The Role of Spike Protein Mutations in the Infectious Power of SARS-COV-2 Variants: A Molecular Interaction PerspectiveSARS-COV-2 변이체의 전염력에서 스파이크 단백질 돌연변이의 역할: 분자 상호작용 관점Article Published on 2022-04-052022-09-11 Journal: Chembiochem [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 receptor among others Analysis attachment B.1.1.28.1 B.1.351 bond Brazil correlated domain E484K mutation Effects Europe host cells hydrogen Hydrogen bond IMPROVE initial K417N molecular molecule molecules N501Y natural P.1 P.2 pair power quantum Quantum mechanics quantum theory RBD Receptor binding domain recognize reported residue residues role S477N Salt Bridge salt bridges SARS-CoV-2 virus significantly South Africa Specific spike Spike protein the spike protein theory United Kingdom variant virus wild type [DOI] 10.1002/cbic.202100393 PMC 바로가기 [Article Type] Article
Live attenuated virus vaccine protects against SARS-CoV-2 variants of concern B.1.1.7 (Alpha) and B.1.351 (Beta)Research Article Published on 2021-12-012022-10-28 Journal: Science Advances [Category] COVID-19, [키워드] B.1 B.1.1.28.1 B.1.1.7 B.1.351 B.1.617.2 Beta caused Complete COVID-19 pandemic cross-neutralizing antibody response Delta description disease Efficacy elicited evade Gamma hamster Infection intranasal offered PROTECT Protective provide SARS-CoV-2 SARS-CoV-2 variant susceptible the SARS-CoV-2 genome vaccination Vaccine vaccine candidate variants of concern virus VoC [DOI] 10.1126/sciadv.abk0172 PMC 바로가기 [Article Type] Research Article
Host Response to SARS-CoV2 and Emerging Variants in Pre-Existing Liver and Gastrointestinal Diseases기존 간 및 위장 질환의 SARS-CoV2 및 새로운 변이체에 대한 숙주 반응Review Published on 2021-10-252022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, 치료기술, [키워드] accumulation ACE2 receptor Alpha Alter Altered B.1.1.28.1 B.1.1.7 B.1.351 Beta binding Brazil changes in characteristic CLARITY cleavage condition coronavirus COVID-19 cytokine Cytokine storm Definitive determinant diabetes disease Diseases disorder disorders distribution drastic E484K emerging variants expression feature finding First wave Gastrointestinal gastrointestinal disease Generation GI Tract Host Host immune response host protease host protease TMPRSS2 host response hypertension Immune escape Immune status immunocompromised condition immunomodulation implicated incidence India indicate Infection Inflammation L452R lack less liver liver failure Liver injury manifestation Manifestations mechanism Mild Mortality Mutation N501Y novel Novel coronavirus obesity occur organs outcome outcomes P681R pandemic Patient predominant Protein binding radiologic receptor Receptor binding Replication reported required response risk factor RNA SARS-CoV2 selection pressure several variant several variants severe COVID-19 shown South Africa Spike protein Stool Symptoms systemic inflammation the disease the spike protein tissue expression TMPRSS2 Transmissibility Transmission underlying disease underlying diseases variant variants variants of concern Viral viral entry viral genome Viral proteins Viremia virulence virus virus clearance VoC [DOI] 10.3389/fcimb.2021.753249 PMC 바로가기 [Article Type] Review
[COVID-19: epidemiology and mutations : An update][COVID-19: 역학 및 돌연변이 : 업데이트]Review Published on 2021-10-012022-09-11 Journal: Radiologe [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Alpha Alpha variant antibody antibody treatment approach AstraZeneca B.1.1.28.1 B.1.1.7 B.1.351 B.1.617 bamlanivimab Beta variant Brazil caused circulating coronavirus Course courses decrease delta variant described disease severity dominant Effectiveness English ENhance Epidemiology fatal disease Germany herd immunity Immunity India Infection infectiousness Kingdom less life-threatening Mild moderate disease monoclonal antibodies monoclonal antibody mortality risk Mutation mutations neutralization ability offer outcome P.1 pandemic protective effect rule SARS-CoV-2 SARS-CoV‑2 severe acute respiratory syndrome Coronavirus South Africa Spread symptomatic disease the disease the vaccine vaccination vaccination rate Vaccinations Vaccine variant variants virus strain virus variants wild type [DOI] 10.1007/s00117-021-00909-0 PMC 바로가기 [Article Type] Review
