bacterial metabolite – Communicable Diseases Research

Ferulic acid and berberine, via Sirt1 and AMPK, may act as cell cleansing promoters of healthy longevity

Sirt1과 AMPK를 통한 페룰산과 베르베린은 건강한 장수의 세포 정화 촉진제로 작용할 수 있습니다

Review

Published on 2022-03-012022-09-11
Journal: Open Heart [Category] SARS, 유전자 메커니즘, 치료기술,

[키워드] activating Activation AMPK amplify amplifying anthocyanin Anti-inflammatory effects antioxidant Apoptosis appear autophagy bacterial metabolite benefit berberine biogenesis boost carotid carotid artery carotid artery diseases Cell cell survival cellular cellular senescence Chinese clinically complementary Concentration conjunction coronary angiography deficit detect DNA DNA repair echocardiography Effect endothelial ENhance enzyme expression ferulic acid function functions Health health benefits healthy independent Inflammation inhibiting mechanism mediator mitochondrial molecular basis mRNA NAD+ NF-kB nicotinamide Nrf2 nutraceutical Phase 2 promote promoter Protective protective effect protein level protein levels SARS-CoV-2 spike protein SIRT1 Spike protein survival synergistic the SARS-CoV-2 tissues Toxicity transcription factor turn
[DOI] 10.1136/openhrt-2021-001801 PMC 바로가기 [Article Type] Review

Safety and target engagement of an oral small-molecule sequestrant in adolescents with autism spectrum disorder: an open-label phase 1b/2a trial

Research

Published on 2022-02-142022-10-05
Journal: Nature Medicine [Category] 바이오마커, 임상, 진단,

Metabolites with SARS-CoV-2 Inhibitory Activity Identified from Human Microbiome Commensals

Research Article

Published on 2021-12-012022-10-30
Journal: mSphere [Category] COVID-19, SARS,

[키워드] activity Anti-SARS-CoV-2 Activity Antiviral antiviral activities antiviral activity antiviral property antivirals Bacteria bacterial metabolite Bioactivity Biochemistry biological activities clinically commensal complement Compound COVID-19 COVID-19 pandemic Culture drug Evidence examined fraction functional host receptor Human Identified identify in vitro inhibit SARS-CoV-2 inhibiting inhibitory concentration Isolation ligands metabolite Microbiome Molecular biology natural antiviral phylogenetically platform prevalence of COVID-19 Prevent produced receptor reported SARS-CoV-2 SARS-COV-2 infection screened similarity small molecule Therapies Treatment variant viral infections Virology
[DOI] 10.1128/mSphere.00711-21 PMC 바로가기 [Article Type] Research Article

Commensal bacterial metabolites may strengthen the effect of anti-IL6 treatment for COVID-19

공생 박테리아 대사 산물은 COVID-19에 대한 항 IL6 치료의 효과를 강화할 수 있습니다

Comment

Published on 2021-11-012022-09-12
Journal: Clinical immunology (Orlando, Fla.) [Category] MERS, SARS, 진단,

[키워드] Abstract anti-IL6 bacterial metabolite Butyrate commensal COVID-19 regulatory T cells Tocilizumab treatment for COVID-19
[DOI] 10.1016/j.clim.2021.108870 PMC 바로가기 [Article Type] Comment

Association between the nasopharyngeal microbiome and metabolome in patients with COVID-19

Research article

Published on 2021-09-012022-10-05
Journal: Synthetic and Systems Biotechnology [Category] 바이오마커, 유전자 메커니즘,

Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19

Review

Published on 2021-06-292022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

MAIT cell activation and dynamics associated with COVID-19 disease severity

Report

Published on 2020-09-252022-10-28
Journal: Science Immunology [Category] COVID-19, Fulltext, SARS,

[키워드] Activation Active disease acute COVID-19 Affect airways Analysis antiviral responses bacterial metabolite Blood CD69 Cell cell activation cells characterized circulating circulation Clinical outcome contribute convalescent COVID-19 patient convalescent phase coronavirus disease COVID-19 COVID-19 patient CXCR3 disease disease severity elicit excessive inflammation feature host response IL-17A immune response Immunopathogenesis immunotype indicated Infection Innate lymphoid cells investigated lower airways Lymphocyte subsets moderate normalized Parrot Patient Pneumonia proinflammatory Protective recognize recruitment resolved respiratory tract Responder SARS-CoV-2 SARS-COV-2 infection severe disease severity T cell T cells tissue transcriptomic viral infection with COVID-19
[DOI] 10.1126/sciimmunol.abe1670 PMC 바로가기 [Article Type] Report

Immediate activation of chemosensory neuron gene expression by bacterial metabolites is selectively induced by distinct cyclic GMP-dependent pathways in Caenorhabditis elegans

박테리아 대사 산물에 의한 화학 감각 뉴런 유전자 발현의 즉각적인 활성화는 Caenorhabditis elegans에서 별개의 순환 GMP 의존 경로에 의해 선택적으로 유도됩니다

Research Article

Published on 2020-08-102022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activate Activation addition animals Author avoidance bacterial metabolite Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans calcium canonical cGMP chemosensory cyclic GMP dependent on detect dissect dynamic elegan elegans engage expression external environment gene encoding Gene Expression highlighting Immediate induce intracellular signaling lead Ligand mechanism metabolite metabolites microbial modulate nervous system neuroendocrine Neuron neuronal neurons P . aeruginosa pair pathogen pathogenic pathogenic bacteria pathogenic bacterium pathway produced Protective Protein protein kinase Pseudomonas aeruginosa required response selective sensation sensory neuron sensory neurons Signal transduction Signaling signaling pathway subunit TGF-β Transcription transcriptional transcriptional response turn
[DOI] 10.1371/journal.pgen.1008505 PMC 바로가기 [Article Type] Research Article