SARS-CoV-2 ORF3a Protein as a Therapeutic Target against COVID-19 and Long-Term Post-Infection EffectsReview Published on 2024-01-142024-09-05 Journal: Pathogens [Category] update2024, [키워드] antiviral target COVID-19 Cytokine storm High-throughput screening Kidney injury Neuroinflammation ORF3a SARS-CoV-2 viral pathogenesis [DOI] 10.3390/pathogens13010075 PMC 바로가기 [Article Type] Review
Conserved requirement of autophagy-related effectors during coronavirus replicationArticle Published on 2023-02-012023-07-10 Journal: Autophagy [Category] COVID19(2023년), [키워드] antiviral target autophagy coronavirus CRISPR screen host factor. [DOI] 10.1080/15548627.2022.2100617
Acriflavine and proflavine hemisulfate as potential antivirals by targeting MproArticle Published on 2022-12-012022-11-15 Journal: Bioorganic chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] ACF acriflavine activity addition anti-SARS-CoV-2 Antiviral antiviral target BHK-21 cell Compound Coronaviruses demonstrated effective drugs effort enzymatic assay experiment HCoV-OC43 in vitro Infection inhibited inhibitor inhibitors inhibitory activity M pro M(pro) inhibitor MPro Proflavine Proflavine hemisulfate Remdesivir Replication reported SARS-CoV-2 SARS-CoV-2 epidemic SARS-CoV-2 virus Transcription Viral RNA [DOI] 10.1016/j.bioorg.2022.106185 PMC 바로가기
Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virusArticle Published on 2022-10-172022-11-15 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 치료제, [키워드] Activation administration antiviral target cell injury Combination COVID-19 Critical Cytokine storm dependent on drugs facilitate FFA FFAs free fatty acid Host humans IAV Infection influenza A virus inhibitor inhibitors investigated late stage LDs limit Lipid lipid droplet lipolytic lung lung lesion Malnutrition membrane transporter mice mitigate Mortality outbreak pandemic patients pharmacological Proinflammatory cytokine PROTECT reduce Replication replication of SARS-CoV-2 rescued RNA RNA virus SARS-CoV-2 SARS-CoV-2-infected hamsters significantly suppressed therapeutic target Treatment viral infections virus virus-infected cell [DOI] 10.1038/s41392-022-01223-4 PMC 바로가기
Discovery of natural products to block SARS-CoV-2 S-protein interaction with Neuropilin-1 receptor: A molecular dynamics simulation approachArticle Published on 2022-09-012022-11-15 Journal: Microbial pathogenesis [Category] SARS, 유전자 메커니즘, 치료제, [키워드] addition African Analysis Antiviral compound antiviral target approach binding energy calculate Cell cellular entry characterized Compound conformational database demonstrated disrupt distribution expressed feature functional In-vitro inhibitory effect Interaction mechanism of action molecular molecular dynamic simulation Molecular dynamics simulation multiple organ natural natural product Neuropilin-1 NRP1 performed pleiotropic Protein recent S-protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 research screened selected South stability surface receptor the SARS-CoV-2 the SARS-CoV-2 virus Therapeutic approach viral infectivity Virtual screening [DOI] 10.1016/j.micpath.2022.105701 PMC 바로가기
The Possible Role of Prion-Like Viral Protein Domains on the Emergence of Novel Viruses as SARS-CoV-2SARS-CoV-2와 같은 새로운 바이러스의 출현에 대한 프리온 유사 바이러스 단백질 도메인의 가능한 역할Article Published on 2022-08-012022-09-11 Journal: Journal of molecular evolution [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral antiviral agent Antiviral agents antiviral target central dogma coronavirus SARS-CoV-2 deviate domain effective emergence Evolution immune modulation in viral novel Novel viruses outlined persistent persistent infection PrDs Prion-like domains (PrDs) Protein Replication role SARS-CoV-2 viral evolution [DOI] 10.1007/s00239-022-10054-4 PMC 바로가기 [Article Type] Article
