Varicella-Zoster virus ORF9 is an antagonist of the DNA sensor cGASArticle Published on 2022-07-182023-06-01 Journal: The EMBO Journal [Category] Fulltext, 두창, 수두, 홍역, [키워드] cGAS DNA sensing ORF9 phase separation. Varicella-Zoster Virus [DOI] 10.15252/embj.2021109217 PMC 바로가기
Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics녹농균(Pseudomonas aeruginosa): 병인, 독성 인자, 항생제 내성, 숙주와의 상호 작용, 기술 발전 및 새로운 치료법Review Published on 2022-06-252022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, MERS, 유전자 메커니즘, [키워드] addition Antibiotic resistance Antibiotics antimicrobial autophagy Bacterial Bacterial pathogenesis bioinformatics burn wounds Cancer caused Cell signaling cGAS chronic obstructive clinically COPD COVID-19 CRISPR CRISPR-Ca cystic fibrosis Defense develop disorder drug drug resistance Drug screening effective effort Factor Factors fibrosis gram Host host defense host immune responses host-pathogen interaction immune immune responses immunodeficiency IMPROVE infect Infection infections Inflammasome Interaction intractable invasive LPS mammalian cell mechanism metabolomics molecular Non-coding RNAs opportunistic pathogen outer membrane P. aeruginosa pathogen Pathogenesis Pathways Patient platform Pseudomona Pseudomonas aeruginosa rapid progress Regulation Research scRNA-seq secretion Severe infection signaling pathways Strains therapy traits treat use of antibiotics Ventilation Vesicle virulence widespread [DOI] 10.1038/s41392-022-01056-1 PMC 바로가기 [Article Type] Review
High Expression of HERV-K (HML-2) Might Stimulate Interferon in COVID-19 PatientsHERV-K(HML-2)의 높은 발현은 COVID-19 환자에서 인터페론을 자극할 수 있습니다Article Published on 2022-05-072022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] activate activated Affect antiviral immunity blood sample Blood samples Cell cGAS chromosome collected COVID-19 COVID-19 patient COVID-19 patients distribution expressed expression Gene ontology Genes GO analysis healthy healthy controls HERV HERV-K HERV-K (HML-2) HML-2 Host human body IFIT1 IFN-I IFNB1 infected with SARS-CoV-2 Interaction interferon interferon. ISG15 mapped marker Next-generation sequencing pathway Patient qPCR regulate SARS-CoV-2 secretion STING Vero Vero cells was performed [DOI] 10.3390/v14050996 PMC 바로가기 [Article Type] Article
STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS)STING 효능제 diABZI, PANoptosis 및 DNA 매개 급성 호흡 곤란 증후군(ARDS) 유도Article Published on 2022-03-252022-09-11 Journal: Cell Death & Disease [Category] SARS, 치료법, [키워드] Activation acute lung inflammation acute respiratory distress AIM2 airway amplification amplifying Apoptosis apoptosis induction ARDS CASP8 caspase-3 cell death cGAS cleavage complex contribute Cytokines cytoplasm DDX41 dinucleotide Disruption DNA DNase I double-stranded dsDNA ENhance epithelial extracellular DNA followed by gasdermin D IFN IFN-I IFNAR1 IL-1β IL-6 immune response immune responses induce Infection inflammasomes Inflammation Inflammatory Inflammatory cytokine Inflammatory cytokines Inflammatory response interferon IRF3 low dose lung Lung inflammation mice MLKL necroptosis NET NETosis neutrophilic neutrophilic response NF-kB NF-kB pathway NLRP3 NLRP3 inflammasome nucleotide pathway Phosphorylation priming pro-inflammatory cytokine pro-inflammatory cytokines pyroptosis receptor RIPK3 SARS-COV-2 infection severe ARDS signaling pathway silica smoke stimulator STING subsequent suggested syndrome TBK1 therapeutic strategy TLR9 TNFR1 TNFα Treatment triggered Tumor tumors Type I IFN type I IFN response type I interferon upregulation viral infection ZBP1 [DOI] 10.1038/s41419-022-04664-5 PMC 바로가기 [Article Type] Article
The cGAS-STING pathway drives type I IFN immunopathology in COVID-19cGAS-STING 경로는 COVID-19에서 I형 IFN 면역병리를 유발합니다Article Published on 2022-03-012022-09-11 Journal: Nature [Category] SARS, 진단, 치료기술, 치료법, [키워드] activate addition caused cell death cGAS characterized ChIP Clinical outcome Complication Control COVID-19 Critical cyclic GMP cytosolic disease DNA Endothelial cell endothelial cell damage endothelial cells IFNs Immunity immunopathology IMPROVE increase in Infection infection with SARS-CoV-2 Inflammation interferon interferons interferons (IFNs late phase limit lung Lung inflammation Lung pathology Macrophage macrophages Manifestations mice mitochondrial mitochondrial DNA outcome Pathogenesis pathogenesis of COVID-19 pathway patients with COVID-19 pharmacological principle Profiling Rapid induction reduce response responses reveal SARS-CoV-2 severe lung inflammation STING sustained tissue Type Type I IFN type I IFN responses type I IFNs type I interferons virus propagation [DOI] 10.1038/s41586-022-04421-w PMC 바로가기 [Article Type] Article
