Prevalence of Coronavirus Disease 2019 (COVID-19) in Different Clinical Stages before the National COVID-19 Vaccination Programme in Malaysia: A Systematic Review and Meta-AnalysisReview Published on 2022-02-162022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] calculated clinical Clinical stage Clinical stages conducted country COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID-19 prevalence database death determine Diabetes Mellitus disease early phase Egger’s test examined exclusion criteria funnel plot heterogeneity highest hypertension Inclusion lowest Malaysia management Meta-analysis morbidity obesity occurred Patient patients performed Prevalence prevalence of COVID-19 prevalence rate Program recorded reported review scale severity Stage stage 2 suggested systematic literature search the disease vaccination Vaccination program was performed Web of Science [DOI] 10.3390/ijerph19042216 PMC 바로가기 [Article Type] Review
Emerging mutations in the SARS-CoV-2 variants and their role in antibody escape to small molecule-based therapeutic resistanceSARS-CoV-2 변이체의 새로운 돌연변이와 항체가 소분자 기반 치료 내성으로 탈출하는 역할Review Published on 2022-02-012022-09-11 Journal: Current opinion in pharmacology [Category] COVID19(2023년), SARS, 변종, [키워드] antibody Antiviral article candidate Clinical stages clinical trial clinical trials COVID-19 pandemic effective Genome identify Major Mutation mutations Neutralizing antibodies neutralizing antibody RdRP RdRp mutations Remdesivir SARS-CoV-2 variant SARS-CoV-2 variants small molecule the SARS-CoV-2 therapeutic variant [DOI] 10.1016/j.coph.2021.11.006 PMC 바로가기 [Article Type] Review
New Translational Trends in Personalized Medicine: Autologous Peripheral Blood Stem Cells and Plasma for COVID-19 PatientCase Report Published on 2022-01-102022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] acute respiratory distress Allograft ARDS arterial blood gas (ABG) autologous autologous plasma and peripheral blood stem cells benefit Blood caused clinical biochemistry and molecular clinical biology Clinical stages Community coronavirus 2 country COVID-19 COVID-19 infection COVID-19 pandemic Critical death deaths disease effective Health Health authority ICU Inconclusive individual infected patient intensive care unit involved Italy Laboratory medicine MOF mortality rate multiple organ failure New Patient peripheral Peripheral blood plasma Protective antibody protocol reported respiratory SARS-CoV-2 Sepsis specific treatment STEM stem cell stem cells survivor Survivors syndrome the vaccine therapeutic Therapies thromboembolic to define Treatment trend Vascular [DOI] 10.3390/jpm12010085 PMC 바로가기 [Article Type] Case Report
SARS-CoV2 infection in symptomatic patients: interest of serological tests and predictors of mortality: experience of DR Congo증상 환자의 SARS-COV2 감염 : 혈청 검사의 관심 및 사망률 예측 자 : DR Congo의 경험Research Article Published on 2022-01-042022-09-01 Journal: BMC Infectious Diseases [Category] SARS, 진단, 치료기술, [키워드] Admission approach ARDS best clinical Clinical stage Clinical stages Combination Concordance COVID-19 COVID-19 patient COVID-19 patients Cox regression Cycle threshold value death diagnostic Dyspnea evaluate expressed Factor greater hospital identify IgG IgM IgM/IgG increase in increased the risk Kappa coefficient Mortality Patient patients performed positive predict predictor recorded referred to Result RT-PCR SARS- CoV-2 SARS-CoV2 infection serological test Serological tests shown significantly Stage Support symptomatic Symptomatic patients treat university university hospital Viral Viral load were used WHO WHO classification [DOI] 10.1186/s12879-021-07003-9 PMC 바로가기 [Article Type] Research Article
Multi-targeting approach for nsp3, nsp9, nsp12 and nsp15 proteins of SARS-CoV-2 by Diosmin as illustrated by molecular docking and molecular dynamics simulation methodologies분자 도킹 및 분자 역학 시뮬레이션 방법론으로 설명된 Diosmin의 SARS-CoV-2의 nsp3, nsp9, nsp12 및 nsp15 단백질에 대한 다중 표적화 접근Article Published on 2021-11-012022-09-11 Journal: Methods (San Diego, Calif.) [Category] SARS, 치료제, [키워드] absence Analysis analyzed approach approved drug binding binding affinity binding efficiency binding free energy Chemical Clinical stage Clinical stages complexes Compound compounds coronavirus COVID-19 COVID-19 disease demonstrated Diosmin docking score drug Dynamics economic loss effective enzyme experiment FDA FDA-approved drugs food Food and Drug Administration free energy Glide Health highest binding affinity in-silico inhibitor library MD simulation methodology molecular docking molecular dynamics Molecular dynamics simulation multi-targeting non-structural protein non-structural proteins novel Novel coronavirus Nsp12 Nsp15 Nsp3 Nsp9 Protein Protein target protein targets SARS-CoV-2 Schrodinger selected stability target targeting therapeutic Treatment Virtual screening [DOI] 10.1016/j.ymeth.2021.02.017 PMC 바로가기 [Article Type] Article
Identification of high-risk COVID-19 patients using machine learningResearch Article Published on 2021-09-202022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] acute respiratory syndrome Algorithm assessment Care caused Clinical stages coronavirus COVID-19 COVID-19 infection COVID-19 patient database demographic data detect determine Health high accuracy high-risk patient hospital hypothesis-testing identification information machine-learning pandemic Patient produced professional public health crisis SARS-CoV-2 Treatment [DOI] 10.1371/journal.pone.0257234 PMC 바로가기 [Article Type] Research Article
