Inhibitory Efficacy of Main Components of Scutellaria baicalensis on the Interaction between Spike Protein of SARS-CoV-2 and Human Angiotensin-Converting Enzyme IIArticle Published on 2024-03-022024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] Angiotensin-converting enzyme 2 (ACE2) baicalein baicalin SARS-CoV-2 Scutellaria baicalensis Spike protein Traditional Chinese medicine [DOI] 10.3390/ijms25052935 PMC 바로가기 [Article Type] Article
An integrated metabolomic and proteomic approach for the identification of covalent inhibitors of the main protease (Mpro) of SARS-COV-2 from crude natural extractsArticle Published on 2023-01-152022-11-15 Journal: Talanta [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Analysis applied approach baicalein binding carried catalytic characteristic Chinese complementary complex Compound Covalent binder Cys145 database drug target electrophilic Final functional HIS163 HIS164 His41 independent inhibitor inhibitors Ion knowledge M pro M(pro) mass mass spectrometry maturation metabolomic metabolomics Michael molecular dynamics MPro nucleophilic peptide platform polyprotein protease protein-ligand Proteins proteomic proteomics residue SARS-CoV-2 Scutellaria baicalensis tested the SARS-CoV-2 [DOI] 10.1016/j.talanta.2022.123824 PMC 바로가기
Crystal structure of SARS-CoV 3C-like protease with baicaleinArticle Published on 2022-06-302023-07-09 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), [키워드] 3C-like protease baicalein SARS-CoV [DOI] 10.1016/j.bbrc.2022.04.086 PMC 바로가기
Both Baicalein and Gallocatechin Gallate Effectively Inhibit SARS-CoV-2 Replication by Targeting M pro and Sepsis in Mice바이칼레인과 갈로카테킨 갈레이트는 모두 쥐의 M pro와 패혈증을 표적으로 하여 SARS-CoV-2 복제를 효과적으로 억제합니다Article Published on 2022-06-012022-09-11 Journal: Inflammation [Category] COVID19(2023년), SARS, 치료제, [키워드] antiviral drug antiviral drugs baicalein Case fatality rate catalytic site caused Compound coronavirus COVID-19 COVID-19 pandemic COVID-19 patient Cys145 cytokine Cytokine storm Cytokine storms develop docking result effective evaluated Fatality rate flavonoid flavonoids gallate hydrogen Hydrogen bond IL-10 IL-1α IL-4 increase Inflammatory inhibitory activity limit M pro Mild molecular docking mouse model Mouse models MPro Mpro protease murine No effective drug Novel coronavirus protease reduced Research SARS-CoV-2 Sepsis Severe patient severe patients significantly survival rate Symptom syndrome targeting the SARS-CoV-2 TNF-α Treatment weight Z-score Z-scores [DOI] 10.1007/s10753-021-01602-z PMC 바로가기 [Article Type] Article
Efficient discovery of potential inhibitors for SARS-CoV-2 3C-like protease from herbal extracts using a native MS-based affinity-selection method천연 MS 기반 친화성 선택 방법을 사용하여 허브 추출물에서 SARS-CoV-2 3C 유사 프로테아제에 대한 잠재적 억제제의 효율적인 발견Article Published on 2022-02-052022-09-11 Journal: Journal of pharmaceutical and biomedical analysis [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CL 3CL Protease 3CLpro acquisition acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 applied baicalein binding affinity characterized China Cirsium complexes Compound compounds conducted Coronaviral coronavirus COVID-19 COVID-19 therapy Data acquisition Data processing Effectiveness efficient effort flavonoids Forsythia fraction Fractions Glycyrrhiza uralensis identify incubated Infection inhibitor investigated life cycle Ligand Lonicera japonica Native Native MS natural natural product outcomes protease protein-ligand resources SARS-CoV-2 scutellarein Scutellaria baicalensis severe acute respiratory syndrome Coronavirus small molecule Standard TCM therapy Traditional Chinese medicine traditional Chinese medicines Treatment UHPLC Virus life cycle were used [DOI] 10.1016/j.jpba.2021.114538 PMC 바로가기 [Article Type] Article
