Capillaries – Communicable Diseases Research

SARS-CoV-2 Spike Proteins and Cell-Cell Communication Inhibits TFPI and Induces Thrombogenic Factors in Human Lung Microvascular Endothelial Cells and Neutrophils: Implications for COVID-19 Coagulopathy Pathogenesis

Article

Published on 2022-09-092022-11-16
Journal: International Journal of Molecular Sciences
[Category] SARS, 변종,

Myopathy as a cause of fatigue in long-term post-COVID-19 symptoms: Evidence of skeletal muscle histopathology

코로나19 이후 장기 증상에서 피로의 원인인 근병증: 골격근 조직병리학의 증거

Article

Published on 2022-09-012022-09-11
Journal: European journal of neurology
[Category] COVID19(2023년), SARS, 변종,

[키워드] ABC acute disease acute infection affected age analyzed Antigen basal lamina biopsy Capillaries capillary cells changes changes in COVID-19 symptoms Cytochrome C cytochrome c oxidase diagnosed disease electromyography electron microscopy evidence of expression fatigue fiber histological change histological changes histopathological Histopathology human leukocyte antigen indication indications Inflammation Injury less leukocyte long-term COVID Microscopy Mild mitochondrial Most patients muscle muscle biopsy muscle fiber muscle weakness muscular myalgia myopathic Myopathy Patient patients post-COVID syndrome. Quantitative reduced reported SARS-CoV-2 Skeletal muscle skeletal muscles Symptoms syndrome T lymphocyte T lymphocytes two patients variant variety weakness
[DOI] 10.1111/ene.15435 PMC 바로가기 [Article Type] Article

The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications

Article

Published on 2022-08-312022-11-15
Journal: Biochemical Journal
[Category] 진단,

TRPC6 is altered in COVID-19 pneumonia

TRPC6은 COVID-19 폐렴에서 변경됩니다.

Article

Published on 2022-08-012022-09-11
Journal: Chemico-biological interactions
[Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단,

[키워드] aggravate alveolar septa anatomical Capillaries cellular ciliated ciliated epithelium cough COVID COVID pneumonia COVID-19 COVID-19 pneumonia Dissection dissections distribution drugs Fever fibrosis Gene Expression Human human lung human lung tissue hyaline membrane hyaline membranes immunohistochemistry Inflammation inflammatory lesions inhibiting investigated involved lesions lung lung; molecular mechanism molecular mechanisms observation observations patients with COVID-19 Pneumonia pneumoniae processed Protein pulmonary inflammation reported Support Symptom target Therapies Therapy. tissue tissues TRP TRPC6 TRPC6 channels vessel wall was obtained
[DOI] 10.1016/j.cbi.2022.109982 PMC 바로가기 [Article Type] Article

Platelets in the NETworks interweaving inflammation and thrombosis

염증과 혈전을 뒤섞는 NETworks의 혈소판

Review

Published on 2022-08-012022-09-11
Journal: Frontiers in Immunology
[Category] 치료기술, 치료제,

[키워드] activate Bacterial Capillaries capillary characterized chemokine chemokines chromatin Clinical outcome Coagulation factors contribute contributing to Course COVID-19 COVID-19 pandemic COVID-19 patient Cytokine storm disease DNA engage ENhance Evidence expression Extracellular extracellular space Growth factors hemorrhage Hemostasis histone Histones host innate immunity immune response immunothrombosis IMPROVE increased mortality induce infiltration Inflammation Inflammatory diseases inflammatory signaling Interaction interface kill lesion lung majority mechanism microthrombi molecular mechanism NET NETs neutrophil neutrophil activation Neutrophil extracellular trap Neutrophil extracellular traps neutrophil infiltration Neutrophils other tissue other tissues pathogen Pathogens Pathways Patient Pattern recognition Pattern recognition receptors Platelet Platelets platelets. procoagulant Protein Proteins provide provided resulting signaling pathway subsequent surface expression survival target thrombi thrombosis thrombotic TLR2 TLR4 Topic TRAP Treatment vascular beds virus
[DOI] 10.3389/fimmu.2022.953129 PMC 바로가기 [Article Type] Review

Detailed videocapillaroscopic microvascular changes detectable in adult COVID-19 survivors

성인 COVID-19 생존자에서 감지할 수 있는 상세한 비디오모세혈관경 미세혈관 변화

Article

Published on 2022-07-012022-09-11
Journal: Microvascular research
[Category] COVID19(2023년), SARS, 치료기술, 치료제,

[키워드] age Analysis Angiogenesis Capillaries capillary cause change CNT concerning concomitant therapies contrary control group control groups control subject control subjects controls COVID-19 detectable disease disease onset disease severity Effect endothelial cells Endothelial dysfunction evaluate Frequency Giant Glucocorticoids induce less linear Microcirculation Multivariate analysis Nailfold capillaroscopy no statistically significant difference organ damage parameter Patient raynaud s phenomenon Raynaud's phenomenon reduced SARS-CoV-2 SARS-CoV-2. scored searched selective significantly significantly lower statistically significant difference survivor Therapies therapy
[DOI] 10.1016/j.mvr.2022.104361 PMC 바로가기 [Article Type] Article

