Is diabetes a real susceptibility for SARS-CoV-2 oral manifestation?Original Article Published on 2023-12-202024-09-05 Journal: Cryobiology [Category] update2024, [키워드] diabetic patients ELISA furin Saliva [DOI] 10.4103/jomfp.jomfp_208_23 PMC 바로가기 [Article Type] Original Article
Investigation of Risk Factors for Hospitalization of COVID-19 Patients with Diabetes in Najaf, IraqArticle Published on 2022-10-312023-07-11 Journal: Archives of Razi Institute [Category] COVID19(2023년), [키워드] COVID-19 diabetic patients Risk factors [DOI] 10.22092/ARI.2022.357995.2133 PMC 바로가기
A randomised, double-blind, placebo-controlled, multicentre clinical trial of AZD1656 in diabetic patients hospitalised with COVID-19: The ARCADIA Trial – implications for therapeutic immune modulationResearch article Published on 2022-08-182022-10-05 Journal: EClinicalMedicine [Category] 바이오마커, 변종, 임상, [키워드] 1:1 Activation Adaptive immune response addition adverse event ARCADIA assigned AZD1656 Clinical improvement clinical trial Complete COVID-19 cytokine Czech Republic Day death decrease diabetes diabetic patient diabetic patients dose double-blind duration of hospitalisation Efficacy Excalibur False positive finding Full Analysis Set funding Glucokinase activator group homeostatic hospital hospital discharge hospitalised identify immune Immune cell immune modulation immune response Immunochemistry immunomodulatory effect Immunophenotyping implication indicated Innovation investigated involved less Medicine multicentre nine no difference Patient phase Phase 2 Placebo placebo-controlled placebo-controlled clinical trial primary analysis primary endpoint pro-inflammatory randomised Randomly receive recruited reduction in Registered regulatory T cells required risk Romania SARS-CoV-2 screened statistically significant difference suggested Tablet the placebo group therapeutic therapeutic effect treated Treatment treatment allocation Tregs Trial usual care with COVID-19 [DOI] 10.1016/j.eclinm.2022.101604 [Article Type] Research article
SARS-CoV-2 infection impairs the insulin/IGF signaling pathway in the lung, liver, adipose tissue, and pancreatic cells via IRF1SARS-CoV-2 감염은 IRF1을 통해 폐, 간, 지방 조직 및 췌장 세포의 인슐린/IGF 신호 전달 경로를 손상시킵니다Article Published on 2022-08-012022-09-11 Journal: Metabolism: clinical and experimental [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Activation adeno-associated virus adipose Adipose tissue AKT ameliorated analyzed association Autopsy Calu3 Calu3 cell CaLu3 cells Cell cell survival cells condition contribute COVID-19 COVID-19 pathology COVID-19 patient COVID-19 patients COVID-19 severity Critical critical patient critical patients cytokine determine Dexamethasone diabetes Diabetic diabetic patients Dihydrotestosterone Endocrine energy metabolism European population evaluate Evidence exacerbated exhibited Gain Gene Expression Genes GFP HEK293T Hospitalized Host human ACE2 human cells hyperglycemia impair impairment infected with SARS-CoV-2 insulin insulin resistance Insulin signaling Insulin/IGF signaling pathway interferon regulatory factor Interferone intron IRF1 liver lung Lungs male Male sex MAPK metabolic metabolic abnormalities Metabolic abnormality metabolism mouse model mTOR Multiorgan dysfunction Multiple organ damage Non-COVID-19 Non-COVID-19 patients obese obesity Older Older age Organoid overexpressing pancreatic Pancreatic cell pancreatic islets pathology patients patients with COVID-19 PI3K potential mechanism Prevalence provide Regulation reported Repository risk factor Risk factors SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-COV-2 infection serotype severe COVID-19 severity Signaling signaling pathway significantly stem cell survival tissue tissue damage Tissue damage. tissues Transcriptome transcriptome dataset transcriptome datasets Transgenic mouse variant Whole blood whole blood transcriptome with COVID-19 [DOI] 10.1016/j.metabol.2022.155236 PMC 바로가기 [Article Type] Article
A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells당뇨병 환경은 인간 신장 오르가노이드 및 환자 세포에서 SARS-CoV-2 감염에 대한 ACE2 발현 및 세포 감수성을 증가시킵니다Article Published on 2022-06-072022-09-11 Journal: Cell Metabolism [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] ACE2 ACE2 expression aerobic aerobic glycolysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 biopsy Cell cells cellular condition COVID-19 COVID-19 pathogenesis Critical develop diabete diabetes diabetes 2 Diabetic diabetic kidney diabetic patient diabetic patients dichloroacetate door energy metabolism enzyme exhibited Glycolysis hallmark human kidney human kidney organoids. increase individual inhibitor Intervention kidney Kidney disease kidney organoid kidney organoids metabolism mitochondrial Organoid organoids Patient prevented programming reduced resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections severe COVID-19 susceptibility Viral detection Viral load [DOI] 10.1016/j.cmet.2022.04.009 PMC 바로가기 [Article Type] Article
