Highly efficacious and safe neutralizing DNA aptamer of SARS-CoV-2 as an emerging therapy for COVID-19 diseaseArticle Published on 2022-12-302023-07-11 Journal: Virology Journal [Category] COVID19(2023년), [키워드] ACE2 aptamer COVID-19 neutralization RBD Safety SARS-CoV-2 Spike S protein Toxicity virus. VLP [DOI] 10.1186/s12985-022-01943-7 PMC 바로가기
Enhanced Label-Free Nanoplasmonic Cytokine Detection in SARS-CoV-2 Induced Inflammation Using Rationally Designed Peptide AptamerArticle Published on 2022-11-022022-11-15 Journal: ACS applied materials & interfaces [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome Analysis Antibody-derived peptide aptamer (ADPA) applied aptamer Biomarker coronavirus COVID-19 patients cytokine detection Detection limit Disease progression disorders enhanced IL-6 immune pathway Immune status immunoassay immunoassays in vitro induced Inflammation inflammatory status information interleukin 6 (IL-6 Interluekin-6 (IL-6) Interpretation limit of detection localized surface plasmon resonance (LSPR) magnitude nanoplasmonic immunoassay pandemic pathogenic inflammation Patient peptide Predictive profile Prognosis provide quantification Rapid SARS-CoV-2 serum serum cytokine Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). [DOI] 10.1021/acsami.2c14748 PMC 바로가기
Highly sensitive aptasensor for the detection of SARS-CoV-2-RBD using aptamer-gated methylene blue@mesoporous silica film/laser engraved graphene electrodeArticle Published on 2022-11-012022-11-15 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 치료기술, [키워드] absence acute respiratory syndrome Analysis aptamer Aptamer gated-mesoporous silica film aptasensor C-reactive protein Coronavirus-2 Coverage detect Electrochemical measurement electrostatic encapsulation group high affinity indicated influenza A virus limit of detection phosphate porous probe Saliva SARS-CoV-2-RBD SARS-CoV-2-RBD. the receptor-binding domain was recorded [DOI] 10.1016/j.bios.2022.114556 PMC 바로가기
Sensitive Detection of SARS-CoV-2 Variants Using an Electrochemical Impedance Spectroscopy Based AptasensorArticle Published on 2022-10-282023-07-10 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), [키워드] aptamer aptasensor electrochemical impedance spectroscopy (EIS) SARS-CoV-2 spike glycoprotein virus. [DOI] 10.3390/ijms232113138 PMC 바로가기
An electrochemical aptasensor with N protein binding aptamer-complementary oligonucleotide as probe for ultra-sensitive detection of COVID-19N 단백질 결합 앱타머-상보성 올리고뉴클레오티드를 COVID-19의 초고감도 검출을 위한 프로브로 사용하는 전기화학적 앱타센서Article Published on 2022-10-012022-09-11 Journal: Biosensors & bioelectronics [Category] 치료기술, 치료제, [키워드] affected applied aptamer binding blood sample Blood samples changes in complementary Complementary DNA Concentration conformational COVID-19 COVID-19 epidemic COVID-19 in patients DNA double-stranded Early detection effective Electrochemical aptasensor gold hybridization Incubation linear relationship log logarithm N protein N protein detection probe R 2 Rapid Rapid COVID-19 diagnosis Regenerable aptamer sensor. reported sensor solution target the N protein throat swab throat swabs vaccination volunteers was measured [DOI] 10.1016/j.bios.2022.114436 PMC 바로가기 [Article Type] Article
Enzyme linked oligonucleotide assay for the sensitive detection of SARS-CoV-2 variantsArticle Published on 2022-09-292022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 진단, 치료기술, [키워드] antibody aptamer buffer condition conditions Delta delta variant detect detection Detection limit develop diagnostic effective elements ELONA human nasal fluid identify in vitro inactivated Modification predicted RBD reporter Research S glycoprotein S protein Sandwich SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variant Screening SEM sensitivity Spike protein spread of COVID-19 stability TCID variant viral particle virus virus. was obtained was used Wuhan [DOI] 10.3389/fcimb.2022.1017542 PMC 바로가기
