Potential of targeting host cell calcium dynamics to curtail SARS-CoV-2 infection and COVID-19 pathogenesisReview article Published on 2022-09-012022-10-05 Journal: Cell Calcium [Category] SARS, 신약개발, 임상, 치료제, [키워드] acting calcium Calcium signaling Clinical management clinical trial clinical trials coronavirus disease COVID-19 COVID-19 pathogenesis Critical curtail driving drug regimen Efficacy handling homeostasis host cell Host cell calcium dynamics identify impacted Infection interact management mechanisms molecular molecular mechanism pathway Potential Protein reducing Replication reported respiratory SARS-CoV-2 SARS-COV-2 infection severity Signaling signaling cascade small molecule the disease Transport vaccination [DOI] 10.1016/j.ceca.2022.102637 [Article Type] Review article
Lowered Quality of Life in Long COVID Is Predicted by Affective Symptoms, Chronic Fatigue Syndrome, Inflammation and Neuroimmunotoxic Pathways긴 COVID에서 삶의 질 저하가 정동 증상, 만성 피로 증후군, 염증 및 신경 면역 독성 경로에 의해 예측됩니다Article Published on 2022-08-192022-09-11 Journal: International Journal of Environmental Research an [Category] 바이오마커, [키워드] Activation acute infection Affect Anxiety AstraZeneca Biomarker body temperature calcium caspase caspase-1 chronic chronic fatigue syndrome controls COVID COVID-19 Depression domain Effect explained fatigue fatigue syndrome female fibromyalgia Health Organization IL-18 immune Inflammation inflammatory biomarkers insulin insulin resistance life Long Long COVID Myalgic encephalomyelitis/chronic fatigue syndrome myeloperoxidase neuro-immune neurotoxicity oxidative stress oxygen oxygen saturation participant pathway Pfizer physical predicted Protein psychiatry Psychiatry. Psychological Quality Quality of life rating scales recruited Regression serum severity Sex SpO2 subsequent Switzerland vaccination variance Version World Health Organization yielding [DOI] 10.3390/ijerph191610362 PMC 바로가기 [Article Type] Article
Systematic review and meta-analysis on coronary calcifications in COVID-19코로나19의 관상동맥 석회화에 대한 체계적 고찰 및 메타분석Review Published on 2022-08-012022-09-11 Journal: Emergency Radiology [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI appear Biomarker Biomarker imaging CAC CAC-DRS CACS calcium cardiovascular Cardiovascular calcifications cardiovascular disease Cardiovascular events Chest CT Clinical outcome clinical outcomes Coronary Coronary calcifications. COVID-19 COVID-19 patient COVID-19 patients detect disease Evidence hospital Hospital mortality Hospitalization Infection Meta-analysis Mortality Neutral Non-pulmonary observational study outcome Predictive prognostic pulmonary involvement radiological finding reported respiratory outcomes SARS-CoV2 SARS-CoV2 infection ventilatory support [DOI] 10.1007/s10140-022-02048-y PMC 바로가기 [Article Type] Review
Cardiovascular drugs and COVID-19 clinical outcomes: a systematic review and meta-analysis of randomized controlled trials심혈관계 약물 및 코로나19 임상 결과: 무작위 대조 시험의 체계적인 검토 및 메타 분석Review Published on 2022-08-012022-09-11 Journal: British Journal of Clinical Pharmacology [Category] 임상, 진단, [키워드] 95% CI 95% confidence interval Accuracy ACEi ACEIs amlodipine angiotensin angiotensin receptor blocker angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors Anticoagulants anticoagulation antiplatelet approved ARBs Aspirin atorvastatin baseline blocker calcium calcium channel calcium channel blockers cardiovascular cardiovascular drugs Clinical outcome Completeness COVID-19 COVID-19 severity database drug Evidence had no Hospitalization identify initiated investigated Living systematic review mean difference meta-analyses Meta-analysis Meta-analysis. moderate Mortality no effect not affect observational studies observational study Other outcomes Prevent Quantitative Randomized controlled trial RCT RCTs receptor receptor blocker reported risk risk ratio searched severity sulodexide systematic review therapeutic therapeutic anticoagulation treat Trial trials [DOI] 10.1111/bcp.15331 PMC 바로가기 [Article Type] Review
Obesity contributes to mortality and displays alterations in calcium, urea and hemoglobin levels in SARS-CoV-2 infected individualsReview Published on 2022-08-012023-07-10 Journal: Clinical nutrition ESPEN [Category] COVID19(2023년), [키워드] Age of death calcium COVID-19 obesity. [DOI] 10.1016/j.clnesp.2022.05.024 PMC 바로가기 [Article Type] Review
Hypocalcemia: A key biomarker in hospitalized COVID-19 patientsResearch article Published on 2022-08-012022-10-05 Journal: Biomedical journal [Category] SARS, 바이오마커, [키워드] addition Admission adult subject Arterial hypertension association Biochemical biomarkers Biomarker blood biochemical calcium calcium concentration Cancer cardiovascular diseases China Chronic diseases Chronic kidney disease chronic obstructive CKD clinical complication Cohort collected Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CVD diabetes effective enrolled evaluated hospital hospitalizations hospitalized COVID-19 patient Hypocalcemia identify indicated ionized calcium mandatory material mechanical ventilation obesity outcome parameter Pathologies pathology patients poor prognosis positive correlation presence of comorbidity Previous studies profile Prognosis prognostic biomarker pulmonary disease Result SARS-CoV2 serum severity syndrome the disease [DOI] 10.1016/j.bj.2022.08.005 [Article Type] Research article