Identification of potential edible mushroom as SARS-CoV-2 main protease inhibitor using rational drug designing approachArticle Published on 2022-01-272022-10-04 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] 6LU7 approach approved baicalein binding free energy Care Compound Computational biology and bioinformatics COVID-19 docking Drug discovery FDA Health highly pathogenic Human identification indicated inhibitor inhibitors inhibitory Keeping M pro medication MM/PBSA molecular multiplex Polyozellus protease Protein researcher respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease therapeutic threat Treatment Vaccine Virtual drug screening Virtual screening was performed [DOI] 10.1038/s41598-022-05349-x PMC 바로가기 [Article Type] Article
The Potential Bioactive Components of Nine TCM Prescriptions Against COVID-19 in Lung Cancer Were Explored Based on Network Pharmacology and Molecular DockingMedicine Published on 2022-01-202022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE2 ACE2 binding ADRB2 Against Analysis anti-SARS-CoV-2 baicalein China Chinese Chinese medicine component Compound COVID-19 cross database differentially expressed gene enrichment analysis expression FOS Frequency Gene ontology GeneCards highest HMOX1 Hydrogen bond hydrophobic ICAM1 identify IL6 immune immune function immune-related gene immunization ingredient Interaction JUN KEGG Kyoto lung adenocarcinoma molecular docking molecular target National Health Commission network network pharmacology NFKBIA NHC nine objective Occurrence overlapped overlapping performed Pharmacology platform positively correlated Potential potential mechanism prescription Result screened selected Stat1 target target gene TCM TCMSP therapeutic target UniProt viral transcription was used were used with COVID-19 [DOI] 10.3389/fmed.2021.813119 PMC 바로가기 [Article Type] Medicine
Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitroScutellaria baicalensis 추출물 및 Baicalein은 SARS-COV-2 및 그의 3C- 유사 프로테아제의 복제를 시험관 내에서 억제합니다.Article Published on 2021-12-012022-08-31 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] SARS, 치료제, [키워드] 3C-like protease 3CL pro analogue Anti-SARS-CoV-2 Activity baicalein baicalein. broad spectrum Compound Concentration COVID-19 drug Drug discovery drugs Ethanol global pandemic in vitro inhibit inhibit SARS-CoV-2 protease Replication replication of SARS-CoV-2 SARS-CoV SARS-CoV-2 Scutellaria baicalensis Vero Cell Vero cells Viral viral entry virus while [DOI] 10.1080/14756366.2021.1873977 PMC 바로가기 [Article Type] Article
Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic ReviewSARS-CoV-2 표적에 대한 천연 플라보노이드의 유망한 항바이러스 활성: 체계적인 검토Review Published on 2021-10-142022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 치료법, 치료제, [키워드] 3CLpro activities activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration Analysis baicalein baicalin caused Clinical studies clinical study Combination coronavirus COVID-19 pandemic derivatives drug Effect EGCG flavonoid flavonoids focus Immunity in silico in vitro In vitro studies in vitro study in vivo investigated lack less MERS MERS-CoV Mutation myricetin natural nucleocapsid protease public health quercetin respiratory review SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus silico studies strain synthetic drugs tannic acid target targets the disease therapeutic intervention therapeutic potential Vaccines viruses [DOI] 10.3390/ijms222011069 PMC 바로가기 [Article Type] Review
Simple and Rapid Method for Wogonin Preparation and Its BiotransformationArticle Published on 2021-08-202022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, SARS, [키워드] Radix Scutellariae Scutellaria baicalensis activities anticancer baicalein baikal skullcap Biotransformation catalyzed Chinese complement COVID-19 determine effective exhibit glucoside glycosylation ingredient Isolation knowledge lack management Medicine metabolism microorganism microorganisms Phase I preparation provide Rapid Scutellaria baicalensis simple tested therapeutic therapeutic use was used were used wogonin [DOI] 10.3390/ijms22168973 PMC 바로가기 [Article Type] Article