Effect of Different Adjuvants on Immune Responses Elicited by Protein-Based Subunit Vaccines against SARS-CoV-2 and Its Delta VariantSARS-CoV-2 및 델타 변이체에 대한 단백질 기반 서브유닛 백신에 의해 유도된 면역 반응에 대한 다양한 보조제의 효과Article Published on 2022-02-282022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjuvant adjuvants aluminum Candidates caused cell culture supernatants cGAS coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine Delta delta variant Effect Efficacy elicited enhancing the immunogenicity facilitate global pandemic greater highest IgG1 IgG2a immunogenicity Infection manganese MF59 nanoparticle manganese Neutralizing antibodies neutralizing antibody pseudotyped SARS-CoV-2 RBD RBD-Fc RBD-specific IgG reduced response SARS-CoV-2 SARS-CoV-2 RBD severe acute respiratory syndrome Coronavirus STING subunit subunit vaccines Vaccine variants variants of concern variants. Viral load VoC [DOI] 10.3390/v14030501 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κBSARS-CoV-2 감염은 cGAS-STING 및 NF-κB를 통해 전염증성 사이토카인 반응을 유도합니다Article Published on 2022-01-122022-09-10 Journal: Communications Biology [Category] 치료기술, 치료제, [키워드] Activation antiviral responses block building Cell cGAS complications contribute cytokine cytokine secretion profile Cytokines death detect develop drugs epithelial cells evaluate evaluated global pandemic human epithelial cell human epithelial cells individual induce infected cell culture infected patients infections Inflammatory cytokine Inflammatory cytokines inflammatory immune response Inflammatory response Inflammatory responses IRF3 lead leads long-lasting lung damage majority Mild Mild disease NF-κB nuclear translocation Patient patient sera pro-inflammatory cytokine pro-inflammatory cytokines proportion SARS-CoV-2 SARS-CoV-2 infected cells SARS-COV-2 infection Severe case severe disease severe symptom severe symptoms Spread STING suppress Symptoms therapy transcriptional upregulation viral pathogenesis virus [DOI] 10.1038/s42003-021-02983-5 PMC 바로가기 [Article Type] Article
Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infectioncGAS에 의한 세포질 염색질 감지는 SARS-CoV-2 감염에서 타고난 면역 반응을 활성화합니다Article Published on 2021-11-032022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] ACE2 activate Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition caused Cell Cell fusion cellular cGAS chromatin contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytoplasmic cytosolic Defense DNA expression Host host antiviral response host antiviral responses host cell host cells host defense host immune system immune system induce infected cells Infectious diseases inhibit innate immune response innate immune system Innate immunity interferon knowledge MAVS mechanism nucleic acids nucleus offer pandemic pathway positive-sense RNA virus pro-inflammatory gene expression recognize reported required respiratory respond RNA virus SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Spike protein STING targeting therapeutic treating COVID-19 Trigger Viral viral infection viral replication Viral RNA [DOI] 10.1038/s41392-021-00800-3 PMC 바로가기 [Article Type] Article
Micronucleus production, activation of DNA damage response and cGAS-STING signaling in syncytia induced by SARS-CoV-2 infectionSARS-COV-2 감염에 의해 유도 된 Syncytia에서 미세 핵 생산, DNA 손상 반응의 활성화 및 CGAS- 스팅 신호 전달Research Published on 2021-10-212022-09-10 Journal: Biology Direct [Category] Fulltext, MERS, SARS, 유전자 메커니즘, [키워드] γH2Ax ACE2 Activation acute respiratory syndrome average Cell Cell fusion cellular cellular and molecular cGAS COVID-19 COVID-19 therapy DNA damage DNA damage signaling downstream dysregulated Effect explain expressing H2Ax help immune activation indicated induce lung tissue manifested mechanism Micronuclei micronucleus reported respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein Severe acute respiratory syndrome Signaling signaling pathway Spike protein STING Syncytia syncytia formation syncytium target Target genes the SARS-CoV-2 therapy translocation upregulation Viral viral infection [DOI] 10.1186/s13062-021-00305-7 PMC 바로가기 [Article Type] Research
cGAS-STING Signaling Pathway and Liver Disease: From Basic Research to Clinical PracticeReview Published on 2021-08-182023-08-30 Journal: Frontiers in Pharmacology [Category] E형 간염, [키워드] Cancer cGAS Inflammation liver STING [DOI] 10.3389/fphar.2021.719644 PMC 바로가기 [Article Type] Review