Progress on SARS-CoV-2 3CLpro Inhibitors: Inspiration from SARS-CoV 3CLpro Peptidomimetics and Small-Molecule Anti-Inflammatory CompoundsSARS-CoV-2 3CLpro 억제제에 대한 진행 상황: SARS-CoV 3CLpro 펩티드 모방체 및 소분자 항염 화합물에서 영감Review Published on 2022-04-082022-09-11 Journal: Drug design, development and therapy [Category] Coronavirus, COVID19(2023년), SARS, 치료제, [키워드] 3CLpro accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-inflammatory anti-inflammatory agents anti-inflammatory effect Anti-inflammatory effects Antiviral antiviral target caused Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Health inhibitor inhibitors inspiration life cycle pathophysiological peptidomimetics Progress protease protease inhibitors Protein proteinase SARS-CoV SARS-CoV-2 sequence homology Sequencing severe acute respiratory syndrome Coronavirus similarity small-molecule inhibitors. viral life cycle whole-genome sequencing [DOI] 10.2147/DDDT.S359009 PMC 바로가기 [Article Type] Review
In silico screening-based discovery of novel covalent inhibitors of the SARS-CoV-2 3CL proteaseSARS-CoV-2 3CL 프로테아제의 새로운 공유 억제제의 실리코 스크리닝 기반 발견Article Published on 2022-03-052022-09-11 Journal: European journal of medicinal chemistry [Category] SARS, 치료제, [키워드] 3CL 3CL pro acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral target approach carried catalytic complex Compound coronavirus coronavirus disease Coronavirus disease 2019 covalent binding covalent inhibitor COVID-19 crystal crystal structure database effective enzymatic activity evaluated example feasible identify inhibitor Interaction ligand binding pocket predicted protease provided residue SARS-CoV-2 SARS-CoV-2 3C-Like protease seeking severe acute respiratory syndrome Coronavirus small molecule the SARS-CoV-2 Treatment Virtual screening X-ray [DOI] 10.1016/j.ejmech.2022.114130 PMC 바로가기 [Article Type] Article
A multi-stage virtual screening of FDA-approved drugs reveals potential inhibitors of SARS-CoV-2 main proteaseFDA 승인 약물의 다단계 가상 스크리닝은 SARS-COV-2 주 프로테아제의 잠재적 억제제를 보여줍니다.Article Published on 2022-03-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis antiviral target applied approach approved binding mode caused Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment crystal structure crystal structures docking drug drug candidate drug candidates Drug repurposing extension FDA-approved drug filtration FIVE flavonoid followed by free energy functional protein H-bond health emergency identify inhibitor inhibitors inhibitors of SARS-CoV-2 M pro maturation MD simulations molecular molecular docking molecular dynamics pharmacophore Potential protease protease inhibitors protein-ligand interaction protocol reported repurposing respiratory responsible reveal RMSD SARS-CoV-2 SARS-CoV-2 main protease severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 trajectory Treatment Viral Virtual screening [DOI] 10.1080/07391102.2020.1837680 PMC 바로가기 [Article Type] Article
Efficacy and mechanisms of traditional Chinese medicine for COVID-19: a systematic reviewReview Published on 2022-02-282022-11-01 Journal: Chinese Medicine [Category] COVID-19, [키워드] addition Anti-inflammation Anti-inflammatory antiviral target Chinese Clinical symptoms cohort study component coronavirus disease Coronavirus disease 2019 COVID-19 Critical curtail database decrease demonstrated Efficacy evaluate Hospital stay Immunity IMPROVE involved Laboratory mechanism mechanisms Meta-analysis molecular docking mortality rate outbreak Patient proportion provided Randomized controlled trial RCT RCTs Regulation Research Retrospective study review searched Severe case suggested supplementary material systematic review target TCM the epidemic Traditional Chinese medicine was performed [DOI] 10.1186/s13020-022-00587-7 PMC 바로가기 [Article Type] Review