Genotype-phenotype correlation identified a novel SARS-CoV-2 variant possibly linked to severe disease유전형-표현형 상관관계가 심각한 질병과 관련될 수 있는 새로운 SARS-CoV-2 변이를 확인했습니다Article Published on 2022-03-012022-09-11 Journal: Transboundary and emerging diseases [Category] MERS, SARS, 변종, 진단, [키워드] Adults age analysed Asia carried Clinical data Cluster Clustering conditions correlation COVID-19 COVID-19 patient D614G mutation database Diabetic diabetic patient diabetic patients disease severity Dubai Europe European Evidence First wave Fisher Fisher's exact test genomes geographic location Health healthy heterogeneous higher infectivity highlight hospital Hospital admission Hospitalized ICU independent India intensive care Iran laboratory-confirmed majority medical record medical records Mild Missense moderate disease molecular Molecular epidemiology molecular phylogeny Mortality Mutation N proteins Nasopharyngeal swab nasopharyngeal swab PCR nasopharyngeal swabs obese Older age outbreak overweight overweight/obese Patient positive Q271R SARS-CoV-2 SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences SARS-CoV-2 variant selected sequenced Sequencing sequencing data severe COVID-19 severe disease Sex significantly strain synonymous Test Transmission unique United Arab Emirates Viral viral strain viral strains whole genome Whole genome sequencing women [DOI] 10.1111/tbed.14004 PMC 바로가기 [Article Type] Article
Association Between Anti-diabetic Agents and Clinical Outcomes of COVID-19 in Patients with Diabetes: A Systematic Review and Meta-AnalysisResearch article Published on 2022-02-012022-10-05 Journal: Archives of medical research [Category] COVID19(2023년), SARS, 신약개발, [키워드] 95% CI agent Anti-diabetic agents anti-inflammatory effect calculated Characteristics clinical COVID-19 COVID-19 in patient database diabetes diabetic patient diabetic patients DPP-4 inhibitors COVID-19 Effect Effects evaluate Evidence infected with SARS-CoV-2 inhibitor inhibitors Limited lower mortality Meta-analysis metformin Mortality outcome pandemic Patient patients with diabete quantitative synthesis RCT Registration remained Result retrospective review searched Significance statistically statistically significant was performed with COVID-19 [DOI] 10.1016/j.arcmed.2021.08.002 [Article Type] Research article
Does Oxidative Stress Management Help Alleviation of COVID-19 Symptoms in Patients Experiencing Diabetes?Review Published on 2022-01-132022-10-31 Journal: Nutrients [Category] COVID-19, SARS, [키워드] ACE-2 acute respiratory syndrome alleviation angiotensin-converting enzyme 2 antioxidant binding blood vessels cause clinical trial Comorbidities Comorbidity COVID-19 COVID-19 symptoms death diabete diabetes Diabetes Mellitus Diabetic diabetic patients Disease progression effective end-stage renal failure explain help hyperglycemia in silico indicated inflammatory pathway inhibiting interact kidney damage membrane NADPH nephropathy nicotinamide adenine dinucleotide novel coronavirus disease oxidative damage oxidative stress Patient phosphate Prevent PROTECT renal SARS-CoV-2 severe complication therapy Vascular virus [DOI] 10.3390/nu14020321 PMC 바로가기 [Article Type] Review
Metabolic Signatures of Type 2 Diabetes Mellitus and Hypertension in COVID-19 Patients With Different Disease SeverityMedicine Published on 2022-01-102022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] association change characterized COVID-19 COVID-19 disease severity COVID-19 patient COVID-19 severity diabete Diabetes Mellitus Diabetic diabetic patient diabetic patients diagnostic disease severity docosahexaenoic acid docosapentaenoic acid exhibiting Fatty acid FDR Functional enrichment analysis hypertension hypertensive patient hypertensive patients identify Increased metabolic metabolic pathway metabolomics oleic acid palmitic acid pathway Patient patients with diabete Polyunsaturated reduced serum sample severe COVID-19 signature significant changes in Tandem mass spectrometry therapeutic targets triacylglycerol triacylglycerols Type type 2 diabete unsaturated was performed [DOI] 10.3389/fmed.2021.788687 PMC 바로가기 [Article Type] Medicine
Strategies to minimize heterogeneity and optimize clinical trials in Acute Respiratory Distress Syndrome (ARDS): Insights from mathematical modelling급성 호흡 곤란 증후군(ARDS)에서 이질성을 최소화하고 임상 시험을 최적화하기 위한 전략: 수학적 모델링의 통찰력Article Published on 2022-01-012022-09-11 Journal: EBioMedicine [Category] 임상, [키워드] Action angiotensin approval baseline biologic Biomarker Biomarkers center Characteristics clinical response clinical responses clinical trial clinically Clustering complex interaction Corticosteroids COVID-19 Critical Critical care Critical illness Curie determined by Diabetic diabetic patients disease severity disparate driven by example expression foundation heterogeneity heterogeneity of treatment effect hyperinflamed hyperinflamed patient hyperinflamed patients identify IL6 immune response immunomodulation immunomodulatory Immunomodulatory therapies Immunosuppression individual Infection initiated Injury insight manuscript marker Mathematical modelling Microthrombosis Model modelling modulating neutrophil neutrophil recruitment NMF non-negative matrix factorization obese Older older patients outcome parameter Patient predict predicted Predictive Principal component principal component analysis RAS reduction Renin renin-angiotensin system representing Research respiratory respond responsible Strategy supported System System biology systemic cytokine Systems biology the disease therapy Treatment treatment initiation trials Trust [DOI] 10.1016/j.ebiom.2021.103809 PMC 바로가기 [Article Type] Article