Complement C3
[용어속성] Term
Early prediction of COVID-19 patient survival by targeted plasma multi-omics and machine learning
Research article
Published on
Journal: Molecular & Cellular Proteomics : MCP [Category] COVID19(2023년), SARS, 바이오마커, 변종, 진단, 치료기술,
Journal: Molecular & Cellular Proteomics : MCP [Category] COVID19(2023년), SARS, 바이오마커, 변종, 진단, 치료기술,
[키워드] BSAbovine serum albumin COVID-19
Dickinson and Company
3-nitrophenylhydrazine
AAAamino acid analysis
Accuracy
ACDacid citrate dextrose
acetonitrile
acid citrate dextrose
ACNacetonitrile
Alpha 1-antichymotrypsin
Alpha-1-antichymotrypsin
amino acid analysis
analysis of variance
ANOVAanalysis of variance
APCS
APOA2
APOA4
APOH Beta-2-glycoprotein 1
Apolipoprotein A-IIAPOA4
Apolipoprotein A-IVAPOH Beta-2-glycoprotein 1
area under the curve
AUC
AUCarea under the curve
B2MBeta-2-microglobulin
BDBecton
Becton
Beta-2-microglobulin
BHTbutylated hydroxyl toluene
bovine serum albumin COVID-19
BQC19
building
butylated hydroxyl toluene
C-reactive protein
C1RLComplement C1r subcomponent-like protein
C2Complement C2
C3Complement C3
C4AComplement C4
C4b-binding protein alpha chain
C4BPAC4b-binding protein alpha chain
C5Complement C5
C7Complement C7
C9Complement C9
CAMPCathelicidin antimicrobial peptide
capillary zone electrophoresis
Carboxypeptidase B2
Cathelicidin antimicrobial peptide
CFBComplement factor B
CFHComplement factor H
Clinical Proteomic Tumor Analysis Consortium
Coagulation factor XIII A chain
Complement C1r subcomponent-like protein
Complement C2
Complement C3
Complement C4
Complement C5
Complement C7
Complement C9
Complement factor B
Complement factor H
Concentration
concentrations
Control
COVID-19 hospitalization
COVID-19 patient
CPB2Carboxypeptidase B2
CPTACClinical Proteomic Tumor Analysis Consortium
CRPC-reactive protein
CST3Cystatin-C
Cystatin-C
CZEcapillary zone electrophoresis
disease severity
dithiothreitol
DTTdithiothreitol
ECMOextracorporeal membrane oxygenation
extracorporeal membrane oxygenation
F13A1Coagulation factor XIII A chain
FAFormic acid
false discovery rate
FDRfalse discovery rate
FGAFibrinogen alpha chain
FGBFibrinogen beta chain
FGGFibrinogen gamma chain
Fibrinogen alpha chain
Fibrinogen beta chain
Fibrinogen gamma chain
FIVE
Formic acid
Gelsolin
Gene name /Protein nameAPCS
globe
GSNGelsolin
haptoglobin
Healthcare system
Heparin cofactor 2
Hospitalization
hospitalized COVID-19 patients
HPhaptoglobin
IAAiodoacetamide
ICUIntensive Care Unit
IGFALSInsulin-like growth factor-binding protein complex acid labile subunit
Insulin-like growth factor-binding protein complex acid labile subunit
intensive care unit
Inter-alpha-trypsin inhibitor heavy chain H2
Inter-alpha-trypsin inhibitor heavy chain H4
iodoacetamide
ITIH2Inter-alpha-trypsin inhibitor heavy chain H2
ITIH4Inter-alpha-trypsin inhibitor heavy chain H4
K3EDTAtripotassium ethylenediaminetetraacetic acid
L-(tosylamido-2-phenyl) ethyl chloromethyl ketoneTrisHCl
LC-MSliquid chromatography-mass spectrometry
LC/MRM-MSliquid chromatography/multiple reaction monitoring mass spectrometry
Leucine-rich alpha-2-glycoprotein
liquid chromatography-mass spectrometry