Comparing infectivity and virulence of emerging SARS-CoV-2 variants in Syrian hamsters시리아 햄스터의 신종 SARS-CoV-2 변이체의 감염력 및 독성 비교Comparative Study Published on 2021-05-252022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] African Analysis antibodies Antiviral B.1.1.28.1 B.1.1.7 B.1.351 B.1.351 variant B.1.351 variants Candidates clinical evidence COVID-19 cytokine Cytokines disease dominant Efficacy emergence Epidemics expression profile expression profiles female finding funding Genes golden hamsters hamster Hamster model hamsters histological Infection Lower respiratory tract New outcome Patient pro-inflammatory cytokine Proinflammatory cytokine proinflammatory cytokines quantified relative infectivity replacing respiratory SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant selected Small molecules South strain Strains Syrian golden hamster tomography transmitted United Kingdom Vaccine-induced immunity variants variants of concern (VOC) virulence virulent [DOI] 10.1016/j.ebiom.2021.103403 PMC 바로가기 [Article Type] Comparative Study
Mild Symptomatic SARS-CoV-2 P.1 (B.1.1.28) Infection in a Fully Vaccinated 83-Year-Old ManCase Report Published on 2021-05-172022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] A.23.1 acute respiratory syndrome antibody B.1.1.28 B.1.1.28.1 B.1.351 B.1.525 BNT162b2 mRNA Brazil Brazilian variant coronavirus coronavirus disease COVID-19 COVID-19 vaccine dose Efficacy Immunity implication infections Lineage B.1.1.7 Man Nigeria P.1 P.1 variant reported SARS-CoV-2 South Africa Spread the SARS-CoV-2 therapeutic Uganda Vaccine variants of concern VoC VOCs [DOI] 10.3390/pathogens10050614 PMC 바로가기 [Article Type] Case Report
Mutation in a SARS-CoV-2 Haplotype from Sub-Antarctic Chile Reveals New Insights into the Spike’s DynamicsArticle Published on 2021-05-112022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] 501Y.V1 501Y.V2 accompanied B.1.1.28.1 B.1.1.7 B.1.351 Comparative continuous surveillance COVID19 D614G domain Dynamics Haplotype higher infectivity highest incidence rate indicated insight Lineage lineages molecular molecular analysis molecular mechanism mutant Mutation New nine Occurrence P.1 Receptor binding domain Region replaced resulting SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 variants SARS-CoV2 significant increase Spike protein strain synergistic variant Variation virulence [DOI] 10.3390/v13050883 PMC 바로가기 [Article Type] Article
New Brazilian variant of the SARS-CoV-2 (P1/Gamma) of COVID-19 in Alagoas stateAlagoas 주에서 COVID-19의 SARS-CoV-2(P1/Gamma)의 새로운 브라질 변종Case Reports Published on 2021-05-012022-09-11 Journal: The Brazilian journal of infectious diseases : an [Category] SARS, 변종, [키워드] B.1.1.28.1 Brazil community transmission confirmed case coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 deaths described Economy had no health authorities Health authority Mild New New coronavirus occurred pandemic SARS-CoV-2 SARS-CoV-2 variant Spread state Symptom the patient the SARS-CoV-2 threat Threats Travel variant variant of SARS-CoV-2 [DOI] 10.1016/j.bjid.2021.101588 PMC 바로가기 [Article Type] Case Reports
Structure-Function Analyses of New SARS-CoV-2 Variants B.1.1.7, B.1.351 and B.1.1.28.1: Clinical, Diagnostic, Therapeutic and Public Health Implications새로운 SARS-CoV-2 변이체 B.1.1.7, B.1.351 및 B.1.1.28.1의 구조 기능 분석: 임상, 진단, 치료 및 공중 보건에 미치는 영향Article Published on 2021-03-092022-09-01 Journal: Viruses [Category] SARS, 변종, 진단, 치료법, [키워드] 501Y.V1 501Y.V2 accumulated acute respiratory syndrome Anti-viral antibodies Antibody binding antibody resistance B.1.1.28.1 B.1.1.7 B.1.351 binding Brazil candidate Candidates circulation Clade G clinical COVID-19 COVID-19 vaccines current D614G variant described diagnostic diagnostic sensitivity diagnostic test diagnostic tests Effect epitope followed by functional furin cleavage site higher affinity host receptor Host receptors host tropism Immune escape impacts implication lead lineages Missense modulation molecular molecular dynamics multiple mutation multiple mutations Mutation N501Y N501Y mutation New nucleocapsid ORF8 P.1 Post-vaccine predicted Proteins Public public health public health strategies regions Reinfection resource respiratory roll S protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity Severe acute respiratory syndrome South Africa Spike protein the S protein therapeutic United Kingdom vaccine delivery variant while [DOI] 10.3390/v13030439 PMC 바로가기 [Article Type] Article