Systematic Network and Meta-analysis on the Antiviral Mechanisms of Probiotics: A Preventive and Treatment Strategy to Mitigate SARS-CoV-2 Infection프로바이오틱스의 항바이러스 메커니즘에 대한 체계적인 네트워크 및 메타 분석: SARS-CoV-2 감염을 완화하기 위한 예방 및 치료 전략Comment Published on 2021-08-012022-09-11 Journal: Probiotics and antimicrobial proteins [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Activation affecting Analysis association biological network Biological network analysis boosting immunity candidate gene Clinical outcome common cold Comorbidities concerning country COVID-19 deaths domain functional Glucose Gut gut microbiome gut microbiota gut-lung axis Immune cell immune system immunomodulatory Immunosuppressed implementation IMPROVE individuals with COVID-19 infect infected case infected cases lung cells Lung infection lung tissue Meta-analysis metabolic pathway Microbiome Migration modulating molecular target network NLRP3 offer pandemic Pathway enrichment analysis Pathways Pneumonia Probiotics Prognosis rationale Respiratory illness resulting SARS-CoV-2 severity shown specific treatment Strategy systemic immune response the disease therapeutic effect therapeutic effects therapeutic strategy treating COVID-19 Treatment viral infection virus virus entry with COVID-19 [DOI] 10.1007/s12602-021-09748-w PMC 바로가기 [Article Type] Comment
Identifying potential drug targets and candidate drugs for COVID-19: biological networks and structural modeling approachesCOVID-19에 대한 잠재적 약물 표적 및 후보 약물 식별: 생물학적 네트워크 및 구조 모델링 접근법Research Article Published on 2021-05-172022-08-31 Journal: F1000Research [Category] MERS, 치료기술, 치료제, [키워드] acute respiratory syndrome addition Algorithm Analysis Antigen antigen processing approach BCL3 binding affinity Biological network analysis Biomarker Biomarkers candidate drug candidate drugs CBL CEBPB complex conducted coronavirus CoV CoV infection COVID-19 CRKL cytokine demonstrated docking result drug target drug targets ERBB4 expressed expression expression profile expression profiles facilitate flexibility growth factor growth factor receptor binding HDAC9 host cell host gene host immune system human pathogen identifying immune signaling pathway include indicated inhibit innate immune response interleukin interleukin-1 KLHL12 Limma macropinocytosis MAPK MAPK signaling medicated MHC class I modulation module molecular dynamics Molecular dynamics simulation molecular dynamics simulations mortality rate MYC NCOA3 network analysis pathway Pathways peptide PPI PPI network protein-protein docking protein-protein interaction receptor Receptor binding receptor signaling reduce regulate Replication respiratory Respiratory system retrieved SARS-CoV-2 SARS-CoV-2 pathogenesis selected Severe acute respiratory syndrome Signal transduction signal transduction pathways Signaling signaling pathways Smad3 SMURF1 stability stimulatory T cell T cell receptor tyrosine VEGFA Walktrap algorithm was selected wortmannin [DOI] 10.12688/f1000research.50850.3 PMC 바로가기 [Article Type] Research Article