A molecular toolkit for heterologous protein secretion across Bacteroides speciesArticle Published on 2023-12-152024-09-05 Journal: bioRxiv [Category] update2024, [키워드] Antibody fragments bacterial therapeutics Bacteroides commensal bacteria drug delivery Live biotherapeutic products outer membrane vesicles protein secretion Synthetic biology therapeutic proteins [DOI] 10.1101/2023.12.14.571725 PMC 바로가기 [Article Type] Article
Antibody induction and immune response in nasal cavity by third dose of SARS-CoV-2 mRNA vaccinationarticle Published on 2023-07-132024-09-05 Journal: Virology Journal [Category] update2024, [키워드] commensal bacteria COVID-19 microbiota SARS-CoV-2 [DOI] 10.1186/s12985-023-02113-z PMC 바로가기 [Article Type] article
Temporal dynamics of oropharyngeal microbiome among SARS-CoV-2 patients reveals continued dysbiosis even after Viral Clearance Research Published on 2022-08-242022-10-05 Journal: NPJ Biofilms and Microbiomes [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome administration Antibiotics Azithromycin Bacteria Bacterial infection Bacterial sepsis bacterial species Chryseobacterium clinical Clinical diagnosis clinically commensal bacteria compensated Complication complications Coronavirus-2 elevated feature Firmicute global public health healthy controls Human include indicate individuals Infection Influenza Klebsiella lung Lung infection microbial Microbiome morbidity and mortality observation oral organism Oropharyngeal oropharynx outbreak pandemic persist Pneumonia present proportion Proteobacteria reduced respiratory virus response reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 positive individual secondary bacterial infection Sepsis shown stability Temporal the patient viral clearance [DOI] 10.1038/s41522-022-00330-y [Article Type] Research
Impact of COVID-19 Lockdown on the Nasopharyngeal Microbiota of Children and Adults Self-Confined at HomeCOVID-19 잠금이 집에서 자가격리 중인 어린이 및 성인의 비인두 미생물총에 미치는 영향Article Published on 2022-07-122022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] Actinomycetale Adults Bacterial Barcelona children commensal bacteria Corynebacterium COVID-19 COVID-19 cases COVID-19 severity cross-sectional cross-sectional study death determine Emergency Fusobacterium Government Haemophilus healthy home Impact incidence of COVID-19 lockdown measure microbiota nasopharyngeal nasopharyngeal microbiota. nasopharyngeal swabs nasopharynx non-infected pandemic Prevotella reduced reflected SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2 RNA Spain Spanish Staphylococcus state of emergency Streptococcus Swab were used [DOI] 10.3390/v14071521 PMC 바로가기 [Article Type] Article
Gut microbiota-derived synbiotic formula (SIM01) as a novel adjuvant therapy for COVID-19: An open-label pilot studyCOVID-19에 대한 새로운 보조 요법으로서 장내 미생물총 유래 신바이오틱 포뮬라(SIM01): 오픈 라벨 파일럿 연구Article Published on 2022-05-012022-09-12 Journal: Journal of gastroenterology and hepatology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Admission Analysis antibody formation Antibody Response bacterial specy bifidobacteria changes in commensal bacteria Control control group controls COVID-19 COVID-19 patient database Day develop discharge Effect fecal greater Gut gut microbiota healthy Hong Kong hospital hospitalised COVID-19 patients hospitalized COVID-19 patients IgG antibody IL-1ra immune dysfunction immune markers Immunity Immunological response IMPROVE independent Infectious disease Intervention M-CSF Macrophage MCP-1 metagenomic microbiota monocyte chemoattractant protein-1 nasopharyngeal nasopharyngeal viral load Necrosis Open-label outcome pathogen Patient pilot study plasma positive pro-inflammatory Probiotics proinflammatory protocol receive receiving reduced restored SARS-CoV-2 SARS-CoV-2 IgG antibody SARS-CoV-2 viral load severity of COVID-19 significant negative correlation significantly standard treatment Strains suggested therapy TNF-α were given [DOI] 10.1111/jgh.15796 PMC 바로가기 [Article Type] Article
Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients경증 COVID-19 환자에서 공개 cTfh 클론형을 확장하는 보존된 SARS-CoV-2 스파이크 에피토프 식별Article Published on 2021-12-062022-09-11 Journal: The Journal of Experimental Medicine [Category] MERS, SARS, 변종, 진단, [키워드] activate activated T cell activated T cells activating Adaptive immunity Antigen booster CD4+ T cell CD4+ T cells Cell characterized circulating commensal bacteria conserved COVID-19 epitope Epitopes expand follicular healthy donors HLA identification mild COVID-19 patient mild symptoms Patient prevalent Protective protective antibodies SARS-CoV-2 epitopes SARS-CoV-2 S SARS-CoV-2 spike subset T cell T cells TCR TCRs Tfh Tfh cell Tfh cells the SARS-CoV-2 variants [DOI] 10.1084/jem.20211327 PMC 바로가기 [Article Type] Article
Neuropsychiatric Ramifications of COVID-19: Short-Chain Fatty Acid Deficiency and Disturbance of Microbiota-Gut-Brain Axis SignalingReview Article Published on 2021-10-052022-10-27 Journal: BioMed Research International [Category] [키워드] accompanied ACE-2 acid alleviate Altered Anti-inflammatory anti-inflammatory function axis Bacteria binding Brain changes in characterized commensal bacteria Complication components contribute COVID-19 COVID-19 patient Critical decrease deficiency described diagnostic disorders disturbance evaluate fatty favor fecal fiber gastrointestinal symptoms Gut gut microbiota gut microbiota composition implicated increase in Inflammation metabolite microbial Neurological disorder Neuropsychiatric Pathogens Prevent producing proinflammatory Psychiatric ramification receptor recommendation Research risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptors SCFA signaling pathway supported systemic inflammation Transport turn viral presence [DOI] 10.1155/2021/7880448 PMC 바로가기 [Article Type] Review Article
Neuropsychiatric Ramifications of COVID-19: Short-Chain Fatty Acid Deficiency and Disturbance of Microbiota-Gut-Brain Axis SignalingReview Article Published on 2021-10-052022-10-27 Journal: BioMed Research International [Category] COVID-19, MERS, SARS, [키워드] accompanied ACE-2 acid alleviate Altered Anti-inflammatory anti-inflammatory function axis Bacteria binding Brain changes in characterized commensal bacteria Complication components contribute COVID-19 COVID-19 patient Critical decrease deficiency described diagnostic disorders disturbance evaluate fatty favor fecal fiber gastrointestinal symptoms Gut gut microbiota gut microbiota composition implicated increase in Inflammation metabolite microbial Neurological disorder Neuropsychiatric Pathogens Prevent producing proinflammatory Psychiatric ramification receptor recommendation Research risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptors SCFA signaling pathway supported systemic inflammation Transport turn viral presence [DOI] 10.1155/2021/7880448 PMC 바로가기 [Article Type] Review Article
Association between the nasopharyngeal microbiome and metabolome in patients with COVID-19Research article Published on 2021-09-012022-10-05 Journal: Synthetic and Systems Biotechnology [Category] 바이오마커, 유전자 메커니즘, [키워드] Analysis anti-SARS-CoV-2 association bacterial metabolite Blood characterized Cohort commensal bacteria COVID-19 COVID-19 patient COVID-19 patients disease enrolled feature identify infect information Interaction lactic acid Leptotrichia Local metabolome metabolomic analysis metagenomic Microbiome microbiota nasopharyngeal Nasopharyngeal microbiome Nasopharyngeal swab Non-COVID-19 Non-COVID-19 patients Patient patients with COVID-19 pharyngeal Prevotella provide reduced respiratory tract Result SARS-CoV-2 sera serum significantly Streptococcus susceptibility Urine were used [DOI] 10.1016/j.synbio.2021.06.002 [Article Type] Research article
Oral Bacteria Combined with an Intranasal Vaccine Protect from Influenza A Virus and SARS-CoV-2 Infection비강내 백신과 결합된 구강 박테리아는 인플루엔자 A 바이러스 및 SARS-CoV-2 감염으로부터 보호합니다Research Article Published on 2021-08-172022-09-12 Journal: mBio [Category] MERS, SARS, 신종인플루엔자, 진단, [키워드] activating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immune response adaptive immune responses adjuvant Administered administration Antibiotics Antibody Response Bacteria Bacterial bacterial pathogen Combined commensal bacteria coronavirus Critical demonstrated Disruption gut microbiota healthy immune responses Immunity induce Infection Influenza Influenza virus intranasal intranasal vaccine intranasally less lysozyme mucosal mucosal immunity mucosal surface MYD88 nasal oral oral cavity PAMPs pathogen-associated molecular pattern PROTECT SARS-CoV-2 severe acute respiratory syndrome Coronavirus signaling pathway significantly lower Vaccine Vaccines virus infection [DOI] 10.1128/mBio.01598-21 PMC 바로가기 [Article Type] Research Article