CD40 ligand – Communicable Diseases Research

SARS-CoV-2 infection induces soluble platelet activation markers and PAI-1 in the early moderate stage of COVID-19

SARS-CoV-2 감염은 COVID-19의 초기 중등도 단계에서 가용성 혈소판 활성화 마커 및 PAI-1을 유도합니다

Article

Published on 2022-08-012022-09-11
Journal: International journal of laboratory hematology [Category] MERS, SARS, 바이오마커,

CD154 Expression Indicates T Cell Activation Following Tetanus Toxoid Vaccination of Horses

article

Published on 2022-04-302024-09-01
Journal: Frontiers in immunology [Category] 파상풍,

[키워드] antigen-specific CD40 ligand CD40L equine gp39 TRAP
[Article Type] article

DNA Based Vaccine Expressing SARS-CoV-2 Spike-CD40L Fusion Protein Confers Protection Against Challenge in a Syrian Hamster Model

SARS-CoV-2 스파이크-CD40L 융합 단백질을 발현하는 DNA 기반 백신은 시리아 햄스터 모델에서 공격에 대한 보호를 제공합니다

Immunology

Published on 2022-01-122022-09-12
Journal: Frontiers in Immunology [Category] 진단,

Phase 2, randomized, placebo-controlled trial of dapirolizumab pegol in patients with moderate-to-severe active systemic lupus erythematosus

Clinical Science

Published on 2021-11-062024-09-04
Journal: Rheumatology (Oxford, England) [Category] 대상포진,

[키워드] CD40 ligand dapirolizumab pegol Lupus SLE systemic lupus erythematosus
[DOI] 10.1093/rheumatology/keab381 PMC 바로가기 [Article Type] Clinical Science

Diverse Humoral Immune Responses in Younger and Older Adult COVID-19 Patients

Research Article

Published on 2021-06-292022-10-29
Journal: mBio [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome age Amino acid antibody antibody reactivity Antibody Response antigenic B.1.1.7 B.1.526 B1.351 CD40 ligand chemokine clinical outcomes Clinical severity clinical variables Cohort collected coronavirus Coronaviruses correlation COVID-19 cytokine Cytokine analysis EGF elevated Endemic Endemic coronaviruses epidermal epitope Epitopes Frame group growth factor HCoV-NL63 HCoV-OC43 human coronavirus OC43 Humoral immunity IgG antibody IL-10 IL-15 in vitro transcription individual interferon IP-10 mechanically ventilated membrane MERS-CoV Microarray Middle East Mutation nucleocapsid Older Older age older patient ORF overlap overlapping P.1 Patient patients probe profiles Protein Proteins Region respiratory syndrome coronavirus response SARS-CoV SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 spike SARS-CoV-2 variant selected serum sample significantly significantly higher subset systemic cytokine the N protein the S1 protein translation Ventilated Viral variants
[DOI] 10.1128/mBio.01229-21 PMC 바로가기 [Article Type] Research Article

Pulmonary Procoagulant and Innate Immune Responses in Critically Ill COVID-19 Patients

중환자 COVID-19 환자의 폐 응고 촉진제 및 선천성 면역 반응

Clinical Trial

Published on 2021-05-142022-09-12
Journal: Frontiers in Immunology [Category] SARS, 임상, 진단,

[키워드] activated Activation acute respiratory distress Antigen Biomarker bronchoalveolar Bronchoalveolar lavage fluid bronchoalveolar space C1-Inhibitor CD40 ligand chemokine Coagulation complement complexes COVID-19 COVID-19 patient Critically ill Cytokines declined domain evaluate FIVE Follow-up functional growth factor Growth factors healthy controls host response Ill implicated Inflammatory Inflammatory response inhibitor Innate innate immune response Local lung measurement mechanical ventilation mechanism objective P-selectin pathogenesis of COVID-19 pathway Patient patients patients with COVID-19 persistent ARDS plasma plasma sample procoagulant pulmonary rationale response Result severe COVID-19 significantly increased stratified syndrome systemic tissue type I ventilated patient were measured with COVID-19
[DOI] 10.3389/fimmu.2021.664209 PMC 바로가기 [Article Type] Clinical Trial

CXCL10 could drive longer duration of mechanical ventilation during COVID-19 ARDS

