Molecular Insights into the Assembly and Functional Diversification of Typhoid Toxin장티푸스 독소의 조립 및 기능적 다양화에 대한 분자적 통찰력Research Article Published on 2022-01-112024-07-29 Journal: mBio [Category] 살모넬라증, [키워드] AB5 toxins Bacterial pathogenesis bacterial toxins glycobiology Salmonella Typhi typhoid fever [DOI] 10.1128/mbio.01916-21 PMC 바로가기 [Article Type] Research Article
Foodborne Toxigenic Agents Investigated in Central Italy: An Overview of a Three-Year Experience (2018–2020)Article Published on 2022-01-052022-10-28 Journal: Toxins [Category] Coronavirus, SARS, [키워드] agent analysed bacterial pathogen bacterial toxins clinical diagnose clinical sample collected competent conducted Contamination COVID-19 COVID-19 pandemic develop diagnosed Diagnosis disease Epidemiological investigation experience food foodborne diseases foodborne pathogens Health identify incidence indicate involved Lazio Microbiology outbreak pathogen positive public health source of infection submitted Toxigenic toxin unit [DOI] 10.3390/toxins14010040 PMC 바로가기 [Article Type] Article
Cholesterol stimulates the lytic activity of Adenylate Cyclase Toxin on lipid membranes by promoting toxin oligomerization and formation of pores with a greater effective sizearticle Published on 2021-12-312024-09-01 Journal: The FEBS Journal [Category] 백일해, [키워드] adenylate cyclase bacterial toxins lipid-protein interactions pore-forming proteins [Article Type] article
Adjuvants: friends in vaccine formulations against infectious diseasesReview Published on 2021-07-212024-09-04 Journal: Human vaccines & immunotherapeutics [Category] 대상포진, [키워드] bacterial toxins CpGODN immunostimulants MPL Poly IC type I IFNs [DOI] 10.1080/21645515.2021.1934354 PMC 바로가기 [Article Type] Review
Spatiotemporal persistence of multiple, diverse clades and toxins of Corynebacterium diphtheriaeArticle Published on 2021-03-082022-10-04 Journal: Nature Communications [Category] 변종, [키워드] analysed Antibiotic resistance Bacterial evolution Bacterial genomics bacterial toxins breadth caused clade Cluster core gene Corynebacterium diphtheriae country determine Diphtheria generate Genome genomic variation greater increase in isolate isolates Isolation medium Mutation Numerous Pathogens persistence Phylogeny Region resistance gene resistance genes Respiratory disease the disease toxin Vaccine variants Variation [DOI] 10.1038/s41467-021-21870-5 PMC 바로가기 [Article Type] Article
Proteolytic cleavage of HLA class II by human neutrophil elastase in pneumococcal pneumonia인간 호중구 엘라스타제에 의한 폐렴구균 폐렴에서 HLA 클래스 II의 단백질 분해 절단Article Published on 2021-01-282024-07-30 Journal: Burma Med J [Category] 폐렴구균 감염증, [키워드] Bacterial immune evasion Bacterial infection bacterial toxins Infectious diseases Microbiology [DOI] 10.1038/s41598-021-82212-5 PMC 바로가기 [Article Type] Article
Human genome diversity data reveal that L564P is the predominant TPC2 variant and a prerequisite for the blond hair associated M484L gain-of-function effect인간 게놈 다양성 데이터는 L564P가 우세한 TPC2 변이체이며 M484L 기능 획득 효과와 관련된 금발 머리의 전제 조건임을 보여줍니다Research Article Published on 2021-01-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence addition affected Analysis analyzed association Bacterial infections bacterial toxin bacterial toxins Cancer cancer cell Cancer cells cation channel changes in characterized cholera toxin cholesterol data set database Degradation described diabete diabetes disease Diseases distribution drug target Ebola Ebola virus Effect example functional gain-of-function Genome Genome-wide association studies Genome-wide association study geographical distribution glucagon hair color Human human disease Human genome human population human populations implicated Infectious disease Infectious diseases investigated isoform likelihood melanin Meta-analysis metabolic disease mice nucleotide obesity overlapping Parkinson’s disease pathophysiological pharmacological physiological pigmentation defect pigmentation defects polymorphism Polymorphisms populations predominant Protein provide reduced resulting secretion Single nucleotide polymorphism single nucleotide polymorphisms systematic analysis traits Treatment variant Variation variations virus viruses was performed were assessed [DOI] 10.1371/journal.pgen.1009236 PMC 바로가기 [Article Type] Research Article
Generation and Characterization of Typhoid Toxin-Neutralizing Human Monoclonal Antibodies장티푸스 독소 중화 인간 단클론 항체의 생성 및 특성화Article Published on 2020-09-182024-08-21 Journal: Infection and Immunity [Category] 살모넬라증, [키워드] Bacterial pathogenesis bacterial toxins Infectious diseases monoclonal antibodies Salmonella paratyphi Salmonella Typhi Therapeutics typhoid fever
The bright and dark sides of protein conformational switches and the unifying forces of infections단백질 구조 전환의 밝은 면과 어두운 면과 감염의 통합력Review Published on 2020-07-152022-09-10 Journal: Communications Biology [Category] SARS, 신약개발, 치료제, [키워드] Alter Bacterial bacterial toxins cellular entry Combination conformation conformational derived proteins domain functions glycoprotein Host identify Infection infections membrane molecular pathogen Pathogenesis Pathogens Perspective Protein Protein sequence analyses Proteins sequence sequences similarity spike glycoprotein Spike protein structural biology switching the Spike toxins virus viruses [DOI] 10.1038/s42003-020-1115-x PMC 바로가기 [Article Type] Review
Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin폐렴구균 혈청형 1의 병원성이 증가하는 것은 빠른 자가 용해와 폐렴용해소의 방출에 의해 촉진된다.Article Published on 2020-04-202024-07-31 Journal: Nature Communications [Category] 폐렴구균 감염증, [키워드] Bacterial pathogenesis bacterial toxins Bacteriology Infection [DOI] 10.1038/s41467-020-15751-6 PMC 바로가기 [Article Type] Article