 바로가기 [Article Type] Case Report
Ex vivo assay to evaluate the efficacy of drugs targeting sphingolipids in preventing SARS-CoV-2 infection of nasal epithelial cells비강 상피 세포의 SARS-CoV-2 감염 예방에 있어 스핑고지질을 표적으로 하는 약물의 효능을 평가하기 위한 생체 외 분석Article Published on 2021-03-192022-08-31 Journal: STAR protocols [Category] MERS, SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 amitriptyline antidepressant approved assays Cell isolation Cell-based assays. Complete Coronavirus-2 COVID-19 drug drugs targeting Efficacy epithelial cell epithelial cells evaluate Ex vivo Infection infection level infection levels inhibitor nasal epithelial cell offer Particle presenting protocol quantified Replication respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus sphingolipid Spike protein stomatitis the SARS-CoV-2 vesicular stomatitis vesicular stomatitis virus Volunteer were infected [DOI] 10.1016/j.xpro.2021.100356 PMC 바로가기 [Article Type] Article
Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial CellsArticle Published on 2020-10-292023-07-01 Journal: Cell Reports Medicine [Category] SARS, [키워드] acid sphingomyelinase amitriptyline antidepressants ceramide escitalopram Fluoxetine human nasal epithelial cells Infection SARS-CoV-2 [DOI] 10.1016/j.xcrm.2020.100142 PMC 바로가기 [Article Type] Article
A Dual Noradrenergic Mechanism for the Relief of Neuropathic Allodynia by the Antidepressant Drugs Duloxetine and AmitriptylineResearch Article Published on 2018-11-142024-09-04 Journal: The Journal of Neuroscience [Category] 대상포진, [키워드] amitriptyline antidepressants Duloxetine neuropathic pain TLR2 TNF-α [DOI] 10.1523/JNEUROSCI.1004-18.2018 PMC 바로가기 [Article Type] Research Article
An Evaluation of Efficacy and Safety of Commonly Prescribed Drugs and Effect of These Drugs on Quality of Sleep in Patients Suffering From Zoster-Associated Pain대상포진 관련 통증을 앓고 있는 환자에서 일반적으로 처방되는 약물의 효능 및 안전성 평가와 이러한 약물이 수면의 질에 미치는 영향Observational Study Published on 2018-11-012023-06-02 Journal: Journal of clinical pharmacology [Category] 대상포진, 두창, [키워드] amitriptyline Gabapentin Insomnia Severity Index Neuropathic Pain Scale NSAIDS Wong Baker FACES Pain Rating Scale zoster-associated pain [DOI] 10.1002/jcph.1255 [Article Type] Observational Study
Adverse Effects of Antidepressants for Chronic Pain: A Systematic Review and Meta-analysisOriginal Research Published on 2017-07-142024-09-02 Journal: Frontiers in Neurology [Category] 대상포진, [키워드] amitriptyline antidepressants chronic pain Fluoxetine nortriptyline Safety Side effects venlafaxine [DOI] 10.3389/fneur.2017.00307 PMC 바로가기 [Article Type] Original Research
The use of neuralgia medications to treat sensory neuropathic cough: our experience in a retrospective cohort of thirty-two patientsarticle Published on 2015-03-032024-09-02 Journal: PeerJ [Category] 대상포진, [키워드] amitriptyline cough Desipramine Gabapentin neuralgia Sensory neuropathy Treatment [DOI] 10.7717/peerj.816 PMC 바로가기 [Article Type] article
Topical glycopirrolate for the management of hyperhidrosis in herpetic neuralgia헤르페스 신경통에서 다한증 관리를 위한 국소 글리코피롤레이트Case Reports Published on 2009-04-302023-06-03 Journal: Yonsei medical journal [Category] 대상포진, 두창, [키워드] amitriptyline glycopirrolate herpes zoster hyperhidrosis. [DOI] 10.3349/ymj.2009.50.2.293 PMC 바로가기 [Article Type] Case Reports