COVID-19 Severity and Mortality in Two Pandemic Waves in Poland and Predictors of Poor Outcomes of SARS-CoV-2 Infection in Hospitalized Young Adults폴란드의 두 가지 유행성 전염병의 COVID-19 심각도 및 사망률과 입원한 젊은 성인의 SARS-CoV-2 감염의 나쁜 결과 예측Article Published on 2022-07-312022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] addition Adults adults hospitalized albumin Alpha Alpha variant analyzed blood cell blood cell counts C-reactive protein calcium Characteristics Clinical characteristics Comorbidities COVID-19 COVID-19 severity creatine creatine kinase creatinine D-dimer debatable decrease disease severity Factors filtration rate global public health glomerular filtration rate had no hematocrit hemoglobin Hospitalization identify increase in intensive care intensive care unit treatment interleukin interleukin-6 investigated Laboratory Lactate lactate dehydrogenase Leukocytosis Logistic regression lung involvement lymphocyte lymphopenia mechanical ventilation Mortality Myoglobin neutrophil Neutrophil-to-lymphocyte ratio neutrophilia no increase non-survivor obesity outcome pandemic Patient peptide performed Poland Poor predictor predictors procalcitonin red blood cell Retrospective study risk of death SARS-CoV-2 SARS-CoV-2 variants second wave severe COVID-19 severity survivor Treatment troponin I urea variant Vitamin Vitamin D3 Wave with COVID-19 Young adults. [DOI] 10.3390/v14081700 PMC 바로가기 [Article Type] Article
Why Omicron Variant of SARS-CoV-2 is Less Fatal?SARS-CoV-2의 오미크론 변종이 덜 치명적인 이유는 무엇입니까?Article Published on 2022-07-052022-09-11 Journal: Chembiochem [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] addressed Amino acid amino acids article biochemical build calcium calcium oxalate chloride Deleterious mutations ENhance glycine insoluble less lysine mechanism Mutation mutations omicron Omicron variant omicron variant. oxalate Protein public health question residue residues SARS-CoV-2 Substitution valine variant variant of SARS-CoV-2 weakened [DOI] 10.1002/cbic.202200158 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Achieves Immune Escape by Destroying Mitochondrial Quality: Comprehensive Analysis of the Cellular Landscapes of Lung and Blood Specimens From Patients With COVID-19SARS-CoV-2, 미토콘드리아 품질을 파괴하여 면역 탈출 달성: COVID-19 환자의 폐 및 혈액 표본의 세포 환경에 대한 종합 분석Article Published on 2022-07-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] activated activating alveolar alveolar epithelial cell alveolar epithelial cells alveolar macrophage Alveolar macrophages analyzed antiviral immunity B cell B cells blocked Blood calcium cell count Comprehensive coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients crossfire cytokine Cytokine storm dataset Defense Degradation energy metabolism epithelial epithelial cell epithelial cells escape exacerbated excessive inflammation explain expression Gene Expression HIF1a Host IFI27 immune immune cells Immune escape Inflammation inhibited Interaction interferon landscape lung tissue Lungs Macrophage macrophages manifestation MCU metabolic pathway metabolism Mitochondria mitochondrial mitochondrial fission mitochondrial functions mitochondrial quality. pathway patients with COVID-19 Perspective plasma pro-inflammatory Regulatory T cell regulatory T cells released Replication respiratory capacity resulting RNA-sequencing SARS-CoV-2 significant changes in Single-cell RNA-sequencing T cells target transformation Tregs type I viral infection [DOI] 10.3389/fimmu.2022.946731 PMC 바로가기 [Article Type] Article
The Role of Vitamin D in SARS-CoV-2 Infection and Acute Kidney InjurySARS-CoV-2 감염 및 급성 신장 손상에서 비타민 D의 역할Review Published on 2022-07-012022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute kidney Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive addition AKI alveolar Anti-inflammatory Anti-inflammatory effects antioxidant benefit broad spectrum calcium Cell cell metabolism Chronic kidney disease CKD contribute Control coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) correlation COVID-19 COVID-19 severity Critically ill Critically ill patient critically ill patients cytokine release deficiency described Effects endothelial damage essential nutrient Genes homeostasis hormone in-hospital mortality Infection influence Innate immunity involved Kidney disease manifestation mechanism metabolism mitochondrial modulation molecular Mortality non-genomic nuclear outcome Pathologies Pathways phosphate proinflammatory recruitment regulate risk role SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severe coronavirus disease Side effects targets therapeutic strategy Toxicity Transcription Vitamin Vitamin D vitamin D deficiency vitamin D deficiency. vitamin D level vitamin D serum Vitamin D supplementation [DOI] 10.3390/ijms23137368 PMC 바로가기 [Article Type] Review