Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity Research Published on 2022-07-252022-10-05 Journal: Nature Immunology [Category] 변종, [키워드] Activation affecting agonist antagonized antiviral immunity Critical deficiency demonstrated deteriorate DNA domain driver expression genetic code identify IFN IFN signaling IFN-I information inhibited Innate innate antiviral immunity Innate immunity interferon IRF3 IRF7 mechanism mice Mortality nucleus occur regulate rescued restored resulting SIRT1 Type I IFN Viral load viral replication [DOI] 10.1038/s41590-022-01269-0 [Article Type] Research
White button mushroom interrupts tissue AR-mediated TMPRSS2 expression and attenuates pro-inflammatory cytokines in C57BL/6 miceArticle Published on 2021-08-022022-10-29 Journal: NPJ Science of Food [Category] COVID-19, [키워드] Activation animal model antagonistic antagonized Asia-Pacific attenuate C57BL/6 Cell chemokines coronavirus Dihydrotestosterone disease European functional host cell Host immune response immune dysregulation implicated Influenza interrupt kidney Lungs mice Nuclear receptors patients pro-inflammatory cytokine Prostate Prostate cancer protease receptor reduce reduced reported serine 2 serum small intestine the United State tissue TMPRSS2 TMPRSS2 expression translational triggering unique white [DOI] 10.1038/s41538-021-00102-6 PMC 바로가기 [Article Type] Article
ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity Research Published on 2021-03-162022-10-05 Journal: Nature Microbiology [Category] SARS, 변종, [키워드] Activation antagonized Antiviral antiviral response caspase caused coronavirus Coronaviruses COVID-19 COVID-19 pandemic domain evade host innate immunity identify IFN response immune evasion Innate immunity interferon ISG15 ISGs MDA5 mechanism Melanoma oligomerization Papain-like protease picornaviruses promote Protein recruitment RIG-I RIG-I-like receptors SARS-CoV-2 the SARS-CoV-2 Trigger upregulating Vaccine Viral RNA viruses [DOI] 10.1038/s41564-021-00884-1 [Article Type] Research
The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptorCoronaviruses Published on 2021-02-272022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] ACE2 ACE2-expressing cell addition antagonized antiviral activity appear bind binding bovine Cell culture cell entry Coronavirus disease 2019 COVID-19 drug candidate effective experiment HCoV-229E HCoV-NL63 HCoV-OC43 heparan sulfate heparin host cell human coronavirus in vitro infect Interaction lack lactoferrin local concentration mechanism of action N-terminal pandemic plasma membrane Proteoglycan recent Remdesivir SARS-CoV-2 SARS-CoV-2 cell shown subsequent synergistic therapeutic interventions therapy viral replication viral spike protein [DOI] 10.1080/22221751.2021.1888660 PMC 바로가기 [Article Type] Coronaviruses
Viral Evasion of RIG-I-Like Receptor-Mediated Immunity through Dysregulation of Ubiquitination and ISGylationReview Published on 2021-01-262022-10-28 Journal: Viruses [Category] COVID-19, [키워드] Activation antagonized Antiviral antiviral responses cellular coronavirus COVID-19 pandemic DNA viruses DUB dysregulation enzyme evade Evidence immune evasion include innate immune response Innate immunity interferon ISG15 knowledge mechanism Pathogenesis pathway post-translational modification Protein regulate Regulation RIG-I-like receptor RLRs RNA virus SARS-CoV-2 Signaling turn type I interferon ubiquitin upregulation Vaccines viral evasion viral pathogen virus infection [DOI] 10.3390/v13020182 PMC 바로가기 [Article Type] Review
Antiviral activity of interleukin-11 as a response to porcine epidemic diarrhea virus infectionResearch Article Published on 2019-12-212022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] activating antagonized Anti-inflammatory Apoptosis caused Cell cytokine diarrhea ENhance epidemic diarrhea epithelial cell expression Factors IL-11 Infection inhibit inhibitor Interleukin-11 intestinal epithelium knockdown mRNA PEDV Phosphorylation physical positively correlated promoted protein level provide Replication signaling pathway significantly STAT3 suppress therapeutic Vero Cell VERO E6 cells viral infection viral infections virus virus infection [DOI] 10.1186/s13567-019-0729-9 PMC 바로가기 [Article Type] Research Article