Persistent Salmonella infections in humans are associated with mutations in the BarA/SirA regulatory pathway인간의 지속적인 살모넬라 감염은 BarA/SirA 조절 경로의 돌연변이와 관련이 있습니다.Article Published on 2024-01-102024-08-21 Journal: Cell Host & Microbe [Category] 살모넬라증, [키워드] BarA/SirA chronic infections Genomics Host immune response persistence Salmonella enterica salmonellosis transcriptomics two-component regulatory system Virulence regulation
Invasive Non-Typhoidal Salmonella Lineage Biofilm Formation and Gallbladder Colonization Vary But Do Not Correlate Directly with Known Biofilm-Related Mutations침습성 비장티푸스 살모넬라 계통의 생물막 형성과 담낭 집락화는 다르지만 알려진 생물막 관련 돌연변이와 직접적으로 상관관계가 없다.Article Published on 2023-05-162024-08-22 Journal: Infection and Immunity [Category] 살모넬라증, [키워드] Biofilms Bloodstream infections chronic infections Gallbladder invasive microorganisms. Salmonella
Drivers of adaptive evolution during chronic SARS-CoV-2 infections만성 SARS-CoV-2 감염 중 적응 진화의 동인Article Published on 2022-07-012022-09-11 Journal: Nature Medicine [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptive antibody chronic infection chronic infections coronavirus correlated driver Drivers Evidence Evolution feature Hypothesis immune system Immunocompromised patient in some Infection MOST Most patients Mutation Patient patients Population reflected SARS-CoV-2 SARS-COV-2 infection searched Sequencing subset Substitution tested Transmissibility Transmission variants variants of concern VoC VOCs [DOI] 10.1038/s41591-022-01882-4 PMC 바로가기 [Article Type] Article
Pseudomonas aeruginosa modulates alginate biosynthesis and type VI secretion system in two critically ill COVID-19 patientsResearch Published on 2022-02-092022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] adaptive analyzed ancestors assays attenuate Bacteria bacterial pathogen bacterial superinfection biofilm caused chronic infections contribute COVID-19 COVID-19 patient COVID-19 patients critical COVID-19 patient Critically ill cytotoxicity Evolution facilitate genetic trait Health Host host cell host susceptibility immune clearance increase infected patient lung Macrophage marker mechanism microbial microenvironment modulate morbidity and mortality P. aeruginosa phenotypic Pneumonia Pseudomonas aeruginosa reactive oxygen specy reduced Result SARS-COV-2 infection secretion Sequencing analysis shift strain supplementary material the disease turn Type VI Secretion System viral infection virulence virus infection [DOI] 10.1186/s13578-022-00748-z PMC 바로가기 [Article Type] Research
Evolution of the SARS-CoV-2 genome and emergence of variants of concernSARS-CoV-2 게놈의 진화와 우려되는 변이체의 출현Review Published on 2022-02-012022-09-11 Journal: Archives of Virology [Category] COVID19(2023년), SARS, 변종, [키워드] accumulation Administered Alpha Antibody neutralization B.1.1.7 B.1.351 B.1.617.2 Beta change changes in chronic infections clade consequence coronavirus described Evolution immune response immune responses imperative Infection initial Lineage mortality rate mortality rates notable observation P.1 promote raised random Recombination recurrent infection Replication RNA SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 lineage segregation sequence sequence variation spike gene strain Strains Surveillance the SARS-CoV-2 genome the vaccine Transmission variants variants of concern Variation variations while whole-genome sequencing [DOI] 10.1007/s00705-021-05295-5 PMC 바로가기 [Article Type] Review
Molecular determinants of peaceful coexistence versus invasiveness of non-Typhoidal Salmonella: Implications in long-term side-effectsarticle Published on 2021-10-312024-09-01 Journal: Molecular Aspects of Medicine [Category] 살모넬라증, [키워드] chronic infections invasive NTS Long term sequelae Persisters Salmonella [Article Type] article
Torquetenovirus in saliva: A potential biomarker for SARS-CoV-2 infection?타액의 Torquetenovirus : SARS-COV-2 감염을위한 잠재적 인 바이오 마커?Research Article Published on 2021-08-242022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 바이오마커, [키워드] age amplification analyzed biological fluid biological fluids Biomarker both groups chronic infection chronic infections correlated COVID-19 diarrhea fatigue Fever Gender gene amplification group healthy individual healthy individuals Immune status individual likelihood Loss Loss of Smell marker mild respiratory symptoms nasopharynx negative controls positive positive individuals predict prevalent Prognosis provided remained resolved respiratory respiratory symptoms Saliva saliva samples SARS-CoV-2 SARS-CoV-2-positive individual SARS-CoV-2-positive individuals sore throat subject Symptom symptom duration symptom resolution the SARS-CoV-2 titer titers transplants was collected were assessed [DOI] 10.1371/journal.pone.0256357 PMC 바로가기 [Article Type] Research Article
