Active metabolites combination therapies: towards the next paradigm for more efficient and more scientific Chinese medicinePharmacology Mini Review Published on 2024-04-182024-09-05 Journal: Frontiers in Pharmacology [Category] update2024, [키워드] active metabolites combination therapies Multi-omics Single cell analysis TCM formulae [DOI] 10.3389/fphar.2024.1392196 PMC 바로가기 [Article Type] Pharmacology Mini Review
Artemisia Extracts and Artemisinin-Based Antimalarials for COVID-19 Management: Could These Be Effective Antivirals for COVID-19 Treatment?COVID-19 관리를 위한 Artemisia 추출물 및 Artemisinin 기반 항말라리아제: 이것이 COVID-19 치료에 효과적인 항바이러스제일 수 있습니까?Review Published on 2022-06-142022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 말라리아, 신약개발, 치료제, [키워드] active against acts acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Anti-inflammatory effects Antiviral Artemisia Artemisinin artemisinins combination therapies coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 demonstrated derivative derivatives Drug repurposing Effect Effectiveness Evidence exhibit Extract IL-6 Infection Inflammation inhibiting interleukin-6 Invasion lung damage malaria other diseases oxidative stress pandemic positive reducing Replication SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe COVID-19 shown Symptoms the SARS-CoV-2 treat Treatment [DOI] 10.3390/molecules27123828 PMC 바로가기 [Article Type] Review
Optimal Drug Regimen and Combined Drug Therapy and Its Efficacy in the Treatment of COVID-19: A Within-Host Modeling Study최적의 약물 요법과 복합 약물 요법과 COVID-19 치료의 효능: 숙주 내 모델링 연구Article Published on 2022-05-192022-09-11 Journal: Acta biotheoretica [Category] COVID19(2023년), SARS, 치료제, [키워드] Administered administration Arbidol average basic reproduction number Cell Combination combination therapies combination therapy Combined Comparative Comparative effectiveness study COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 pathogenesis death drug Drug interventions drugs Effectiveness Efficacy help include infected cells infection-related mortality Inflammatory mediators interferon Intervention life-threatening Lopinavir Lopinavir/ritonavir mathematical medical intervention modeling number of infected Optimal control problem Optimal drug Regimen physician reduce regimen Remdesivir Ritonavir significantly Stage susceptible cell Treatment treatment of COVID-19 Viral load were used [DOI] 10.1007/s10441-022-09440-8 PMC 바로가기 [Article Type] Article
INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes새로 진단된 제1형 당뇨병을 가진 소아, 청소년 및 성인을 대상으로 한 임상시험 의약품 평가를 위한 INNODIA 마스터 프로토콜Article Published on 2022-05-182022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 바이오마커, [키워드] adaptive adolescents and adult backbone baseline benefit Beta-cell function Biomarker Biomarkers C-peptide children Clinical data clinical sample clinical samples clinical trials Combination combination therapies comparable control group Decline demonstrated determine diabete diabetes diagnosed dosage Efficacy Efficacy and safety Endpoint evaluate greater identification identify IMPROVE include individual investigational medicinal product lack Master protocol mechanistic data natural history participant phase Phase 2 phase 2 clinical trials phase 2 studies Phase 2 study phase 3 study Prevent prevention product provide response robust sample size calculation Stratification subsequent trials Type 1 diabetes Variation [DOI] 10.1186/s13063-022-06259-z PMC 바로가기 [Article Type] Article
In vitro evaluation of therapeutic antibodies against a SARS-CoV-2 Omicron B.1.1.529 isolateSARS-CoV-2 Omicron B.1.1.529 분리주에 대한 치료 항체의 시험관 내 평가Article Published on 2022-03-182022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 진단, [키워드] analyzed antibodies antibody B.1 B.1.1.529 BavPat1 cilgavimab Clinical efficacy combination therapies combination therapy D614G dose doses Efficacy eight evaluated loss of activity modify monoclonal antibodies monoclonal antibody neutralize Neutralizing Neutralizing activity omicron Omicron variant reduction reduction in resulting SARS-CoV-2 Sotrovimab spike glycoprotein Spread Substitution the antibody therapeutic therapeutic antibodies Tixagevimab Vaccine variant variant of SARS-CoV-2 [DOI] 10.1038/s41598-022-08559-5 PMC 바로가기 [Article Type] Article
Oral antivirals for the prevention and treatment of SARS-CoV-2 infectionSARS-CoV-2 감염 예방 및 치료를 위한 경구용 항바이러스제Article Published on 2022-03-012022-09-11 Journal: AIDS reviews [Category] SARS, 변종, 치료제, [키워드] advent Antiviral antiviral therapy antivirals benefit classical combination therapies combination therapy complications COVID-19 COVID-19 disease COVID-19 pandemic Disease progression dissemination Each early treatment Emergency use authorization escape mutant Formulation Infection landscape life-threatening Long-ActingAntivirals manifestation medications Medicine molnupiravir monoclonal antibodies monoclonal antibody Mutagenesis Nirmatrelvir offer oral Oral Remdesivir parenteral administration polymerase Prevent Prophylaxis protease protease inhibitors PROTECT provided reduce regulatory agencies regulatory agency Remdesivir required SARS-CoV-2 SARS-COV-2 infection severe COVID-19 disease small molecule treat Treatment Vaccine variant viral illnesses waning immunity [DOI] 10.24875/AIDSRev.22000001 PMC 바로가기 [Article Type] Article