liquid chromatography/multiple reaction monitoring mass spectrometry
LLOQLower Limit of Quantitation
Lower Limit of Quantitation
LRG1Leucine-rich alpha-2-glycoprotein
lysoPClysophosphatidylcholine
lysophosphatidylcholine
MALDImatrix assisted laser desorption ionization
mass spectrometry
matrix assisted laser desorption ionization
MeOHmethanol
metabolite
methanol
Mortality
MSmass spectrometry
N-acetylmuramoyl-L-alanine amidase
Neuropilin-2
Non-survivors
NPH3-nitrophenylhydrazine
NRP2Neuropilin-2
patient survival
PBSPhosphatase buffered saline
PCAprincipal component analysis
PCRpolymerase chain reaction
PGLYRP2N-acetylmuramoyl-L-alanine amidase
phenylisothiocyanate
Phosphatase buffered saline
PITCphenylisothiocyanate
plasma
polymerase chain reaction
post-translational modification
predict
Predictive
PRG4Proteoglycan 4
principal component analysis
PROS1Vitamin K-dependent protein S
Protein
Proteoglycan 4
PTMpost-translational modification
QCquality control
Quality control
reversed phase ultrahigh performance liquid chromatography
robust
RP-UHPLCreversed phase ultrahigh performance liquid chromatography
SAA2Serum amyloid A-1 and A-2 proteins
SAA4Serum amyloid A-4 protein
SARS-CoV-2SIS
Scientific and Cultural Organization
Sequential Organ Failure AssessmentSPE
SERPINA1Alpha-1-antichymotrypsin
SERPINA3Alpha 1-antichymotrypsin
SERPIND1Heparin cofactor 2
Serum amyloid A-1 and A-2 proteins
Serum amyloid A-4 protein
Serum amyloid P-componentAPOA2
significant difference
SIS
SOFA
solid-phase extractionSVM
SPE
stable-isotope labeled internal standardSOFA
Stratification
Support Vector MachineTPCK
survival
survivor
SVM
The Universal Protein Resource
TPCK
Transthyretin
Treatment
tripotassium ethylenediaminetetraacetic acid
Tris (hydroxymethyl) aminomethane hydrochlorideUNESCO
TrisHCl
TTRTransthyretin
UNESCO
UniProtThe Universal Protein Resource
unique
United Nations EducationalScientific and Cultural Organization
Vascular cell adhesion protein 1
VCAM1Vascular cell adhesion protein 1
Vitamin K-dependent protein S
[DOI] 10.1016/j.mcpro.2022.100277 [Article Type] Research article
[DOI] 10.1016/j.mcpro.2022.100277 [Article Type] Research article
A Review of Alpha-1 Antitrypsin Binding Partners for Immune Regulation and Potential Therapeutic Application
Review
Published on
Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), MERS, SARS,
Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), MERS, SARS,
[키워드] alpha-1 antitrypsin
alpha-1 antitrypsin deficiency
anti-inflammatory activity
antitrypsin
application
binding
canonical
Cell
changes in
circulation
cleavage
Complement C3
complex
Coronavirus disease 2019 (COVID-19)
Critical
cytokine
Cytokines
disorder
electrostatic
hydrophobic
immune response
immunomodulatory
increasingly
innate immune
interactions
interleukin-6
mechanism
methionine
modulate
molecular
neutralise
partner
Potential
protease
Proteases
Protein
protein-protein interaction
reactive
residue
review
serine protease inhibitor
therapeutic
therapy
[DOI] 10.3390/ijms23052441 PMC 바로가기 [Article Type] Review
[DOI] 10.3390/ijms23052441 PMC 바로가기 [Article Type] Review
Post-COVID-19 arthritis: is it hyperinflammation or autoimmunity?