Research

Published on 2020-11-022022-11-01
Journal: Critical Care [Category] COVID-19,

[키워드] acute respiratory distress syndrome alarmin alveolar alveolar cell ARDS ARDS patients Biomarker Bronchoalveolar lavage CCL5 CD40 ligand cell-free mitochondrial DNA clinical Concentration concentrations confounders correlated correlation COVID-19 COVID-19 ARDS patient COVID-19 ARDS patients CXCL-10 CXCL1 CXCL10 CXCL2 DNA dysregulated immune response EGF elevated epithelial lining etiology evaluated feature GM-CSF granzyme B host response IL-10 IL-1β IL-8 immune response Inflammatory inflammatory mediator involved lung mechanical ventilation mitochondrial mitochondrial DNA no difference Non-COVID-19 outcome Pathogenesis plasma predict required Result SARS-CoV-2 significantly systemic inflammation targeting Therapeutic approach TRAIL two groups unique Ventilator-free days Viral load were measured
[DOI] 10.1186/s13054-020-03328-0 PMC 바로가기 [Article Type] Research

Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study

Research article

Published on 2020-06-302022-10-05
Journal: The Lancet. Haematology [Category] SARS, 바이오마커,

[키워드] 95% CI acute respiratory syndrome Anticoagulants Antigen association Asymptomatic Benign biochemical marker Biomarker CD40 ligand clinical outcomes Coagulation factors Coagulopathy Comparator group complications Concentration Control controls coronavirus correlated correlation COVID-19 Critical cross-sectional death determine elevated Endothelial cell endotheliopathy Enzymes Evidence Factor fibrinolytic finding funding greater hazard ratio hematology hospital hospital discharge hospitalised ICU ICU patient ICU Patients IMPROVE Injury intensive care involved Kaplan–Meier analysis laboratory result laboratory-confirmed likelihood marker mitigate Mortality non-critically ill patient non-hospitalised non-ICU non-ICU patients outcome P-selectin Pathogenesis Patient patients patients with COVID-19 platelet activation previous study progression recruited significantly suggested supported survival thrombotic vWF was used with COVID-19
[DOI] 10.1016/S2352-3026(20)30216-7 [Article Type] Research article

The influence of therapeutic vaccine candidate against HBeAg pEGFP-N1-C (472-507)-ecdCD40L on dendritic cells

Article

Published on 2018-01-012023-06-16
Journal: Acta virologica [Category] B형 간염,

[키워드] CD40 ligand dendritic cells hepatitis B virus e antigens therapeutic vaccines
[DOI] 10.4149/av_2018_205

Regulation of p53 and Rb Links the Alternative NF-κB Pathway to EZH2 Expression and Cell Senescence

p53 및 Rb의 조절은 대체 NF-κB 경로를 EZH2 발현 및 세포 노화에 연결합니다

Research Article

Published on 2014-09-252022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activated Activation alternative NF-κB pathway Analysis ANAPC1 c-Rel cancer cell Cancer cells CD40 CD40 ligand CD40L CDK4 CDK6 Cell cell cycle cell senescence cellular senescence ChIP chromatin immunoprecipitation chronic chronic lymphocytic leukemia classical complexes Crosstalk de-repression defined Degradation DEK dependent on Effect effector effectors expression EZH2 fibroblasts Hematological malignancies Hematological malignancy IKK IKKα induce inhibit investigated IκB IκBα knockdown leads Loss Lymphocytic leukemia mechanism microarray analysis microenvironment NEMO NF-κB NF-κB inducing kinase NF-κB pathway NF-κB2 NIK or canonical oxygen p100 p21WAF1 p52 p53 pathway patients phenotype Phosphorylation polycomb protein promote protein stability provide PSMA5 quantitative PCR RacGAP1 reactive oxygen species reactive oxygen specy regulate Regulation regulatory subunit RELA RelB repression retinoblastoma retinoblastoma protein ROS SASP senescence senescent siRNA solid tumors stability stimulated subset subunit subunits suppress suppression target gene Target genes the cell Tumor tumor suppressor tumorigenesis tumors tumour suppressor turn western blot Western blot analyses Western blot analysis wild type
[DOI] 10.1371/journal.pgen.1004642 PMC 바로가기 [Article Type] Research Article