Comparing Outcomes of Two Antiviral Therapy Combinations among COVID-19 PatientsCOVID-19 환자의 2 개의 항 바이러스 요법 조합의 결과 비교Comparative Study Published on 2022-01-072022-09-10 Journal: BioMed Research International [Category] 치료제, [키워드] antiviral therapies arrhythmia Arrhythmias Atazanavir Bilirubin both group both groups clinical outcomes Clinical symptoms Combination combination therapies combination therapy Complication COVID-19 COVID-19 patients drug during treatment evaluated form Hospital stay Hydroxychloroquine hyperbilirubinemia Lopinavir Lopinavir/ritonavir no significant difference Other outcome patients patients with moderate Protease inhibitor regimen Ritonavir Side effect significant increase significantly statistically significant therapeutic Treatment treatment regimens two group two groups [DOI] 10.1155/2022/1522426 PMC 바로가기 [Article Type] Comparative Study
Data-driven multi-scale mathematical modeling of SARS-CoV-2 infection reveals heterogeneity among COVID-19 patientsSARS-COV-2 감염의 데이터 중심의 다중 규모 수학적 모델링은 COVID-19 환자의 이질성을 나타냅니다.Research Article Published on 2021-11-242022-09-10 Journal: PLoS Computational Biology [Category] MERS, SARS, 치료제, [키워드] acute respiratory syndrome addition addressed Affect Analysis Antiviral antiviral therapy Asymptomatic Clinical data Combination combination therapies combination therapy coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus infections COVID-19 COVID-19 patient COVID-19 patients COVID-19 progression Critical Differential equations Disease progression Effect Efficacy evaluated exhibited Guidance heterogeneity heterogeneous highlight Host IFN IFN response immune responses Incubation period infected cell infected cells infected with SARS-CoV-2 infection process investigated lack late stage mathematical mathematical model moderate multicellular naïve T cell naïve T cells outcomes Patient patients production rate progression quantified Quantitative Quantitative analysis question respiratory reveal SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe patients severe symptom severe symptoms severity Simulation Stage suggested Symptom symptomatic Symptoms T cell T cell response T cell responses T cells the stage Therapeutic strategies therapeutic strategy therapy threshold transition treating COVID-19 patient treating COVID-19 patients Treatment strategies type I interferon Viral viral dynamics virus [DOI] 10.1371/journal.pcbi.1009587 PMC 바로가기 [Article Type] Research Article
Deep learning identifies synergistic drug combinations for treating COVID-19딥 러닝, COVID-19 치료를 위한 시너지 약물 조합 식별411 Published on 2021-09-282022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 치료제, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Antiviral antiviral activity antiviral therapies applied approach association available data caused Combination combination therapies coronavirus COVID-19 datasets death deep deep learning develop disease drug drug combination drug combinations Drug discovery drug synergy effective Efficacy identify imperative in silico in vitro information Interaction interactions lack mitigate network architecture not applicable occur offer other disease other diseases recent reduced Remdesivir reserpine respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus Significance significantly synergistic Synergistic drug combinations synergy targets the disease therapy Toxicity training data treating COVID-19 treatments for COVID-19 while [DOI] 10.1073/pnas.2105070118 PMC 바로가기 [Article Type] 411
Mesenchymal stem cell-based therapy and exosomes in COVID-19: current trends and prospectsReview Published on 2021-08-212022-10-29 Journal: Stem Cell Research & Therapy [Category] COVID-19, [키워드] activities acute respiratory distress acute respiratory syndrome administration Autoimmune benefit cause caused Cell clinical study clinical trial combination therapies coronavirus disease Coronavirus-2 COVID-19 Cytokine storm degenerative Diseases dose Effect exacerbated exaggerated immune response Exosome Exosomes Extracellular Genetic immune response immunomodulation immunomodulatory Inflammatory mesenchymal stem cell Mesenchymal stromal cell Modification morbidity Mortality MSC MSCs novel offer paracrine pathophysiology Population regenerative resulting SARS-CoV-2 supplementary material syndrome the cytokine storm therapeutic potential Therapies therapy Treatment Vesicle virus with COVID-19 [DOI] 10.1186/s13287-021-02542-z PMC 바로가기 [Article Type] Review