The hepatitis E virus ORF1 hypervariable region confers partial cyclophilin dependencyRNA Viruses Published on 2023-11-092024-09-05 Journal: Avicenna Journal of Medical Biotechnology [Category] update2024, [키워드] cyclosporine HEV replication complex replicon [DOI] 10.1099/jgv.0.001919 PMC 바로가기 [Article Type] RNA Viruses
Management and Outcome of COVID-19 Infection Using Nirmatrelvir/Ritonavir in Kidney Transplant PatientsTransplantation Published on 2023-07-262024-09-05 Journal: Clinical journal of the American Society of Nephro [Category] update2024, [키워드] COVID-19 cyclosporine Kidney transplantation Nirmatrelvir/ritonavir tacrolimus [DOI] 10.2215/CJN.0000000000000186 PMC 바로가기 [Article Type] Transplantation
Clinical characteristics and prognosis of patients with idiopathic membranous nephropathy with kidney tubulointerstitial damagearticle Published on 2023-04-262024-09-02 Journal: Renal failure [Category] 대상포진, [키워드] Cyclophosphamide cyclosporine Idiopathic membranous nephropathy tacrolimus tubulointerstitial injury [DOI] 10.1080/0886022X.2023.2205951 PMC 바로가기 [Article Type] article
Differential gene expression profiling reveals potential biomarkers and pharmacological compounds against SARS-CoV-2: Insights from machine learning and bioinformatics approachesArticle Published on 2022-08-172022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 치료기술, 치료제, [키워드] acid approach bioinformatics caused Comorbidities complex interplay Compound contribute coronavirus 2 COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 progression Critical cyclosporine DEGs detect develop differentially expressed gene disease disease pathogenesis dysregulated E2F1 effort EGR1 expressed Factor functional functional enrichment Gene expression profiling Gene regulatory networks Genetic Genomics healthy controls healthy individual humans identify indicated individual individuals insight inter-individual Interaction machine learning approach MAX Mental mental retardation miRNA expression miRNAs nasopharyngeal network analysis offer Ontology overexpressed pandemic pathophysiology pathway pharmacological Potential biomarker Regulatory respiratory responsible reveal RNA-Seq RNA-seq data SARS-CoV-2 SARS-COV-2 infection Spread SRF TFS the SARS-CoV-2 therapeutic option therapeutic target therapeutic targets Vaccine Variability with COVID-19 YY1 [DOI] 10.3389/fimmu.2022.918692 PMC 바로가기
Entry inhibition of hepatitis B virus using cyclosporin O derivatives with peptoid side chain incorporationArticle Published on 2022-08-152023-06-12 Journal: Bioorganic & Medicinal Chemistry [Category] B형 간염, [키워드] cyclic peptides cyclosporine Entry inhibitor Hepatitis B virus Macrocycles membrane permeability Peptoid. [DOI] 10.1016/j.bmc.2022.116862
Pure red cell aplasia accompanied by COVID-19 successfully treated using cyclosporineCase Reports Published on 2022-02-012023-07-07 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), [키워드] COVID-19 cyclosporine Pure red cell aplasia. [DOI] 10.1016/j.jiac.2021.10.018 PMC 바로가기 [Article Type] Case Reports
Dealing with Corticosteroid and High-Dose Cyclosporine Therapy in a Pyoderma Gangrenosum Patient Contracting a COVID-19 InfectionCase Report Published on 2022-01-272022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] autoinflammatory disease combination therapy Contracting Corticosteroids COVID-19 COVID-19 pandemic cyclosporine diagnosed disorders dosage effective High-dose Immunosuppression immunosuppressive immunosuppressive therapy infected with COVID-19 Infection Inflammation initial Methylprednisolone neutrophil Patient physician pyoderma Pyoderma gangrenosum the patient therapeutic strategy Treatment wound healing [DOI] 10.3390/jpm12020173 PMC 바로가기 [Article Type] Case Report
Cyclosporine A Inhibits Viral Infection and Release as Well as Cytokine Production in Lung Cells by Three SARS-CoV-2 VariantsCyclosporine A는 3가지 SARS-CoV-2 변이체에 의한 폐 세포의 바이러스 감염 및 방출 및 사이토카인 생성을 억제합니다Research Article Published on 2022-01-052022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Anti-inflammatory anti-inflammatory drug anti-SARS-CoV-2 vaccines Antibody neutralization Antiviral antiviral activity approach approved B.1.1.7 benefit Betacoronavirus Betacoronavirus genus Calu3 CaLu3 cells Cell cellular mechanism cellular mechanisms coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patients CsA cyclophilin cyclophilin A cyclosporine cyclosporine A cytokine cytokine release Cytokine storm Cytokines dampen death in COVID-19 decrease diffusion disease severity drug Effect Effectiveness exposure to expression Hyperactivation IL-6 IL-8 immune system infected cells Infection interleukin involved knock lung cell lung cells organ P.1 pandemic Patient patients Production progeny virion progeny virions Protein protocol rationale reduce reduce mortality Release released repositioning repurposing respiratory responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants severe COVID-19 patients severe symptom severe symptoms tested therapeutic These data TNF-α transmissible variants treat Treatment variants Viral viral infection Viral RNA viral strain viral strains well [DOI] 10.1128/spectrum.01504-21 PMC 바로가기 [Article Type] Research Article
Medicines for Malaria Venture COVID Box: a source for repurposing drugs with antifungal activity against human pathogenic fungi말라리아 벤처 코비드 박스를위한 의약품 : 인간 병원성 곰팡이에 대한 항진균 활동을 가진 약물을 용도의 소스Research Article Published on 2021-11-082022-08-31 Journal: Memórias do Instituto Oswaldo Cruz [Category] MERS, SARS, 말라리아, 신약개발, 치료제, [키워드] affected Antibiotics antifungal activity antimalarial antitumor agent antitumor agents Antiviral Box caused cells Concentration COVID COVID Box Cryptococcus neoforman Cryptococcus neoformans cycloheximide cyclosporine drug Drug repurposing effective therapy evaluated fungal fungal infections fungi fungicidal fungicidal activity fungistatic Fusarium genetic disorder growth highlight Histoplasma Histoplasma capsulatum Immunosuppressant immunosuppressants impair inhibited malaria Medicine Medicines morphological change morphological changes morphology MOST Mycoses nervous system niclosamide not affected Paracoccidioides brasiliensis pathogenic pathogenic fungi Side effects tested treat [DOI] 10.1590/0074-02760210207 PMC 바로가기 [Article Type] Research Article
Old and New Calcineurin Inhibitors in Lupus NephritisReview Published on 2021-10-212024-09-02 Journal: Journal of Clinical Medicine [Category] 대상포진, [키워드] calcineurin inhibitors cyclosporine lupus nephritis Proteinuria tacrolimus voclosporin [DOI] 10.3390/jcm10214832 PMC 바로가기 [Article Type] Review