코로나19 이후 관절염: 과염증인가 자가면역인가?
Article
[키워드] 95% confidence interval
affected
Ankle
anti-nuclear antibodies
anti-nuclear antibody
arthralgia
Arthritis
association
Autoimmune
Autoimmune reaction
Autoimmunity
baseline
C-reactive protein
Complement C3
coronavirus disease
Coronavirus disease 2019
COVID-19
COVID-19 infection
CRP
described
erythrocyte sedimentation
erythrocyte sedimentation rate
ESR
etiology
hyperinflammation
Hyperinflammatory
IL-6
IL-6 level
IL-6 levels
Infection
Inflammatory
Inflammatory marker
inflammatory markers
interleukin
joints
knee
Level
management
manifestation
mechanism
Musculoskeletal
Odds ratio
old age
P-value
Patient
patients
peptide
peptides
predict
Prevalence
sedimentation rate
serologic marker
serologic markers
significant differences
significantly higher
smoking
Support
therapy
with COVID-19
wrist
[DOI] 10.1684/ecn.2021.0471 PMC 바로가기 [Article Type] Article
[DOI] 10.1684/ecn.2021.0471 PMC 바로가기 [Article Type] Article
Serum Complement C3 and C4 and COVID-19 Severity and Mortality: A Systematic Review and Meta-Analysis With Meta-Regression
혈청 보체 C3 및 C4 및 COVID-19 심각도 및 사망률: 메타 회귀를 사용한 체계적인 검토 및 메타 분석
Meta-Analysis
[키워드] 95% CI
95% confidence interval
Activation
Adult patients
albumin
Analysis
blood cell
C-reactive protein
C3
C4
calculated
certainty
certainty of evidence
CIs
clinical consequence
complement
Complement activation
Complement C3
complement components
complement system
components
Concentration
conducted
Continuous data
coronavirus
coronavirus disease
COVID-19
COVID-19 patient
COVID-19 patients
COVID-19 severity
criteria
CRP
D-dimer
direction
disease severity
effect size
Egger’s tests
eligibility criteria
English language
estimates
evaluate
Evidence
GRADE
heterogeneity
magnitude
measure
Meta-analysis
meta-regression
moderate
Mortality
Newcastle-Ottawa Scale
non-survivor
Patient
patients
performed
predict
PROSPERO
publication bias
random-effects model
Registration
registration number
Regression
review
searched
sensitivity analysis
serum
serum concentrations
severity
significantly
significantly lower
SMD
standardized mean difference
study heterogeneity
survival
survivor
systematic review
Web of Science
White blood cell
white blood cell count
[DOI] 10.3389/fimmu.2021.696085 PMC 바로가기 [Article Type] Meta-Analysis
[DOI] 10.3389/fimmu.2021.696085 PMC 바로가기 [Article Type] Meta-Analysis
Complement C3 identified as a unique risk factor for disease severity among young COVID-19 patients in Wuhan, China
Article
[키워드] 95% CI
adverse outcome
age
Analysis
analyzed
C-reactive protein (CRP
Characteristics
clinical
Clinical characteristics
Clinical outcome
collected
Comorbidities
Complement C3
covariate
COVID-19 patient
COVID-19 patients
Critical
disease course
disease severity
Diseases
Elderly patient
elderly patients
elevated
Factor
female
Gender
independent
influence
influences
interquartile range
laboratory data
lactate dehydrogenase
LDH
Logistic regression
Lymphocyte count
median age
medical records
Mild
multivariable analysis
Odds ratio
Patient
patients
performed
proportion
random
risk
risk factor
Risk factors
SAA
serum amyloid
severe COVID-19
severe disease course
significantly higher
single hospital
statistically
student
suggested
the mean
Treatment
unique
variable
Wuhan, China
[DOI] 10.1038/s41598-021-82810-3 PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s41598-021-82810-3 PMC 바로가기 [Article Type] Article
SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation
SARS-CoV-2는 JAK1/2 종속 국소 보체 과활성화를 유도합니다.
