Clinical evaluation of a dermatophyte RT-PCR assay and its impact on the turn-around-time: A prospective study피부사상균 RT-PCR 검사에 대한 임상 평가 및 결과 도출 시간에 미치는 영향: 전향적 연구Article Published on 2023-08-022024-08-17 Journal: Medical Mycology [Category] 백선증, [키워드] clinical evaluation dermatophytes Onychomycosis RT-PCR
The spectrum of clinical biomarkers in severe malaria and new avenues for exploration중증 말라리아에 대한 임상 바이오마커의 스펙트럼과 새로운 탐색 방법Article Published on 2022-12-012022-11-15 Journal: Virulence [Category] 말라리아, 바이오마커, [키워드] Biomarker Biomarkers C-reactive protein clinical evaluation clinical infections Clinical practice complement COVID-19 pandemic diagnostic Endemic Evidence Factor faster highlight host response Infection infections malaria MOST non-specific omics technology pathogen patients Plasmodium Plasmodium falciparum Platelet Pneumonia practicality Prognosis prognostic Prognostic biomarkers Protein public health Research Sample size severe malaria the disease therapeutic [DOI] 10.1080/21505594.2022.2056966 PMC 바로가기
Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cellsArticle Published on 2022-11-022022-11-15 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] Antiviral antivirals approved drug caused clinical evaluation Combination Compound concentrations conducted COVID-19 drug Effect Efficacy epithelial cell line exonuclease global pandemic HCV hepatitis C human lung human lung cell identify inhibitor moderate morbidity Mortality NS5A pharmacokinetic profiles Protein Remdesivir SARS Coronavirus SARS-CoV-2 SARS-CoV-2 replication Support synergy the SARS-CoV-2 therapeutic treatment strategy virus [DOI] 10.1038/s41598-022-21034-5 PMC 바로가기
Identification of hACE2-interacting sites in SARS-CoV-2 spike receptor binding domain for antiviral drugs screeningArticle Published on 2022-11-012022-11-15 Journal: Virus research [Category] SARS, 변종, 치료제, [키워드] amino acid residue antiviral drug binding binding sites. Cefixime Ceftazidime cell entry Cephalosporin derivative clinical evaluation coronavirus 2 Critical derivative drug Drug screening example hACE2 human Angiotensin-converting enzyme identification Infection inhibited Interaction key amino acid live SARS-CoV-2 molecular docking Mutation peptide Pseudotyped virus pseudovirus RBD Receptor binding domain respiratory Safe SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 Spike RBD Support targets tested the RBD the spike protein variants virus was determined wild type wildtype Wuhan [DOI] 10.1016/j.virusres.2022.198915 PMC 바로가기
Antiviral efficacy of favipiravir against Zika and SARS-CoV-2 viruses in non-human primates Research Published on 2022-08-302022-10-05 Journal: Nature Communications [Category] SARS, 임상, 치료기술, 치료법, 치료제, [키워드] animal model animal models antiviral activity Clinical efficacy clinical evaluation clinical trial COVID-19 pandemic cynomolgus macaques disease drug Efficacy euthanized evaluate evaluated Evidence Favipiravir High dose implementation in vitro in vitro result Infection initiated no effect non-human primate plasma rapid clinical deterioration RNA virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral kinetics SARS-CoV-2 virus statistically significant reduction Support tested translation treated viral kinetics Viral load worsening Zika Zika virus [DOI] 10.1038/s41467-022-32565-w [Article Type] Research
Vaccines based on the replication-deficient simian adenoviral vector ChAdOx1: Standardized template with key considerations for a risk/benefit assessmentResearch article Published on 2022-08-012022-10-05 Journal: Vaccine [Category] COVID19(2023년), SARS, 비임상, [키워드] adenoviral vector Adenovirus administration Antigen approved assessment benefit Benefit/Risk booster capillary leak syndrome cell line Cellular immune response ChAdOx1 circumvent clinical evaluation clinical trial collaboration conducted COVID-19 COVID-19 vaccination Deletion dose effective Emergency use authorization evaluate evaluated expressing Extensive feature fevers Genetic Guillain-barrè syndrome Hemorrhagic HIV humoral immune response Immune thrombocytopenia impair Influenza key consideration malaria manuscript MERS-CoV New Nipah virus Oxford-AstraZeneca platform pre-existing immunity Prophylactic Prostate cancer Replication reported risk Safety SARS-CoV-2 Serious Adverse Event serotype surveillance data syndrome therapeutic thrombosis Tuberculosis University of Oxford Vaccine Vaccine development Vaccines vectored vaccine virus Zika [DOI] 10.1016/j.vaccine.2022.06.008 [Article Type] Research article
