Bacterial sepsis – Communicable Diseases Research

Microvascular and proteomic signatures overlap in COVID-19 and bacterial sepsis: the MICROCODE study

Article

Published on 2022-11-012022-11-15
Journal: Angiogenesis [Category] 바이오마커, 유전자 메커니즘,

Temporal dynamics of oropharyngeal microbiome among SARS-CoV-2 patients reveals continued dysbiosis even after Viral Clearance

Research

Published on 2022-08-242022-10-05
Journal: NPJ Biofilms and Microbiomes [Category] SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome administration Antibiotics Azithromycin Bacteria Bacterial infection Bacterial sepsis bacterial species Chryseobacterium clinical Clinical diagnosis clinically commensal bacteria compensated Complication complications Coronavirus-2 elevated feature Firmicute global public health healthy controls Human include indicate individuals Infection Influenza Klebsiella lung Lung infection microbial Microbiome morbidity and mortality observation oral organism Oropharyngeal oropharynx outbreak pandemic persist Pneumonia present proportion Proteobacteria reduced respiratory virus response reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 positive individual secondary bacterial infection Sepsis shown stability Temporal the patient viral clearance
[DOI] 10.1038/s41522-022-00330-y [Article Type] Research

Platelet activation and partial desensitization are associated with viral xenophagy in patients with severe COVID-19

혈소판 활성화 및 부분 탈감작은 중증 COVID-19 환자의 바이러스 이종과 관련이 있습니다

Article

Published on 2022-07-122022-09-11
Journal: Blood advances [Category] COVID19(2023년), SARS, 치료법,

[키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aggregation Alter assays autophagy Bacterial sepsis changes in Combination Complication coronavirus Critically ill critically ill patients Cytokines decrease develop exhibited flow cytometry fraction Gene Expression GPVI healthy healthy donor healthy donors immunofluorescence indicated infected patient infected patients intensive care intensive care unit interactions intracellular vesicle investigated labeling leukocyte Localization lung marker mass spectrometry Microscopy Nucleocapsid proteins parameter Patient patients with COVID-19 plasma Platelet platelet activation platelet aggregation platelet-rich thrombi Platelets Proinflammatory cytokine proinflammatory cytokines prospective cohort Protein reduction SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 particles secretion selective Sepsis severe acute respiratory syndrome Coronavirus severe COVID-19 shown spike Stimulation Structure Tandem mass spectrometry These data thrombi thrombocytopenia transmission electron microscopy Xenophagy
[DOI] 10.1182/bloodadvances.2022007143 PMC 바로가기 [Article Type] Article

Heparanase Is a Putative Mediator of Endothelial Glycocalyx Damage in COVID-19 – A Proof-of-Concept Study

헤파라나제는 COVID-19에서 내피 글리코칼릭스 손상의 추정 매개체입니다 - 개념 증명 연구

Article

Published on 2022-06-102022-09-12
Journal: Frontiers in Immunology [Category] MERS, 진단,

Trends in bacterial sepsis incidence and mortality in France between 2015 and 2019 based on National Health Data System (Système National des données de Santé (SNDS)): a retrospective observational study

Observational Study

Published on 2022-05-242022-10-05
Journal: BMJ Open [Category] 임상,

Fibronectin as a Marker of Disease Severity in Critically Ill COVID-19 Patients

중환자 COVID-19 환자의 질병 중증도 지표로서의 피브로넥틴

Article

Published on 2022-05-062022-09-11
Journal: Cells [Category] Coronavirus, COVID19(2023년), MERS, SARS, 바이오마커, 치료기술,

[키워드] Alter APACHE II Bacterial Bacterial sepsis Biomarker Biomarkers can be used cellular clinical setting clinical settings correlated COVID-19 COVID-19 patient COVID-19 patients COVID-19 sample COVID-19 samples Critically ill Critically ill patient critically ill patients disease severity ELISA etiology expression of gene Extracellular matrix Fibronectin form help Ill immune response immunoblotting Infection Intensive intensive care intensive care unit knowledge MONITOR Mortality mortality prediction no significant difference no significant differences Non-survivors outcomes Patient plasma predict Proteins proteolytic Research SARS-CoV-2 virus Sepsis significantly higher SOFA scores treated Treatment Treatment outcome Viral was related were measured
[DOI] 10.3390/cells11091566 PMC 바로가기 [Article Type] Article