Research Articles
[키워드] ACE
activated
Activation
affecting
Alternative pathway
angiotensin
angiotensin converting enzyme
Antiviral
blocked
Bronchoalveolar lavage
C3 convertase
C3a
Cell
cell lines
clinical manifestation
Combination
combination therapy
complement
Complement activation
Complement C3
complement component
complement system
convertase
coronavirus disease
Coronavirus disease 2019
COVID-19
disease severity
disease-causing
driver
drug
entry receptor
epithelial cell
epithelial cells
expressed
expression
Genes
Gut
Hyperactivation
implicated
induce
infected cells
inhibited
inhibitor
interferon
JAK inhibitor
jak inhibitors
JAK1
kidney
kidneys
liver
Local
lung epithelial
Lung epithelial cells
Lungs
lymphoid
normalized
not affect
pathway
Pathways
patients
processing
produced
Protein
Remdesivir
respiratory epithelial cell
respiratory epithelial cells
ruxolitinib
SARS-CoV-2
SARS-COV-2 infection
severe COVID-19
Signaling
Stat1
the disease
tissues
transcript
Transcription
underlie
virus
[DOI] 10.1126/sciimmunol.abg0833 PMC 바로가기 [Article Type] Research Articles
[DOI] 10.1126/sciimmunol.abg0833 PMC 바로가기 [Article Type] Research Articles
Deregulated cellular circuits driving immunoglobulins and complement consumption associate with the severity of COVID-19 patients
코로나19 환자의 중증도와 관련된 면역글로불린 및 보체 소비를 유도하는 규제 완화된 세포 회로
Article
[키워드] Activation
Admission
B cells
C5a
cause
CD16
CD56
cellular
circulating
complement
Complement C3
COVID-19
COVID-19 patients
discharged
driving
follicular
healthy donors
helper T cell
Hospitalized
host immune system
humoral
Humoral immunity
IgA
IgG
IgG1
IgG3
IgM
immune response
Immunity
Immunoglobulin
immunoglobulins
Infection
investigated
isotypes
lymphopenia
Mild
moderate
NK cell
NK-cell
outcome
Patient
peptide
Peripheral blood
plasmablasts
progression
proportion
protein level
provide
responsible
SARS-CoV-2
severe patients
severity
severity of COVID-19
target
therapeutic intervention
[DOI] 10.1002/eji.202048858 PMC 바로가기 [Article Type] Article
[DOI] 10.1002/eji.202048858 PMC 바로가기 [Article Type] Article
Case Report: Severe Complement-Mediated Thrombotic Microangiopathy in IgG4-Related Disease Secondary to Anti-Factor H IgG4 Autoantibodies
Immunology
[키워드] amplification
Analysis
analyzed
anti-factor H auto-antibodies
antibodies
assays
Atypical hemolytic uremic syndrome
auto-antibody
autoantibodies
autoantibody
Case report
CFH
complement
Complement C3
Complement factor H
complement factor H-related protein
Corticosteroids
Cyclophosphamide
Deletion
deletions
diagnosed
disease
disorders
ELISA
ENhance
Exome
Human
IgA
IgG
IgG4
IgG4-related disease
Immunoglobulin
implicated
inhibitory
isotype
Meningitis
microangiopathy
multiplex
objective
pathogenic
Patient
performed
predisposition
presenting
probe
Remission
Result
retrospective
SARS CoV2
SARS-CoV-2 pneumonia
secondary antibody
secondary to
Sequencing
susceptibility
System
the patient
thrombotic
thrombotic microangiopathy
[DOI] 10.3389/fimmu.2020.604759 PMC 바로가기 [Article Type] Immunology
[DOI] 10.3389/fimmu.2020.604759 PMC 바로가기 [Article Type] Immunology