The role of teicoplanin in the treatment of SARS‐CoV‐2 infection: A retrospective study in critically ill COVID‐19 patients (Tei‐COVID study)Observational Study Published on 2021-03-262022-10-04 Journal: Journal of medical virology [Category] SARS, 임상, 치료제, [키워드] acute respiratory syndrome analysed Analysis Antibiotics Antiviral antiviral activity Biochemical parameters BSI C‐reactive protein causative pathogen Clinical stages Cohort complementary control group controls coronavirus coronavirus disease correlated Course COVID COVID‐19 COVID‐19 patient COVID‐19 Critically ill Critically ill patient critically ill patients Day effective empiric antibiotic enrolled evaluate expressed glycopeptide Hospitalization Hospitalized ICU ICUs infected patient intensive care unit kidney lack Liver function lymphocyte mechanical ventilation Mortality onset of disease outcome pathogenic mechanism Patient patients Pneumonia Primary outcome reduced reducing Research respiratory viral infection retrospective Retrospective study SARS‐CoV‐2 SARS‐CoV‐2 several limitation Side effect significantly Staphylococcus aureus statistical statistical significance statistically significant difference suggested sustained Teicoplanin the disease therapeutic therapy treat treated Treatment two group viral clearance viral damage viral replication virus White blood cell [DOI] 10.1002/jmv.26925 PMC 바로가기 [Article Type] Observational Study
Differences of blood cells, lymphocyte subsets and cytokines in COVID-19 patients with different clinical stages: a network meta-analysis임상 단계가 다른 COVID-19 환자의 혈액 세포, 림프구 하위 집합 및 사이토카인의 차이점: 네트워크 메타 분석Meta-Analysis Published on 2021-02-082022-08-31 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, meta-analysis, [키워드] 95% CI Analysis Blood blood cell Blood cells CD19 CD3 CD4 CD8 Cell Clinical stages conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical critical patients cytokine Cytokines database determine difference elevated Guidance IL-10 IL-1β IL-6 immune Immune suppression Inflammatory inflammatory parameter Injury lymphocyte Lymphocyte subset Lymphocyte subsets mean difference Meta-analysis mild patients network Network meta-analysis neutrophil Patient patients performed Platelet progression Result searched severe and critical patients severity significantly significantly lower Spread Stata supplementary material susceptible cell the disease the mean Treatment WBC were used white White blood cell worsening [DOI] 10.1186/s12879-021-05847-9 PMC 바로가기 [Article Type] Meta-Analysis
Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19세로 전사체 분석은 COVID-19에서 회복하는 동안 강력한 T 세포 면역을 보여줍니다Article Published on 2020-12-242022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Analysis AP-1 Clinical features Clinical stages convalescence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 creation differentially expressed differentiation disease downregulated driven by event Genome informatics Humoral immunity immune protection immune regulation immune response immune responses Immunity indicated Infectious diseases long non-coding RNA longitudinal Messenger RNA messenger RNAs microRNA MicroRNAs miRNAs mononuclear cell mRNAs occurred Patient PBMC performed Peripheral blood regulatory network rehabilitation respiratory RNA sequencing robust SARS-CoV-2 severe acute respiratory syndrome Coronavirus signaling pathway significantly T cell T-cell activation Transcriptome Treatment type I interferon type I interferon response understanding [DOI] 10.1038/s41392-020-00457-4 PMC 바로가기 [Article Type] Article
SARS-CoV-2: Immune Response Elicited by Infection and Development of Vaccines and TreatmentsSARS-CoV-2: 감염 및 백신 및 치료제 개발로 유발되는 면역 반응Review Published on 2020-12-112022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome coronavirus addition administration affected antiparasitic antivirals approach approved caused characterized clinical clinical evidence clinical manifestation clinical manifestations Clinical stages clinical trial clinical trials contribute convalescent serum coronavirus coronavirus 2 coronavirus disease COVID-19 COVID-19 disease current therapy deaths described development disease distress drug dry cough effective Evidence exacerbated FDA Fever food Food and Drug Administration headache Health Organization Human Hydroxychloroquine immune Immune cell immune cells immune response immunological imperative Infection Infectious disease information mediators Migration monoclonal antibody monoclonal antibody therapy neutralize organ pandemic Phase III clinical trials potential therapy Prevent proinflammatory mediator proinflammatory mediators respiratory respiratory distress response SARS-CoV-2 SARS-CoV-2 patients severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe case severe cases Symptom tested therapy Treatment treatments Vaccine vaccine candidate Vaccines virus WHO World Health Organization [DOI] 10.3389/fimmu.2020.569760 PMC 바로가기 [Article Type] Review