Transcriptome profiles of organ tissues from pigs experimentally infected with African swine fever virus in early phase of infectionResearch Article Published on 2024-06-072024-09-05 Journal: Emerging Microbes & Infections [Category] update2024, [키워드] African swine fever differentially expressed gene immune response organ tissue tropism Transcriptome [DOI] 10.1080/22221751.2024.2366406 PMC 바로가기 [Article Type] Research Article
Identification of the Hub Genes and the Signaling Pathways in Human iPSC-Cardiomyocytes Infected by SARS-CoV-2Article Published on 2022-12-012022-11-16 Journal: Biochemical Genetics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis applied Bioinformatics analysis biological process Biomarker Brain caused component Cytoscape software database dataset DEGs differentially expressed gene direct infection down-regulated gene enrichment analysis function Gene Expression Omnibus gene expression profile Gene ontology Genes GEO GraphPad Prism software High-throughput sequencing hub genes Human Human iPSC-cardiomyocytes identification infected with SARS-CoV-2 intestine KEGG kidney Kyoto Ligand liver Lung injury mechanisms myocardial injury organ pathway Pathways PPI PPI network protein-protein interaction R software receptor Research respiratory respiratory symptom SARS-CoV-2 screened sequencing data signaling pathway single-stranded RNA virus statistical analysis statistically significant TNF signaling Type type I interferon up-regulated was obtained was performed website [DOI] 10.1007/s10528-022-10206-7 PMC 바로가기
Environmental pathways affecting gene expression (E.PAGE) as an R package to predict gene-environment associationsArticle Published on 2022-11-042022-11-16 Journal: Scientific Reports [Category] 유전자 메커니즘, [키워드] Abstract affecting articles association biological processe Cell comprehensive resource COVID-19 criteria curated database dataset develop diabetes differentially expressed gene dysregulated enriched biological processes environmental factor environmental factors Gene Expression Gene Expression Omnibus Genes Infection initial Interaction lung cancer pathway predict R package retrieved rheumatoid arthritis selected signature smoking statistical analysis statistically tested [DOI] 10.1038/s41598-022-21988-6 PMC 바로가기
Humoral immunity and transcriptome differences of COVID-19 inactivated vacciane and protein subunit vaccine as third booster dose in humanArticle Published on 2022-10-212022-11-16 Journal: Frontiers in Immunology [Category] 변종, 유전자 메커니즘, [키워드] analyzed antibody approach booster booster dose caused correlation COVID-19 differentially expressed gene dose effective Effectiveness Efficacy Factor Health help Heterologous homologous humoral humoral immune response Humoral immunity immune Immune escape immune response Immunity immunization inactivated Inactivated vaccine indicated innate immune function innate immune pathways participant Perspective Prevalence protein subunit vaccine provided significantly Support System third booster vaccine transcriptional response Transcriptome transcriptome analysis transcriptomic analysis vaccination Vaccine variants of concern VOCs with COVID-19 [DOI] 10.3389/fimmu.2022.1027180 PMC 바로가기
Development of Single-Cell Transcriptomics and Its Application in COVID-19Article Published on 2022-10-162022-11-16 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory distress acute respiratory syndrome application ARDS asymptomatic infection basic reproduction number caused claimed clinical manifestation clinical manifestations component coronavirus coronavirus disease COVID-19 COVID-19 diagnosis COVID-19 research Critical death development differentially expressed gene examined Health immune immune response IMPROVE individual cells mutate offered over physiological resulting SARS-CoV-2 Sequencing single-cell Single-cell transcriptomics syndrome transcriptomics Treatment variety [DOI] 10.3390/v14102271 PMC 바로가기
Highly perturbed genes and hub genes associated with type 2 diabetes in different tissues of adult humans: a bioinformatics analytic workflowArticle Published on 2022-10-012022-11-16 Journal: Functional & integrative genomics [Category] meta-analysis, [키워드] Analysis Apoptosis applied approach association bioinformatics cell type complex defined diabete diabetes Differential gene expression differentially expressed gene downregulated downstream analysis eligible etiology FIVE Gene Expression Gene Expression Omnibus Genes Genetic greater Highly perturbed genes hub gene hub genes identify insulin Kyoto Manifestations marker gene Meta-analysis metabolomics Microarray non-specific ontologies Pathogenesis pathophysiological pathway Pathways Perturbation profiles provided random effect significantly systematic review T2D tissue Type type 2 diabete type 2 diabetes upregulated utility [DOI] 10.1007/s10142-022-00881-5 PMC 바로가기
Projection in genomic analysis: A theoretical basis to rationalize tensor decomposition and principal component analysis as feature selection toolsArticle Published on 2022-09-292022-11-16 Journal: PLoS ONE [Category] 유전자 메커니즘, [키워드] addition adjusted applied Biomarker Cancer Cluster Conventional COVID-19 Critical data set data sets described differentially expressed gene distribution Drug discovery gaussian distribution Genes genomic identifying kidney null hypothesis P-value PCA principal component analysis projection pursuit Sample size statistical statistical test Tensor These data threshold treated vector [DOI] 10.1371/journal.pone.0275472 PMC 바로가기
A Bioinformatic Approach Based on Systems Biology to Determine the Effects of SARS-CoV-2 Infection in Patients with Hypertrophic CardiomyopathyArticle Published on 2022-09-272022-11-15 Journal: Computational and Mathematical Methods in Medicine [Category] SARS, 바이오마커, [키워드] acute respiratory syndrome Affect Analysis Bioinformatic Biology Biomarker Cardiomyopathy cardiovascular system Combination conducted coronavirus coronavirus disease COVID-19 COVID-19 progression datasets DEGs differentially expressed gene disorder drug drug candidates Effect functional Gene Expression Omnibus Genes Genetic GSE147507 identify individual knowledge Lungs microRNA mortality rate; ontology terms other organs patients with COVID-19 protein-protein interaction Proteins Research RNA SARS-CoV-2 Sequencing shared pathway shown statistical Support System therapy transcription factors transcriptomic while [DOI] 10.1155/2022/5337380 PMC 바로가기
Mouse models of COVID-19 recapitulate inflammatory pathways rather than gene expressionArticle Published on 2022-09-262022-11-16 Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, [키워드] ACE2 Analysis approach bioinformatics Concordance COVID-19 debatable differentially expressed gene expressed expression Gene Expression hACE2 Human immune signature Immunity immunopathology inflammatory pathway K18-hACE2 lung damage Lungs mice mouse model orthologue overlap promoter SARS-CoV-2 single copy transcriptional profile transcriptional response Treatment Viral load virus wild-type [DOI] 10.1371/journal.ppat.1010867 PMC 바로가기
Bioinformatics and systems-biology analysis to determine the effects of Coronavirus disease 2019 on patients with allergic asthmaArticle Published on 2022-09-232022-11-15 Journal: Frontiers in Immunology [Category] 바이오마커, 유전자 메커니즘, [키워드] addition allergic Allergic asthma Analysis approach association Asthma asthmatic bioinformatics Biomarker can be used candidate drug candidate drugs Comorbidity conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression COVID-19 symptom Critical dataset datasets DEGs determine differentially expressed gene disease disease biomarker drug Effect elevated Evidence expression level Gene ontology Genes health systems hub gene identify IL-13 IL-5 Increasing Interaction interactions lung mechanism molecular molecular mechanism MUC5AC murine murine model pandemic pathway Pathway analysis Patient patients with COVID-19 phenotype potential molecular risk factor severity shared pathways statistical Systems biology systems-biology. Transcription [DOI] 10.3389/fimmu.2022.988479 PMC 바로가기