Evaluation of individual and combined NLR, LMR and CLR ratio for prognosis disease severity and outcomes in patients with COVID-19COVID-19 환자의 질병 중증도 및 결과에 대한 개별 및 결합된 NLR, LMR 및 CLR 비율 평가Article Published on 2022-08-012022-09-11 Journal: International immunopharmacology [Category] 바이오마커, 진단, 치료기술, [키워드] Analysis C-reactive protein characterized CLR Combination Combined Combined markers COVID-19 COVID-19 cases COVID-19 disease COVID-19 patients Critically ill Deceased develop disease disease severity Efficacy healthy controls healthy subject healthy subjects Hospital admission Hospitalization ICU ill patient immunological parameter IMPROVE independent Inflammatory intensive care unit lymphocyte marker material Mild moderate Mortality multivariate logistic regression multivariate logistic regression analysis neutrophil neutrophil/lymphocyte ratio NLR non-ICU normal value outcome parameter pathology Patient patients with COVID-19 performed Peripheral blood Predictive Prognosis Prognostic factor Prominent resulting returned ROC SARS-CoV-2 severe disease Severe infection severity of COVID-19 [DOI] 10.1016/j.intimp.2022.108781 PMC 바로가기 [Article Type] Article
Prognostic Value of C-Reactive Protein to Lymphocyte Ratio (CLR) in Emergency Department Patients with SARS-CoV-2 InfectionArticle Published on 2021-12-022022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] Admission Analysis biochemical Biomarker carried CLR Cohort composed COVID-19 COVID-19 severity Department determine Diagnosis Emergency Factor France hospital Infection lymphocyte moderate Mortality multicenter Patient patients hospitalized predict prognostic biomarker Prognostic value Ratio Retrospective study SARS-CoV-2 SARS-COV-2 infection sensitivity severe COVID-19 severity Severity of infection significantly specificity systemic inflammatory processes threshold value [DOI] 10.3390/jpm11121274 PMC 바로가기 [Article Type] Article
Epigenetic glycosylation of SARS-CoV-2 impact viral infection through DC&L-SIGN receptorsArticle Published on 2021-11-112022-10-30 Journal: iScience [Category] COVID-19, [키워드] Abstract ACE2 acute respiratory syndrome Affect affinity Cell Cell Biology changed CLR CLRs co-expression coronavirus dependent on Epigenetic genetic code GlcNAc glycomics glycoprotein glycosylation high-mannose highlight host cell Immune escape Immunity Infection L-SIGN Man Modification post-translational modification postfusion producing receptor respiratory tract cells S trimer SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virion spike glycoprotein Spike protein supported trimer viral entry viral infection virion virions Virology virus while [DOI] 10.1016/j.isci.2021.103426 PMC 바로가기 [Article Type] Article
The Impact of the Coronavirus Disease 19 Pandemic on Early Pregnancy Outcomes Among Patients Undergoing In Vitro Fertilization TreatmentOriginal Article Published on 2021-10-042022-10-29 Journal: Women's Health Reports [Category] COVID-19, [키워드] Analysis CLR Cohort cohorts coronavirus COVID-19 COVID-19 transmission CPR cycle determine early pregnancy fertilization Impact initial material miscarriage no difference outcomes pandemic Patient performed Pregnancy pregnancy loss Pregnancy rate retrospective cohort study SARS-CoV-2 transmission transfer widespread [DOI] 10.1089/whr.2021.0054 PMC 바로가기 [Article Type] Original Article
DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist스파이크 당단백질의 DC/L-SIGN 인식은 SARS-CoV-2 트랜스 감염을 촉진하고 글리코미메틱 길항제에 의해 억제될 수 있습니다Research Article Published on 2021-05-202022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, SARS, 바이오마커, [키워드] ACE2 antigen-presenting cells authentic SARS-CoV-2 virus capture Cell cell lines cell surface CLR CLRs Concentration COVID-19 pathogenesis DC-SIGN defined described dissemination Effectiveness ENhance entry receptor envelope protein evaluated event examined Factor Final glycan glycosylation Host identify immune cells immunomodulation IMPROVE Infection inhibited innate immune response Interaction involved L-SIGN Langerin lung tissue mechanism molecular monocyte Monocytes mucosa opens pandemic Pathogens promote Protein pseudovirus receptor receptors recognize respiratory respiratory mucosa SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 spike protein SARS-CoV-2 virus SIGN spike spike glycoprotein Spike protein Spread T-lymphocytes target cell target cells tested the cell the SARS-CoV-2 These data trans transfer transmission rate unique Vero E6 VERO E6 cells Viral viral infection viral spike protein virus viruses while [DOI] 10.1371/journal.ppat.1009576 PMC 바로가기 [Article Type] Research Article
