NMR Observation of Sulfhydryl Signals in SARS-CoV-2 Main Protease Aids Structural StudiesArticle Published on 2022-10-062022-11-15 Journal: Chembiochem [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 3CL pro AID aliphatic AlphaFold-Multimers amide antiviral drug target backbone binding Combination competitive binding drug design effective experiment High-resolution homodimeric identify Interaction Ligand ligand binding ligands M pro Mpro/3CLPro N-terminal NMR NMR spectroscopy peptides protease Protein protons remained reveal SARS-CoV-2 sequence signal solvent sulfhydryl thiol group variant [DOI] 10.1002/cbic.202200471 PMC 바로가기
CRISPR-Cas12a-mediated label-free electrochemical aptamer-based sensor for SARS-CoV-2 antigen detectionSARS-CoV-2 항원 검출을 위한 CRISPR-Cas12a 매개 무표지 전기화학 앱타머 기반 센서Article Published on 2022-08-012022-09-11 Journal: Bioelectrochemistry (Amsterdam, Netherlands) [Category] SARS, 치료기술, 치료법, [키워드] amplification Antigen aptamer Biomarkers cleavage competitive binding complex COVID-19 CRISPR CRISPR-Cas12a cross-reactivity diagnostic DNA electrochemical biosensor expand generate gold impedance in vitro nucleocapsid antigen Quantitative resulting Rolling circle amplification SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 nucleocapsid selective significant decrease significantly [DOI] 10.1016/j.bioelechem.2022.108105 PMC 바로가기 [Article Type] Article
Potential Anti-SARS-CoV-2 Activity of Pentosan Polysulfate and Mucopolysaccharide PolysulfateArticle Published on 2022-02-212022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] ACE2 activity addition angiotensin-converting enzyme 2 anti-SARS-CoV-2 activities antiviral activity binding Cell competitive binding Compound compounds COVID-19 pandemic Delta demonstrated domain evaluated exhibited fucoidans glycan glycans Health heparan sulfate heparin Host host cell host cell receptor in vitro inhibited Interaction killing MPS much lower Mucopolysaccharide mucopolysaccharide polysulfate new SARS-CoV-2 omicron Pentosan pentosan polysulfate Potential PPS Prevalence previous study Protein pseudotyped lentiviral particle pseudotyped viral particle RBD RBD binding S-protein SARS-CoV-2 SPR sulfated surface plasmon resonance variants variants of concern viral infectivity wild type wild-type [DOI] 10.3390/ph15020258 PMC 바로가기 [Article Type] Article
Anti-SARS-CoV-2 Activity of Rhamnan Sulfate from Monostroma nitidum모노 스트로마 니티 디움으로부터의 Rhamnan 설페이트의 항 -SARS-COV-2 활성Article Published on 2021-11-302022-08-31 Journal: Marine Drugs [Category] SARS, 변종, 치료제, [키워드] ACE2 activities activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral activity backbone binding Characteristics competitive binding coronavirus COVID-19 COVID-19 pandemic delta variant demonstrated enzyme evaluated fucoidans glycans Health heparan sulfate heparin Host host cell host cell receptor host cells in vitro Interaction investigated monosaccharide Monostroma much lower mutant nuclear nuclear magnetic resonance Particle pathogen polysaccharide previous study Protein RBD receptor Receptor binding domain respiratory responsible rhamnan sulfate rhamnose S-protein SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus Spike protein SPR sulfate sulfated surface plasmon surface plasmon resonance the SARS-CoV-2 two-dimensional variant variants Viral viral infectivity wild type [DOI] 10.3390/md19120685 PMC 바로가기 [Article Type] Article
Persistence of the Immune Responses and Cross-Neutralizing Activity With Variants of Concern Following 2 Doses of Adjuvanted SCB-2019 Coronavirus Disease 2019 VaccineArticle Published on 2021-11-222022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 변종, 진단, [키워드] ACE2 activity acute respiratory syndrome age angiotensin-converting enzyme 2 antibodies antibody B.1.1.7 B.1.351 Beta Clover competitive binding concern coronavirus coronavirus disease COVID-19 cross-neutralization cross-reactive Day demonstrated dose dose-dependent increase Gamma IgG IgG antibodies immune response immunogenicity Immunoglobulin neutralizing antibody Neutralizing titer P.1 persistence phase 1 study Placebo prefusion prevalent reported response SARS-CoV-2 SCB-2019 sera Spike protein titer vaccination Vaccine vaccine candidate variants of concern Volunteer waned wild-type SARS-CoV-2 Wuhan-Hu-1 [DOI] 10.1093/infdis/jiab447 PMC 바로가기