Quantitative mapping of mRNA 3’ ends in Pseudomonas aeruginosa reveals a pervasive role for premature 3’ end formation in response to azithromycinPseudomonas aeruginosa에서 mRNA 3 '끝의 정량적 매핑은 아지트로 마이신에 대한 반응으로 조기 3'말단 형성에 대한 광범위한 역할을 보여줍니다.Research Article Published on 2021-07-122022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 3’ end accompanied accumulation Alter antibiotic Antibiotics approach Azithromycin azithromycin treatment cause change changes in chronic infection chronic infections clinical outcomes control gene Culture cystic fibrosis downregulated downregulated gene expression fibrosis Gene Expression Gene regulation Genes growth GTPase Hospital-acquired infection hospital-acquired infections hospitalized patient hospitalized patients immunocompromised individuals impair improve clinical outcome incidence Infection involved Macrolide mechanism molecular mechanism molecular mechanisms MOST mRNA nucleases nucleotide P . aeruginosa Patient persistence planktonic Premature promote provide Pseudomonas aeruginosa quorum reduced Regulation regulatory element respond resulting reveal RNA robust Stress stress response subject Support therapeutic intervention thought transcript Transcription transcriptional transcriptional response treated Treatment turn upregulated genes upregulating virulence [DOI] 10.1371/journal.pgen.1009634 PMC 바로가기 [Article Type] Research Article
T Cells Plead for Rejuvenation and Amplification; With the Brain’s Neurotransmitters and Neuropeptides We Can Make It Happen회춘과 증폭을 위한 T 세포 주장; 뇌의 신경전달물질과 신경펩티드로 우리는 그것을 실현할 수 있습니다Review Published on 2021-03-222022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] activate activated acute SARS-CoV-2 infection Adoptive Cell Therapy aging binding Brain Can Cancer Cell cell surface chemotactic chronic infections clinical trials CNS cytokine cytokine secretion damage decrease Depression diagnostic Dopamine Effect Effects Efficacy Ex vivo expressed extravasation Gene Expression Glutamate GnRH high risk Immunotherapy IMPROVE induce Infection infections Inflammation Injury integrin integrin-mediated killing limit microorganism microorganisms Migration Mortality natural Nerve-Driven Immunity nervous Neuropeptide Neuropeptide Y Neuropeptides neurotransmitter Neurotransmitters organization organizations other diseases other treatments overcome PD-1 proliferation protocols receptor Rejuvenation repeated SARS-COV-2 infection senescent Somatostatin Stress suggested System T cell T cells tested the cell therapeutic tissue repair trauma [DOI] 10.3389/fimmu.2021.617658 PMC 바로가기 [Article Type] Review
Persistent Bacterial Coinfection of a COVID-19 Patient Caused by a Genetically Adapted Pseudomonas aeruginosa Chronic Colonizer유전적으로 적응된 녹농균(Pseudomonas aeruginosa) 만성 집락자에 의한 COVID-19 환자의 지속적인 세균 동시 감염Cellular and Infection Microbiology Published on 2021-03-172022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 유전자 메커니즘, [키워드] Adapted adenine alginate Analysis Antibiotic resistance Bacteria biofilm cause chronic chronic infection chronic infections Coinfection collected component COVID-19 COVID-19 patient COVID-19 patients demonstrated differential gene expression analysis displaying DNA DNA methylation ENhance Epigenetic Exacerbation Extracellular matrix flagellar Gene expression analysis Genes genomic high mortality rate hospital Immunocompromised Immunocompromised patient Immunocompromised patients in vivo indicated isolate leads marker Methylation morphology opportunistic pathogen overproducing P. aeruginosa pathogen Patient performed persistent phenotypic predicted Pseudomonas aeruginosa quorum reducing SARS-CoV-2 Sequencing severe COVID-19 transcriptional regulation transcriptomic variant virulence [DOI] 10.3389/fcimb.2021.641920 PMC 바로가기 [Article Type] Cellular and Infection Microbiology