SARS–CoV-2 Immuno-Pathogenesis and Potential for Diverse Vaccines and Therapies: Opportunities and ChallengesReview Published on 2021-02-042022-10-30 Journal: Infectious Disease Reports [Category] COVID-19, [키워드] ACE2 acute respiratory distress Adaptive immune response angiotensin-converting enzyme 2 Antibody titers Asymptomatic CD147 challenge characterized cleavage CLR Coronavirus disease-19 COVID-19 Cytokine storm syndrome displaying domain dysregulation Effect Frame host immune system immune antagonism Immunopathogenesis immunopathology immunotherapies implicated include innate immune system Interaction life-threatening mechanism myeloid non-structural protein Novel coronavirus NRP1 nucleic acid vaccine opportunity Other pathology peptide Potential receptor reduced Research respiratory SARS-CoV-2 SARS-COV-2 infection spike glycoprotein syndrome Therapeutics Therapies therapy TMPRSS2 Treatment Vaccine Vaccines viral spread Viral variants virus Wuhan, China [DOI] 10.3390/idr13010013 PMC 바로가기 [Article Type] Review
Can SARS-CoV-2 Virus Use Multiple Receptors to Enter Host Cells?Review Published on 2021-01-202022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 Anti-viral immunity c-lectin type receptor Can carbohydrate catastrophic Cell CLR CLRs contribute coronavirus disease Coronavirus-2 COVD-19 COVID-19 demonstrated Dipeptidyl peptidase-4 engage ezrin Glucose glucose-regulated protein 78 glycosylated glycosylation GRP78 Health host cell immune immunopathological independent Infection Inflammation innate immune system Interaction mannose receptor Multiple N-glycans non-immune NRP1 Occurrence Protein receptor Recognition regulated reported responsible S protein SARS-CoV-2 SARS-CoV-2 S protein Spike protein Spread susceptibility the S protein therapeutic target TLR TLRs Toll-like receptor viral clearance viral surface [DOI] 10.3390/ijms22030992 PMC 바로가기 [Article Type] Review
Clinical Trial to Evaluate an Approved ITP Therapy Targeting Spleen Tyrosine Kinase (SYK) for Prevention and Treatment of COVID-19 Related ComplicationsConference abstract Published on 2020-11-042022-10-05 Journal: Blood [Category] 임상, [키워드] Activation Acute kidney injury acute lung injury acute respiratory distress AKI allergic ARDS Autoimmune capillary leak syndrome caused clinical clinical status clinical study CLR Complication complications COVID-19 COVID-19 patient COVID-19 patients current Cytokine storm Diseases disorders double-blind download downstream Efficacy and safety Endothelial cell equity evaluate evaluated Fc receptor figure fostamatinib Hospitalized hospitalized COVID-19 patients Hyperactivation immune complex immune system immune systems Immune thrombocytopenia immunomodulatory effect implicated improvement incidence inhibitor involved kidney kinase LPS lung master regulator metabolite monocyte mouse model Nadeem neutrophil other treatment pathogen pathway Patient patients patients treated phase placebo-controlled plasma Platelets Prevent prevention Progress Protective Randomized receptor reduced reference Result rheumatoid arthritis risk safety profile Signal transduction Standard of care SYK syndrome target targeting the cytokine storm therapeutic strategy Thromboembolic event Thromboembolic events thrombosis tissue damage treated Treatment Van [DOI] 10.1182/blood-2020-141045 [Article Type] Conference abstract
Classic Selective Sweeps Revealed by Massive Sequencing in Cattle소에서 대규모 시퀀싱으로 밝혀진 클래식 선택적 스윕Research Article Published on 2014-02-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major affected affecting allele among others Analysis ancestors applied approach association autosomal SNP candidate gene cattle classic CLR complementary complexity Composite current detect detectable disequilibrium Domestication ERBB4 Evidence faster fixation Fleckvieh followed by Genetic genetics Genome genome-wide association genomic genomic region help homozygosity Human identify iHS IMPROVE KIT life style likelihood ratio linkage Linkage disequilibrium massive MC1R MITF multiple statistical metrics NRG4 overlap Perspective phenotype Phenotypes physical Protein QTL mapping QTLs Ratio re-sequencing Region regions Result Revealed score sensory perception Sequencing sequencing technology significantly somatic cell somatic cell count speciation subsequent TAS2R16 temper thought TMEM132D traits utility whole genome Whole genome sequencing [DOI] 10.1371/journal.pgen.1004148 PMC 바로가기 [Article Type] Research Article
Glycans from avian influenza virus are recognized by chicken dendritic cells and are targets for the humoral immune response in chickenArticle Published on 2013-12-012023-06-02 Journal: Molecular immunology [Category] 조류인플루엔자, [키워드] (BM)-DC (bone marrow-derived) dendritic cell Ab AIV antibody Avian influenza virus beta-propiolactone BPL C-type lectin CLR DC-SIGN Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin dendritic cells Glycan-recognizing antibodies HA Haemagglutinin highly pathogenic horseradish peroxidase HP HRP IG Immunoglobulin lectins low pathogenic LP macrophage galactose-type lectin 1 macrophage mannose receptor MGL-1 MMR N-glycosylation sites NA neuraminidase NGS PAA polyacrylamide SA sialic acid [DOI] 10.1016/j.molimm.2013.06.007