Understanding the neurological implications of acute and long COVID using brain organoidsReview Published on 2023-07-012024-09-05 Journal: Disease Models & Mechanisms [Category] update2024, [키워드] brain organoids Long COVID Neurological affectations SARS-CoV-2 [DOI] 10.1242/dmm.050049 PMC 바로가기 [Article Type] Review
Cerebral Malaria Model Applying Human Brain OrganoidsArticle Published on 2023-03-232024-08-28 Journal: Cells [Category] 말라리아, [키워드] brain organoids cerebral malaria HBMEC activation human iPSCs Secretome Transcriptome
SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with SofosbuvirArticle Published on 2022-11-032022-11-15 Journal: PLoS Biology [Category] SARS, 치료제, [키워드] accompanied Affect alleviate alteration Antiviral antivirals Brain brain organoid brain organoids cell death cells cellular coronavirus 2 coronavirus disease cortical COVID-19 death determine drug excitatory food infect inhibit SARS-CoV-2 neurological manifestation Neurological symptoms neuronal neurons Newborn pandemic phenotype promote replicate Replication rescued respiratory respiratory illnesses SARS-CoV-2 sofosbuvir Treatment underlie variety WHO World Health Organization [DOI] 10.1371/journal.pbio.3001845 PMC 바로가기
Recapitulating influenza virus infection and facilitating antiviral and neuroprotective screening in tractable brain organoidsArticle Published on 2022-07-072023-06-14 Journal: Theranostics [Category] Fulltext, 신종인플루엔자, [키워드] Antiviral screening. brain organoids human pluripotent stem cells Influenza virus RNA transcriptomic profiling. [DOI] 10.7150/thno.75123 PMC 바로가기
Cellular mechanisms underlying neurological/neuropsychiatric manifestations of COVID-19COVID-19의 신경학적/신경정신과적 징후의 기저에 있는 세포 메커니즘Review Published on 2021-04-012022-09-12 Journal: Journal of medical virology [Category] Fulltext, MERS, 진단, [키워드] acute respiratory syndrome astrocytes Brain brain organoids Cell cells cellular mechanism clinical observation Clinical practice clinically Coronavirus-2 COVID-19 disease disorder effective strategy epithelial cells Evidence Future hematogenous indicate Infection iPS cells manifestation mechanism Mortality neural cells neuroinvasion Neuroinvasive Neurological symptom NEUROLOGY neurons Neuropsychiatric neuropsychiatry neurovirulence. pluripotent stem cells Research respiratory symptoms robust SARS-CoV-2 SARS-COV-2 infection severity specimens the disease Treatment understanding virus [DOI] 10.1002/jmv.26720 PMC 바로가기 [Article Type] Review
Neuroinvasion of SARS-CoV-2 in human and mouse brain인간과 쥐의 뇌에서 SARS-CoV-2의 신경 침범Article Published on 2021-03-012022-09-11 Journal: The Journal of Experimental Medicine [Category] SARS, 비임상, 진단, 치료기술, [키워드] ACE2 Affect antibody approach Autopsies Autopsy Brain brain organoids breath Central nervous system cerebrospinal fluid changes in CNS Consensus consequence cortical COVID-19 COVID-19 patient detect died direct infection Evidence evidence of feature human ACE2 Human brain Immune cell in vivo independent infect Infection infections interferon mice Neuroinvasive Neuron neuronal infection neurons organ system organ systems overexpressing Patient prevented probe respiratory Respiratory disease response SARS-CoV-2 SARS-CoV-2 neuroinvasion second type I interferon with infection [DOI] 10.1084/jem.20202135 PMC 바로가기 [Article Type] Article
ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular ResponseApoE-Isoform-Dependent SARS-CoV-2 Neurotropism 및 세포 반응Article Published on 2021-02-042022-09-11 Journal: Cell Stem Cell [Category] Fulltext, MERS, 진단, 치료제, [키워드] Alter Alzheimer disease Alzheimer's disease ApoE APOE4 Astrocyte astrocytes Brain brain organoids Cell co-culture COVID-19 COVID-19 severity COVID-19 susceptibility Culture cultures direct viral infection Effect elevated exhibited genetic risk factor help increased risk induced pluripotent stem cells Infection inhibit iPSCs Neuron neuron-astrocyte co-culture neurons nuclear fragmentation organoids Patient pluripotent stem cells populations Remdesivir response risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neurotropism SARS-CoV2 SARS-CoV2 infection severe COVID-19 severity stem cell tested Treatment understanding Viral viral infection [DOI] 10.1016/j.stem.2020.12.018 PMC 바로가기 [Article Type] Article
COVID-19 lessons from the dish: Dissecting CNS manifestations through brain organoids요리의 COVID-19 교훈: 뇌 오르가노이드를 통한 CNS 발현 분석Article Published on 2021-01-152022-09-12 Journal: The EMBO Journal [Category] MERS, SARS, 진단, [키워드] brain organoid brain organoids cellular and molecular CNS COVID-19 disease dissect highlight increasingly manifestation mechanism Neuron pathogenic recent respiratory tract SARS-CoV-2 SARS-COV-2 infection [DOI] 10.15252/embj.2020107213 PMC 바로가기 [Article Type] Article
Broadly Active Antiviral Compounds Disturb Zika Virus Progeny Release Rescuing Virus-Induced Toxicity in Brain OrganoidsArticle Published on 2020-12-292022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] active against acute respiratory syndrome Antiviral antiviral activity Antiviral compound Antiviral treatment antivirals Brain brain organoids Cell cells Compound coronavirus disease Ebola virus expand flavivirus hallmark impairing infect mechanism of action mode-of-action neurological defects neuronal new virus Organoid outbreak Particles pathogenic pathogenic RNA viruses phenotypic progenitor cells reduced Release rescued RNA virus RNA viruses SARS-CoV-2 small molecule inhibitor Spread therapeutic window transfer Virus life cycle WHO World Health Organization Zika Zika virus ZIKV [DOI] 10.3390/v13010037 PMC 바로가기 [Article Type] Article
SARS-CoV-2 targets neurons of 3D human brain organoidsArticle Published on 2020-10-152023-07-06 Journal: The EMBO Journal [Category] SARS, [키워드] brain organoids cell death neurons SARS-CoV-2 Tau pathology [DOI] 10.15252/embj.2020106230 PMC 바로가기