Screening of Small-Molecule Libraries Using SARS-CoV-2-Derived Sequences Identifies Novel Furin InhibitorsArticle Published on 2024-05-072024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] cleavage envelope glycoprotein exosite furin HTS in vitro inhibitor peptide protease SARS-CoV-2 virus [DOI] 10.3390/ijms25105079 PMC 바로가기 [Article Type] Article
SARS-CoV-2 main protease cleaves MAGED2 to antagonize host antiviral defensearticle Published on 2023-07-132024-09-05 Journal: mBio [Category] update2024, [키워드] cleavage MAGED2 main protease nucleocapsid protein SARS-CoV-2 viral replication [DOI] 10.1128/mbio.01373-23 PMC 바로가기 [Article Type] article
The main protease of SARS-CoV-2 cleaves histone deacetylases and DCP1A, attenuating the immune defense of the interferon-stimulated genesResearch Article Published on 2023-02-082024-09-05 Journal: Brain stimulation [Category] update2024, [키워드] cleavage COVID-19, Coronavirus disease 2019 Cp, cleavage product CP, cleaved peptide DCP1A, mRNA-decapping enzyme 1a GBP1, guanylate binding protein 1 HDAC, histone deacetylase histone deacetylases IFIT, interferon-induced protein with tetratricopeptide repeats IFN, interferon interferon-stimulated gene IRF9, interferon regulatory factor 9 ISG, Interferon-stimulated gene ISGF3, interferon-stimulated gene factor 3 ISRE, interferon-stimulated response element Mpro, main protease main protease MIX, mix paired-like homeobox mRNA-decapping enzyme 1a OAS, 2′,5′-oligoadenylate synthetase PDCoV, porcine deltacoronavirus SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 STAT, Signal transducer and activator of transcription Usp18, ubiquitin specific peptidase 18 [DOI] 10.1016/j.jbc.2023.102990 PMC 바로가기 [Article Type] Research Article
Host antiviral factors hijack furin to block SARS-CoV-2, ebola virus, and HIV-1 glycoproteins cleavagearticle Published on 2023-02-012024-09-05 Journal: Emerging Microbes & Infections [Category] update2024, [키워드] antiviral factors cleavage furin SARS-CoV-2 viral glycoprotein [DOI] 10.1080/22221751.2022.2164742 PMC 바로가기 [Article Type] article
Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA.1 and BA.2Article Published on 2022-12-012022-11-16 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] change changes in Characteristics circulating cleavage contribute contributing to demonstrated dependent on determinant endosomal entry endosomal entry pathway endosomal pathway Entry facilitate feature Fusogenicity H655Y identify increase investigated less Mutation omicron Omicron BA.1 and BA.2 Pathogenesis pathogenicity plasma membrane predominant Proteases recent reduce reduced retained SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 WT serine protease spike spike mutation Spike protein spike protein cleavage. subsequent the spike protein TMPRSS2 transmembrane serine protease Virological virus entry [DOI] 10.1080/22221751.2022.2117098 PMC 바로가기
Label-free Sensing of Main Protease Activity of SARS-CoV-2 with an Aerolysin NanoporeArticle Published on 2022-11-022022-11-15 Journal: Chemistry, an Asian journal [Category] SARS, 치료기술, [키워드] activity acute respiratory syndrome amplification Biomarker cleavage cleaved Concentration conserved coronavirus Critical diagnostic enzyme events exhibited expand M pro MPro Nanopore peptide produced protease Replication SARS-CoV-2 sensitivity sensors translocated viruses [DOI] 10.1002/asia.202200747 PMC 바로가기
Repurposing of HIV/HCV protease inhibitors against SARS-CoV-2 3CLproArticle Published on 2022-11-012022-11-15 Journal: Antiviral Research [Category] SARS, 변종, 신약개발, 치료제, [키워드] 3CL pro 3CLpro acute respiratory syndrome Anti-coronavirus drug antiviral drug applied caused cleavage Compound coronavirus COVID-19 outbreak dose-dependent manner Efficiency energy transfer exhibited feasibility HCV in vitro inhibited inhibitor inhibitors Mutation omicron pathogen predicted protease Protease inhibitor protease inhibitors quantification reproducibility repurposing SARS-CoV-2 Screening Screening assay severe acute respiratory syndrome coronavirus 2 Support variants virus replication [DOI] 10.1016/j.antiviral.2022.105419 PMC 바로가기
Biochemical Characterization of Emerging SARS-CoV-2 Nsp15 Endoribonuclease VariantsArticle Published on 2022-10-302022-11-16 Journal: Journal of Molecular Biology [Category] COVID19(2023년), SARS, 변종, [키워드] Affect Analysis analyzed biochemically bioinformatics catalytic caused changed characterization characterized cleavage Combination conserved coronavirus Coronaviruses Course COVID-19 pandemic domain drug design effort endoribonuclease endoribonuclease. EndoU evade Evolution facilitate Genome help Host immune response in vivo inactive increase in innate immune response middle monomeric Mutation N-terminal nonstructural proteins novel coronavirus SARS-CoV-2 Nsp15 oligomerization pandemic Patient prevalent Protein residue RNA SARS-CoV-2 SARS-CoV-2 sequence Sequencing Transcription triggering understanding variant viral genome Viral protein viral replication virus wild type [DOI] 10.1016/j.jmb.2022.167796 PMC 바로가기
Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airwaysArticle Published on 2022-10-152022-11-16 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, [키워드] airway airways Analysis Beta calu-3 cells cathepsin-dependent Cell cleavage cultured cells Essential furin Gamma host proteases in vivo infect Infection isolate mice mouse-adapted SARS-CoV-2 multiple pathway murine omicron pathway recent reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants shown significantly the spike protein TMPRSS2 variant [DOI] 10.1038/s41467-022-33911-8 PMC 바로가기
The Spike-Stabilizing D614G Mutation Interacts with S1/S2 Cleavage Site Mutations To Promote the Infectious Potential of SARS-CoV-2 VariantsArticle Published on 2022-10-122022-11-16 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome addition association carried Cell cleavage cleavage site cleaved coronavirus D614G D614G mutation Delta dependent on epistasis epistatic interaction evaluate expressing expression increasingly Mutation omicron pandemic pathogenic Potential Protein proteolytic proteolytic cleavage pseudovirions pseudovirus pseudoviruses remained resulting S1 subunit S1/S2 S1/S2 cleavage S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 variant Site spike spike mutation spikes Spread stabilizing effect successive wave Transmissibility variant variants variants of concern Viral particles viral spike viral variant virions wild-type Wuhan [DOI] 10.1128/jvi.01301-22 PMC 바로가기