Maternal plasma angiotensin 1-7 concentration is related to twin pregnancy chorionicity in the third trimester of pregnancyEndocrinology Original Research Published on 2024-01-082024-09-05 Journal: Frontiers in Endocrinology [Category] update2024, [키워드] Angiotensin 1-7 Angiotensin II dichorionic monochorionic twin pregnancy [DOI] 10.3389/fendo.2023.1329025 PMC 바로가기 [Article Type] Endocrinology Original Research
A randomized, placebo-controlled, double-blinded pilot study of angiotensin 1-7 (TXA-127) for the treatment of severe COVID-19Randomized Controlled Trial Published on 2022-07-282022-10-05 Journal: Critical Care [Category] 임상, [키워드] Angiotensin 1-7 double-blinded pilot study placebo-controlled Randomized severe COVID-19 Treatment [DOI] 10.1186/s13054-022-04096-9 PMC 바로가기 [Article Type] Randomized Controlled Trial
The Identikit of Patient at Risk for Severe COVID-19 and Death: The Dysregulation of Renin-Angiotensin System as the Common ThemeReview Published on 2021-12-152022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome adverse outcome Ang II Angiotensin 1-7 Arm Arterial hypertension binding cardiovascular disease cardiovascular morbidity caused characterized common conditions coronavirus coronavirus disease COVID-19 Diabetes Mellitus down-regulation dysregulation Evidence Health hospitalized patients hypertension increased risk Infection Lung injury Male sex metabolic condition metabolic syndrome obesity Older age opposite overweight pandemic pathophysiological Patient phenotype prevalent RAS receptor reducing renin-angiotensin system SARS-CoV-2 severe COVID-19 syndrome System traits type 2 diabete virus widespread [DOI] 10.3390/jcm10245883 PMC 바로가기 [Article Type] Review
The soluble catalytic ectodomain of ACE2 a biomarker of cardiac remodelling: new insights for heart failure and COVID19심장 리모델링의 바이오마커인 ACE2의 가용성 촉매 엑토도메인: 심부전 및 COVID19에 대한 새로운 통찰력Review Published on 2021-07-012022-09-11 Journal: Heart failure reviews [Category] MERS, SARS, 바이오마커, [키워드] ACE2 angiotensin Angiotensin 1-7 Angiotensin-converting enzyme angiotensin-converting enzyme 2 biochemical Biomarker body fluids cardiac remodelling cardiovascular disease catalytic chelation Chelation therapy COVID-19 COVID-19 infection COVID19 ectodomain Evidence function heart failure Increasing Local lung Lung injury membrane molecular plasma potential therapy Protective provided regulate Renin renin-angiotensin system SARS-CoV-2 soluble ACE2 soluble catalytic ectodomain of ACE2. tissues transmembrane protein type I [DOI] 10.1007/s10741-020-10066-6 PMC 바로가기 [Article Type] Review
Angiotensin-(1-7)—A Potential Remedy for AKI: Insights Derived from the COVID-19 PandemicReview Published on 2021-03-132022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] accelerate ACE ACE2 Acute kidney injury administration AKI Ang II Angiotensin 1-7 AT1R characterized Chronic kidney disease CKD condition counteract COVID-19 COVID-19 disease COVID-19 pandemic Cytokine storm Deleterious Diabetic disorder Effects enzyme Evidence fibrosis G protein-coupled receptor hypertensive Inflammation insight Intervention management Mas receptor MOST outcome oxidative stress Potential progression RAAS RAS receptor remedy renal renal damage renal parenchymal damage severe COVID-19 disease Spike protein subsequent suggested target host cells tested therapeutic option triggering vasoconstriction [DOI] 10.3390/jcm10061200 PMC 바로가기 [Article Type] Review
Molecular Mechanisms of Proteins — Targets for SARS-CoV-2 (Review)단백질의 분자 메커니즘 — SARS-CoV-2의 표적(검토)Review Published on 2020-12-282022-09-10 Journal: Modern Technologies in Medicine [Category] MERS, SARS, 치료기술, 치료제, [키워드] accumulating ACE2 Activation Affect affected angiotensin Angiotensin 1-7 Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme 2 astrogliosis basal ganglia blood-brain barrier Brain brain damage brain damage in COVID-19 brain tissue breakdown caused CD147 Central nervous system Cerebellum change CNS coronavirus Coronavirus infection COVID-19 Cytokines damage death develop disease Diseases driven by Endothelial cell endothelial cells enzyme Evidence exposure to expressed Extracellular matrix functional ganglia help hypothalamus inducer Infection information interactions leads leukocyte leukocytes Local massive matrix metalloproteinases mechanisms membrane permeability metabolism microglia midbrain molecular mechanism molecular mechanisms moment nasal epithelium Neuroinflammation neurons Neurovascular New coronavirus new coronavirus SARS-CoV-2 pathogen Pathogenesis pathogenesis of COVID-19 Piriform cortex Proinflammatory cytokine proinflammatory cytokines pulmonary symptoms Research review SARS-CoV-2 Serine serine protease serine protease TMPRSS2 substantia substantia nigra target target proteins the disease TMPRSS2 Treatment Vascular Via virus virus spread [DOI] 10.17691/stm2020.12.6.11 PMC 바로가기 [Article Type] Review