Recombinant human interleukin-7 reverses T cell exhaustion ex vivo in critically ill COVID-19 patients

Research

Published on 2022-03-052022-10-28
Journal: Annals of Intensive Care [Category] COVID-19,

[키워드] administration Admission alteration alterations approaches Bacterial sepsis Blood Cell cell proliferation characteristic clinical setting collected COVID-19 COVID-19 patient COVID-19 patients Critically ill Critically ill patient CTLA-4 described evaluated Ex vivo Exhaustion expression feature flow cytometry hallmark Hospitalized ICU ICU admission ICU patient IFN-γ immune immunostimulation inhibited intensive care interleukin-7 lymphopenic marker mononuclear cell over-expression pathophysiology Pathways Patient PD-L1 peripheral proliferation recombinant Result reversed SARS-CoV-2 Sepsis severe coronavirus disease severe COVID-19 severe COVID-19 patient significantly supplementary material T cell T cell activation T cell proliferation T lymphocyte T lymphocyte response T lymphocytes therapeutic therapeutic strategy therapy transcriptomic profile treat
[DOI] 10.1186/s13613-022-00982-1 PMC 바로가기 [Article Type] Research

Endogenous Carboxyhemoglobin Level Variation in COVID-19 and Bacterial Sepsis: A Novel Approach?

Article

Published on 2022-01-272022-10-29
Journal: Microorganisms [Category] COVID-19,

COVID-19 and Sepsis

Article

Published on 2021-12-172022-10-29
Journal: Turkish Journal of Medical Sciences [Category] COVID-19, SARS,

[키워드] acute phase reactant acute respiratory distress addition affecting alterations ARDS assist association Autopsy Bacterial sepsis Blood cause caused Cell changes chemokine Clinical deterioration coagulation tests component consolidation contributing to Course COVID-19 COVID-19 pandemic COVID-19 pathogenesis COVID-19 patient COVID-19 sepsis CRP Cytokine storm D-dimer demonstrated Diffuse alveolar damage direct viral infection dominant dysregulated immune response endothelial injury explained Faeces feature ferritin Gallbladder hematological hemorrhage histopathological HLH hospitalized patient Hyperactivation hypercoagulability hypercoagulable hyperinflammation immune immune response IMPROVE indicated infiltration inflammatory cell intrinsic Laboratory laboratory parameter limit liver liver function tests lung tissue Lungs macrophages manifestation modulate multiorgan failure multiple organ organ systems organs outcome overlapping pandemic Pathogenesis pathogenesis of COVID-19 Pathogens Result SARS-CoV-2 Sepsis serum cytokine Severe case severe COVID-19 severe COVID-19 disease Severe COVID-19 Infection severe COVID-19 patients similarity syndrome systemic inflammation tissue Treatment unique Urine Vascular viral disease viral particle virus while
[DOI] 10.3906/sag-2108-239 PMC 바로가기 [Article Type] Article

Overlapping but Disparate Inflammatory and Immunosuppressive Responses to SARS-CoV-2 and Bacterial Sepsis: An Immunological Time Course Analysis

Observational Study

Published on 2021-12-092022-10-04
Journal: Frontiers in Immunology [Category] SARS, 임상,

[키워드] addition Admission Analysis Bacterial sepsis Cell cellular circulating Clinical outcome clinical outcomes Cohort Course COVID patient Critically ill patient dyscrasia elevated ELISPOT enzyme-linked immunospot assay etiology Ex vivo exhibited expression functional healthy control HLA-DR hospitalized patient IFN-gamma immune immune response Immune suppression immunological Immunosuppression incidence Infection Inflammation Inflammatory marker initial less leukocyte MDSC mononuclear cell organ dysfunction patients physiologic derangement plasma biomarker reduced response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient secondary bacterial infection Secondary infection secondary infections severe SARS-CoV-2 significantly higher subjects suffered suppressed time TNF-alpha
[DOI] 10.3389/fimmu.2021.792448 PMC 바로가기 [Article Type] Observational Study