Integration of Power-Free and Self-Contained Microfluidic Chip with Fiber Optic Particle Plasmon Resonance Aptasensor for Rapid Detection of SARS-CoV-2 Nucleocapsid ProteinArticle Published on 2022-09-232022-11-15 Journal: Biosensors [Category] SARS, 변종, 치료기술, 치료제, [키워드] antigen detection aptamer binding binding kinetics COVID-19 detect detection diagnostic fiber fiber optic biosensor global pandemic Gold nanoparticle infectious viruses integration leaking limit of detection localized surface plasmon resonance marker Microfluidic chip mutants N-protein novel coronavirus SARS-CoV-2 nucleocapsid nucleocapsid protein Optic Particle Plasmon POCT point-of-care Point-of-care testing. Rapid resonance risk robust SARS-CoV-2 single-stranded DNA ssDNA structural protein the SARS-CoV-2 the WHO virus [DOI] 10.3390/bios12100785 PMC 바로가기
SCORe: SARS-CoV-2 Omicron Variant RBD-Binding DNA Aptamer for Multiplexed Rapid Detection and Pseudovirus NeutralizationArticle Published on 2022-09-202022-11-15 Journal: Analytical Chemistry [Category] SARS, 변종, 진단, 치료기술, [키워드] antibody aptamer bind Cell Concentration coronavirus disease COVID-19 detection diagnostics dimerized DNA immune in viral Invasion lateral flow neutralization neutralize omicron pandemic Rapid RBD SARS-CoV-2 SARS-CoV-2 variant strain variant virus infection wild-type [DOI] 10.1021/acs.analchem.2c01993 PMC 바로가기
Label-free electrochemical aptasensor for rapid detection of SARS-CoV-2 spike glycoprotein based on the composite of Cu(OH) 2 nanorods arrays as a high-performance surface substrate고성능 표면 기판으로서 Cu(OH) 2 나노로드 어레이의 합성물을 기반으로 한 SARS-CoV-2 스파이크 당단백질의 신속한 검출을 위한 무표지 전기화학 앱타센서Article Published on 2022-08-012022-09-11 Journal: Bioelectrochemistry (Amsterdam, Netherlands) [Category] SARS, 치료기술, 치료제, [키워드] addition aptamer Aptamer-based sensors carbon Chain Reaction characterized Combination complexes copper Copper hydroxide nanorods COVID-19 cross-reactivity decrease Detection limit diffraction dynamic range Efficiency electrode electron microscopy electron transfer evaluated exhibited feasibility glycoprotein healthy individual high stability hydroxide immobilization lAbel Microscopy PCR polymerase chain polymerase chain reaction probe provided repeatability reproducibility Saliva SARS-CoV-2 SARS-CoV-2 spike glycoprotein Screen sensitivity sick spike spike glycoprotein spike glycoprotein. transport medium Viral transport medium VTM was used X-ray X-ray diffraction [DOI] 10.1016/j.bioelechem.2022.108106 PMC 바로가기 [Article Type] Article
CRISPR-Cas12a-mediated label-free electrochemical aptamer-based sensor for SARS-CoV-2 antigen detectionSARS-CoV-2 항원 검출을 위한 CRISPR-Cas12a 매개 무표지 전기화학 앱타머 기반 센서Article Published on 2022-08-012022-09-11 Journal: Bioelectrochemistry (Amsterdam, Netherlands) [Category] SARS, 치료기술, 치료법, [키워드] amplification Antigen aptamer Biomarkers cleavage competitive binding complex COVID-19 CRISPR CRISPR-Cas12a cross-reactivity diagnostic DNA electrochemical biosensor expand generate gold impedance in vitro nucleocapsid antigen Quantitative resulting Rolling circle amplification SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 nucleocapsid SARS-CoV-2. selective significant decrease significantly [DOI] 10.1016/j.bioelechem.2022.108105 PMC 바로가기 [Article Type] Article