Telmisartan as tentative angiotensin receptor blocker therapeutic for COVID-19Telmisartan, COVID-19에 대한 잠정적 지오텐신 수용체 차단제 치료제Article Published on 2020-11-012022-09-11 Journal: Drug development research [Category] SARS, 임상, [키워드] ACE2 airway alveolar cell alveolar cells Angiotensin 1-7 Angiotensin II angiotensin receptor blocker Apoptosis ARDS binds cascade China clinical trial complex Complication Concentration coronavirus COVID-19 COVID-19 patient COVID-19 patients Cytokines decrease Degradation disease Election endocytosis Epidemic inflammatory process losartan lung membrane protein New coronavirus Open-label pharmacokinetic physiological pro-inflammatory produced proinflammatory cytokines promote Randomized reducing S protein SARS Coronavirus SARS-CoV-2 SARS-CoV-2 virus telmisartan telmisartan. the S protein therapeutic tissue treating COVID-19 patient turn type 2 alveolar cells virus Wuhan [DOI] 10.1002/ddr.21679 PMC 바로가기 [Article Type] Article
COVID-19 susceptibility: potential of ACE2 polymorphismsReview Published on 2020-09-212022-11-01 Journal: The Egyptian Journal of Medical Human Genetics [Category] COVID-19, [키워드] Abstract ACE ACE2 ACE2 receptor activate acute respiratory syndrome ADAM17 addition Ang II Angiotensin 1-7 Angiotensin-converting enzyme association binding binding mechanism blood pressure cleavage coronavirus coronavirus disease COVID-19 Critical enzyme Ethnic groups Extracellular function functional Genetic variant indicate Infection initiate involved metalloproteinase MONITOR motifs outbreak polymorphism RAS receptor Receptor binding Region Regulation Release S-protein sACE2 SARS Coronavirus SARS-CoV SARS-CoV-2 Severe acute respiratory syndrome (SARS) single-nucleotide Single-nucleotide polymorphism (SNP) SNP SNPs soluble ACE2 susceptibility transmembrane serine protease TTSP TTSPs viral entry [DOI] 10.1186/s43042-020-00099-9 PMC 바로가기 [Article Type] Review
Cancer progression in COVID-19: integrating the roles of renin angiotensin aldosterone system, angiopoietin-2, heat shock protein-27 and epithelial mesenchymal transitionShort Communication Published on 2020-09-092022-10-31 Journal: ecancermedicalscience [Category] COVID-19, [키워드] Abnormalities ACE-2 activated Acute inflammation acute respiratory syndrome addition affected Angiogenesis angiopoetin-2 angiotensin Angiotensin 1-7 Anti-inflammatory Apoptosis blood vessel Cancer cancer cell cancer progression cancers cause cell proliferation cells cellular cellular entry Comorbidities coronavirus disease COVID-19 COVID-19 patient Cytokine storm Diffuse alveolar damage disrupt downregulation Effect EMT epithelial Express follow-up study form growth healthcare Heat shock HSP-27 phosphorylation hypothesise immune system induce infections Inflammatory Intussusceptive angiogenesis kidney malignancies Metastasis organ damage outbreak pandemic pathway Pathways Patient Phosphorylation pro-inflammatory progression proliferative Protein RAAS raise receptor responsible risk severe disease survivor susceptibility susceptible the disease tumour upregulated while [DOI] 10.3332/ecancer.2020.1099 PMC 바로가기 [Article Type] Short Communication
Renin-Angiotensin System and Coronavirus Disease 2019: A Narrative ReviewCardiovascular Medicine Published on 2020-08-112022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] 2019 novel coronavirus ACE2 ACE2 mRNA acute respiratory syndrome Angiotensin 1-7 bind cardiovascular damage cardiovascular diseases cardiovascular system caused cells clinical development clinical manifestation coronavirus COVID-19 develop disease downregulation drug epithelial cells expressed expression Heart damage host cell surface hydroxychloroquine/chloroquine interfere Local losartan lung lung alveolar mechanism modulate mRNA expression narrative pandemic Patient patients with COVID-19 pulmonary damage RAS RAS inhibitor RAS inhibitors reduced renin-angiotensin system respiratory symptoms responsible review SARS-CoV-2 System therapy Transmission umifenovir virulence virus [DOI] 10.3389/fcvm.2020.00143 PMC 바로가기 [Article Type] Cardiovascular Medicine