Ivermectin: a multifaceted drug of Nobel prize-honoured distinction with indicated efficacy against a new global scourge, COVID-19Review article Published on 2021-09-012022-10-05 Journal: New Microbes and New Infections [Category] 신약개발, [키워드] animal models Betacoronavirus Committee competitive binding controls correlated COVID-19 death Diseases distribution Efficacy H. pylori indicated Infectious disease Ivermectin mechanism Medicine Meta-analysis morbidity Mortality Mutant strains notable Physiology randomized clinical trial RCT RCTs reduction reductions in risk SARS-CoV-2 SARS-CoV-2 spike protein Seven Sharp Spike protein Treatment tropical yielding [DOI] 10.1016/j.nmni.2021.100924 [Article Type] Review article
Identification of natural compounds as SARS-CoV-2 entry inhibitors by molecular docking-based virtual screening with bio-layer interferometryArticle Published on 2021-08-142023-07-02 Journal: Pharmacological research [Category] SARS, [키워드] bio-layer interferometry competitive binding molecular docking Molecular dynamics simulation natural compounds SARS-CoV-2 [DOI] 10.1016/j.phrs.2021.105820 PMC 바로가기 [Article Type] Article
Potent Molecular Feature-based Neutralizing Monoclonal Antibodies as Promising Therapeutics Against SARS-CoV-2 InfectionMolecular Biosciences Published on 2021-05-312022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] Against anti-SARS-CoV-2 Anti-viral antibody cocktail Antiviral approach caused Cell characterized competitive binding complex convalescent plasma COVID-19 cross-neutralizing antibody database defined described develop disease effective Efficacy Efficiency effort Evidence FIVE group human-to-human transmission include Infectious disease inhibiting Mechanical mechanisms MERS-CoV mitigate molecular molecular mechanism of action molecular target neutralization neutralizing effect neutralizing monoclonal antibody New coronavirus pandemic potent Pseudotyped virus reported retrieved Safe SARS-CoV SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 S protein Spread Therapeutics Treatment Vaccine Vaccines viral spread virus wild-type Wuhan, China [DOI] 10.3389/fmolb.2021.670815 PMC 바로가기 [Article Type] Molecular Biosciences
A high-affinity RBD-targeting nanobody improves fusion partner’s potency against SARS-CoV-2고친화성 RBD 표적 나노바디는 SARS-CoV-2에 대한 융합 파트너의 효능을 향상시킵니다Research Article Published on 2021-03-032022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, COVID-19, SARS, [키워드] ACE2 ACE2-RBD binding addition Affinity maturation antibodies antibody attachment bind binding affinity Characteristics competitive binding conserved Crystallographic studies Crystallographic study displaying distal domain Effect effective effective strategy epitope epitope distal Epitopes fusing fusion strategy generate high-affinity synthetic nanobody host cells host receptor hotspot identify immunological IMPROVE in vitro increase infect Infection interface kDa library screening llama-derived single-chain nanobodies nanobodies nanobody nanomolar affinity neutralization activity Neutralizing Neutralizing activity Neutralizing antibodies offer potency probe Protein provide pseudovirus RBD RBD binding RBD-targeting nanobodies RBD-targeting nanobody RBM RBM-antibodies RBM-binders Receptor-binding domain receptor-binding motif recognize recognizing Research S RBD SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus simple simplicity single-chain antibody speed spike Spike protein spike receptor-binding domain SR31 structure-based design sybody target the receptor-binding domain the SARS-CoV-2 therapeutic tool protein toolkit two modestly neutralizing sybodies [DOI] 10.1371/journal.ppat.1009328 PMC 바로가기 [Article Type] Research Article
ACE2 in the Era of SARS-CoV-2: Controversies and Novel PerspectivesMolecular Biosciences Published on 2020-09-302022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] “cytokine storm” accumulates ACE ACE inhibitor ACE2 ACE2 expression ACE2 protein ACE2 receptor acute respiratory syndrome Administered Alter Angiotensin receptor blockers angiotensin-converting enzyme 2 antibodies appear binding biochemical Biochemistry cardioprotection cardiovascular system cellular clinical investigation competitive binding COVID-19 COVID-19 disease COVID-19 pandemic Cytokine storm determinant downregulation drugs Effect effort engage enzyme Epigenetic event Evidence exogenously forms glycosylation Host host cell membrane hypertension induce Infection initial Interaction intestine kidney knowledge limit Lung inflammation mammalian mechanism Medical conditions MicroRNAs modulation Neutralizing novel observation pathogenicity pathophysiological pathophysiology peptides Phosphorylation plasma membrane Protein reduce reduced regulated Replication respiratory tract responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 severe COVID-19 small molecule Spike protein Strategy subunits: S1 tissues transcriptional viral envelope viral genome virus virus entry [DOI] 10.3389/fmolb.2020.588618 PMC 바로가기 [Article Type] Molecular Biosciences