Role of population and test characteristics in antigen-based SARS-CoV-2 diagnosis, Czechia, August to November 2021Article Published on 2022-08-012022-11-16 Journal: Eurosurveillance [Category] SARS, 변종, [키워드] age analysed Antigen approved Characteristics clinical evaluation common Department Diagnosis diagnostic Emergency European group highest incidence Infection Infectious disease list lowest National national study no symptoms PCR test PCR-negative PCR-positive rapid antigen test Rapid diagnostic test recorded Registered reported Result role Saliva SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 delta sensitivity Sensitivity and specificity subgroup Symptom Symptoms System union United Kingdom vaccination variant Viral load was recorded WHO World Health Organization [DOI] 10.2807/1560-7917.ES.2022.27.33.2200070 PMC 바로가기
Recombinant chimpanzee adenovirus vector vaccine expressing the spike protein provides effective and lasting protection against SARS-CoV-2 infection in mice스파이크 단백질을 발현하는 재조합 침팬지 아데노바이러스 벡터 백신은 생쥐에서 SARS-CoV-2 감염에 대해 효과적이고 지속적인 보호를 제공합니다Article Published on 2022-08-012022-09-11 Journal: Virologica Sinica [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Adenovirus Cellular immune response Chimpanzee Chimpanzee adenovirus vector clinical evaluation death dose dropped effective Effectiveness Efficacy expected expressing full-length global public health histological abnormalities histological abnormality histopathological examination humoral Humoral and cellular immune responses immune responses immunization immunized mice Infection Long-term protection lung Lungs mice Mild Neutralizing antibodies neutralizing antibody pandemic provide Rapid recombinant recombinant chimpanzee adenovirus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic short term the SARS-CoV-2 the spike protein vaccination Vaccine variants of concern vectored vaccine Viral Viral load widespread [DOI] 10.1016/j.virs.2022.05.006 PMC 바로가기 [Article Type] Article
Production and characterization of chimeric SARS-CoV-2 antigens based on the capsid protein of cowpea chlorotic mottle virus동백색 반점 바이러스의 캡시드 단백질을 기반으로 하는 키메라 SARS-CoV-2 항원의 생산 및 특성화Article Published on 2022-07-312022-09-11 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, [키워드] absence Antigen antigens BALB/c mice characterized chimeric Chimeric protein clinical evaluation COVID-19 pandemic Cowpea cultures develop E. coli Efficacy epitope Epitopes expressed expression full-length S protein Humoral response IgG antibody IgG antibody titer immunogenic Inclusion induce interfere mutant offer Pathogens plant plant virus Plant virus. Production Protein purified recognize resulting SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 spike protein spike Spike protein subunit Subunit vaccine subunit vaccines Support the SARS-CoV-2 the vaccine Vaccine vaccine candidate vaccine candidates vaccine platform virus VLP VLPs [DOI] 10.1016/j.ijbiomac.2022.06.021 PMC 바로가기 [Article Type] Article
Preparation of the luciferase-labeled antibody for improving the detection sensitivity of viral antigen바이러스 항원의 검출감도 향상을 위한 루시페라제 표지 항체의 제조Article Published on 2022-07-282022-09-11 Journal: Virology Journal [Category] COVID19(2023년), SARS, 치료기술, [키워드] antibody antigen detection antigens applied Automatic Automatic magnet chemiluminescence immune assay (AMCA) auxiliary chemiluminescence clinical evaluation clinical sensitivity detect detection antibody Detection sensitivity Diagnosis ELISA evaluated expected gold Highly sensitive HRP immune IMPROVE Improving inactivated labeled antibody labeling limit of detection luciferase monoclonal antibody nano luciferase nLuc pathogen PCR-negative PCR-positive peroxidase preparation produced reached reporter respiratory syndrome coronavirus respiratory syndrome coronavirus 2 SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 virus sensitivity significantly specificity Spike protein swab sample swab samples the SARS-CoV-2 Viral antigen viral infections viral spike protein virus virus antigens virus detection virus infection [DOI] 10.1186/s12985-022-01855-6 PMC 바로가기 [Article Type] Article