Fatal Form of COVID-19 in a Young Male Bodybuilder Anabolic Steroid Using: The First Autopsied CaseArticle Published on 2022-09-292022-11-15 Journal: Medicina [Category] SARS, 진단, [키워드] ACE-2 receptor anabolic anabolic androgenic steroids androgenic steroid atherosclerotic plaques Autopsy COVID-19 death Diffuse alveolar damage Endothelitis form Genetic Genetic predisposition histopathological HLA allele immune system Infection kidneys liver lung male microthrombi Myocardial infarction Myocardium organs pancreas Patient positive Pulmonary edema risk risk factor SARS-CoV-2 SARS-CoV-2 RT-PCR test spleen steroid Testosterone. Thromboembolism tissue [DOI] 10.3390/medicina58101373 PMC 바로가기
Heme oxygenase-1 as an important predictor of the severity of COVID-19코로나19 중증도의 중요한 예측 인자로서의 헴 옥시게나제-1Article Published on 2022-08-242022-09-11 Journal: PLoS ONE [Category] 바이오마커, [키워드] activated Activation addition Admission alveolar damage Anti-inflammatory anti-oxidative AUC Biomarker C-reactive protein caused CD163 Chest computed tomography clinical parameter Computed tomography Concentration consolidation correlated COVID-19 COVID-19 patient COVID-19 patients Critical cytokine Cytokine storm Diffuse alveolar damage disease severity evaluated GGO Ground glass opacity heme ICU admission inflammatory cells investigated Lactate lactate dehydrogenase lung Lungs Macrophage macrophage phenotype marker Mild moderate occur on admission outcome oxidative stress parameter Pathogenesis pathogenesis of COVID-19 Predictive pro-inflammatory macrophage phenotype produced Protein serum serum concentrations serum lactate severe cases severity severity of COVID-19 therapeutic target were assessed were measured [DOI] 10.1371/journal.pone.0273500 PMC 바로가기 [Article Type] Article
Diffuse alveolar damage patterns reflect the immunological and molecular heterogeneity in fatal COVID-19Research article Published on 2022-08-242022-10-05 Journal: EBioMedicine [Category] SARS, 진단, 치료기술, [키워드] alveolar damage analysis Autopsy Bacteria Candida parapsilosis CD8+ T cells CD8+T cells Cell changes in complex correlated COVID-19 COVID-19 case COVID-19 patients DAD diffuse Diffuse alveolar damage disease eight elevated enriched pathway exhibit Extracellular matrix Factor fatal COVID-19 feature fibroblasts finding foundation funding fungi heart heterogeneity histological humoral immune immune cells immunohistochemistry immunological immunopathology implication innate immune response Lung disease lung tissue Lungs Macrophage macrophages management Melinda Gate modulate molecular multiplex occur Patient performed progression quantified Regeneron Pharmaceuticals response SARS-CoV-2 Secondary infection subsequent Support Swedish the disease Transcriptome Treatment strategies [DOI] 10.1016/j.ebiom.2022.104229 [Article Type] Research article
Host and microbiome features of secondary infections in lethal covid-19Research article Published on 2022-08-132022-10-05 Journal: iScience [Category] 바이오마커, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] alteration Bacterial C1q cause cellular complement contribute Control DAD death Defense Diffuse alveolar damage dominant driving Factor feature fungal pathogen highlight Immunity immunology inhibitory lethal lung lung tissue Macrophage microbial Microbiome Mortality myeloid cells organ pandemic pathology pathophysiological reduced RNA-Seq SARS-COV-2 infection Secondary infection secondary infections significantly stratified subgroup Virology [DOI] 10.1016/j.isci.2022.104926 [Article Type] Research article
Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies?COVID-19의 장기 발현: 부검을 통해 지금까지 (뿐만 아니라) 무엇을 배웠습니까?Review Published on 2022-08-012022-09-11 Journal: Virchows Archiv [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Acute kidney damage alveolar alveolar damage analytical methods Antithrombotic applicability Autopsies Autopsy cells change characterized clinical Combination conditions COVID-19 COVID-19 pandemic declining diffuse Diffuse alveolar damage direct infection disease Endothelial dysfunction explained immune response International Intussusceptive angiogenesis kidney limitation majority manifestation mechanism mechanisms morphological feature morphological features National nonspecific open organ organ injury organs pathological change pathological changes pathologist pathophysiology question recommendation Research SARS-CoV-2 SARS-CoV-2. supported thrombosis tissue tissue tropism tissues Treatment turn variants variants of concern vascular inflammation vasoconstriction [DOI] 10.1007/s00428-022-03319-2 PMC 바로가기 [Article Type] Review