Cutaneous Small-vessel Vasculitis after ChAdOx1 COVID-19 Vaccination: A Report of Five Cases

ChAdOx1 COVID-19 예방접종 후 피부 소혈관염: 5건의 보고

Case Reports

Published on 2022-06-012022-09-11
Journal: The international journal of lower extremity wound
[Category] COVID19(2023년), SARS, 치료기술,

[키워드] acute respiratory syndrome adverse event Affect Antihistamines arteries Arterioles Autoimmunity Capillaries ChAdOx1 ChAdOx1 COVID-19 vaccine clinician coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccination Cutaneous Cutaneous Small-vessel Vasculitis defined demonstrated detectable FIVE lesion lower limb lower limbs Methylprednisolone one patient organs pandemic Pathogenesis Patient pregnant women reaction report reported required SARS-CoV-2 Severe acute respiratory syndrome small blood vessels South Korea spread to Steroids Symptom upper limb upper limbs vaccination Vasculitis vasculitis. women
[DOI] 10.1177/15347346221078734 PMC 바로가기 [Article Type] Case Reports

The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling

SARS-CoV-2의 스파이크 단백질은 인테그린 α5β1 및 NF-κB 신호 전달을 통해 내피 염증을 유도합니다

Article

Published on 2022-03-012022-09-11
Journal: The Journal of Biological Chemistry
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] ACE2 activate Activation addition adhesion Adhesion Molecule administration bind Blood Capillaries CD45 Coagulation coagulation factor Coagulation factors COVID-19 Critical Cytokines dependent on domain dysfunction dysregulated edema Effects endothelial Endothelial cell endothelial cells Endothelial dysfunction expression FVIII hallmark hallmarks homeostasis ICAM1 IL-1β IL-6 in vivo increased expression Incubation induce Inflammation inflammatory phenotype inhibitor inhibitors integrin intravenous Intravenous administration intravitreal injection kidney leukocyte leukocytes liver lung maintain mechanism motif NF-κB NF-κB signaling nuclear translocation occur Peripheral blood peripheral blood leukocyte peripheral blood leukocytes permeability prevented Proinflammatory cytokine proinflammatory cytokines Receptor-binding domain responsible SARS-CoV-2 severe disease Signaling Spike protein spike protein of SARS-CoV-2 spike protein. subsequent target gene the receptor-binding domain the spike protein tissue tissues TNFα umbilical umbilical vein vascular effect vascular endothelial cells vascular inflammation vascular leakage VCAM1
[DOI] 10.1016/j.jbc.2022.101695 PMC 바로가기 [Article Type] Article

A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications

긴 코비드/PASC에서 아밀로이드 피브린 마이크로 클로트의 중심 역할 : 기원 및 치료 적 영향

Review

Published on 2022-02-252022-09-10
Journal: Biochemical Journal
[Category] COVID19(2023년), Fulltext, MERS, SARS, 치료기술, 치료제,

[키워드] acute COVID-19 amyloid anticoagulant therapy autoantibodies Blood Blood coagulation breathlessness Capillaries chronic fatigue syndrome clotting Coagulation Coagulopathies Coagulopathy COVID COVID-19 demographics disease entity disorders Encephalomyelitis fatigue fatigue syndrome FIBRIN fibrinogen fibrinolysis fluorescence microscope Health implication individual Infection Inflammation initial lead leads limit Long majority manifested Microscope PASC passage phenotype plasma Platelet platelet-poor plasma preliminary report Proteins proteolysis recognize red blood cell red blood cells referred to Regulatory removal SARS-COV-2 infection shown similarities similarity stain Symptom Symptoms syndrome terminology therapeutic these symptoms Thioflavin tissue damage Treatment
[DOI] 10.1042/BCJ20220016 PMC 바로가기 [Article Type] Review

Collapsing Focal Segmental Glomerulosclerosis in Viral Infections

바이러스 감염에서 국소 분절 사구체 경화증의 붕괴

Review

Published on 2022-01-132022-09-11
Journal: Frontiers in Immunology
[Category] 변종, 유전자 메커니즘,

[키워드] activated Acute kidney injury acute viral infection acute viral infections African AKI APOL 1 APOL1 appearance Capillaries cascade cellular characterized Collapsing contributing to COVAN COVID-19 cytokine cytomegalovirus described direct viral infection drug epithelial cells etiologies Evidence Focal focal segmental glomerulosclerosis focus function glomerular glomerular capillaries glomerulopathy glomerulosclerosis hemodynamic instability high risk HIV HIVAN hyperplastic hypertrophic immune response immune responses impairment Infection Injury Ischemia kidney Kidney disease Kidney failure knowledge obliteration Pathogenesis Patient podocyte Podocytes potential mechanism potential mechanisms progression Proteinuria renal epithelial cell risk SARS-CoV-2 SARS-COV-2 infection Segmental Severe case severe cases systemic immune response systemic immune responses systemic inflammatory variant Viral viral entry viral infection viral infections
[DOI] 10.3389/fimmu.2021.800074 PMC 바로가기 [Article Type] Review