Pulmonary Parenchymal Changes in COVID-19 SurvivorsObservational Study Published on 2022-07-012022-10-05 Journal: The Annals of thoracic surgery [Category] 임상, [키워드] age airways Asymptomatic Autopsy blinded change Control control group COVID-19 COVID-19 diagnosis COVID-19 group COVID-19 infection COVID-19 pandemic determine Diffuse alveolar damage Elective emphysema examined interstitial intra-alveolar lung lung cancer lung damage lung parenchyma lung resection macrophages median moderate multicenter observational study no difference nodule Organizing pneumonia pathologist Patient pulmonary pulmonary damage question specimen survivor Survivors survivorship vasculature was performed [DOI] 10.1016/j.athoracsur.2021.06.076 PMC 바로가기 [Article Type] Observational Study
Histologic pulmonary lesions of SARS-CoV-2 in 4 nonhuman primate species: An institutional comparative reviewReview Published on 2022-07-012023-07-07 Journal: Veterinary pathology [Category] COVID19(2023년), [키워드] animal models coronavirus COVID-19 Diffuse alveolar damage nonhuman primates SARS-CoV-2 zoonoses. [DOI] 10.1177/03009858211067468 PMC 바로가기 [Article Type] Review
Hamster models of COVID-19 pneumonia reviewed: How human can they be?COVID-19 폐렴의 햄스터 모델 검토: 어떻게 인간이 될 수 있습니까?Review Published on 2022-07-012022-09-11 Journal: Veterinary pathology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age alveolar damage animal model characteristic clinically Coagulopathy condition consequence coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 diagnostic Diffuse alveolar damage examined facilitate feature hamster hamsters Histopathology Human human disease humans immune function immune functions Infection Inference Inflammation information limit manifestation Mesocricetus mice moderate molecular outcome pandemic pathology pathway Patient Phodopus Pneumonia Preclinical research Research respiratory respiratory tract review rodents SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 similarity Still susceptible susceptible patient the disease therapy Vaccines Vaccines. variants of concern Vascular virus [DOI] 10.1177/03009858211057197 PMC 바로가기 [Article Type] Review
A new mouse unilateral model of diffuse alveolar damage of the lungArticle Published on 2022-06-012023-07-08 Journal: Inflammation research : official journal of the Eu [Category] COVID19(2023년), [키워드] acute respiratory distress syndrome COVID-19 Diffuse alveolar damage lung mouse model. [DOI] 10.1007/s00011-022-01568-0 PMC 바로가기
Ultrastructural examination of lung “cryobiopsies” from a series of fatal COVID-19 cases hardly revealed infected cells일련의 치명적인 COVID-19 사례에서 폐 "냉동생검"의 미세구조 검사는 감염된 세포를 거의 드러내지 않음Article Published on 2022-05-012022-09-11 Journal: Virchows Archiv [Category] COVID19(2023년), SARS, 치료기술, [키워드] accumulation aggregates alveolar alveolar damage alveolar epithelium Analysis Autopsy caused Cell cell types cells coronavirus COVID-19 patient COVID-19 patients death Detachment diffuse Diffuse alveolar damage electron electron microscopy Endothelium erythrocytes Extracellular fatal COVID-19 FIBRIN fixation fixed granulocyte Histopathology hyaline membrane hyaline membranes hyperplasia immune impairment IMPROVE infected cell investigated latency leukocyte leukocytes lung lung damage macrophages mechanisms Microscopy neutrophilic Particle Patient Region Replication respiratory distress Respiratory distress syndrome Sample SARS‐CoV‐2 Stage Stress stress response the disease the patient these cell These cells Thin section thrombocyte Thrombocytes tissue Ultrastructural analysis ventilated patient ventilated patients virus Virus particle. [DOI] 10.1007/s00428-022-03308-5 PMC 바로가기 [Article Type] Article