SARS-CoV-2 infection exacerbates the cellular pathology of Parkinson’s disease in human dopaminergic neurons and a mouse modelArticle Published on 2024-05-142024-09-05 Journal: Cell Reports Medicine [Category] update2024, [키워드] COVID-19 sequalae DA neuron disease modeling Dopaminergic neuron hACE2 transgenic mouse Neuroinflammation neurological sequelae Parkinson’s disease PD SARS-CoV-2 [DOI] 10.1016/j.xcrm.2024.101570 PMC 바로가기 [Article Type] Article
Modeling spillover dynamics: understanding emerging pathogens of public health concernArticle Published on 2024-04-292024-09-05 Journal: Scientific Reports [Category] update2024, [키워드] Applied mathematics disease modeling Emerging infectious diseases Infectious diseases spillover [DOI] 10.1038/s41598-024-60661-y PMC 바로가기 [Article Type] Article
Antigenic strain diversity predicts different biogeographic patterns of maintenance and decline of antimalarial drug resistancearticle Published on 2024-02-282024-09-01 Journal: eLife [Category] 말라리아, [키워드] antigenic diversity disease modeling drug resistance Epidemiology global health Greater Mekong Subregion P. falciparum [Article Type] article
Modeling Cardiac SARS-CoV-2 Infection with Human Pluripotent Stem CellsReview Published on 2022-12-012023-07-10 Journal: Current cardiology reports [Category] COVID19(2023년), [키워드] cardiovascular diseases COVID-19 disease modeling IPSC pluripotent stem cells SARS-CoV-2 [DOI] 10.1007/s11886-022-01813-2 PMC 바로가기 [Article Type] Review
Network approaches for modeling the effect of drugs and diseases약물 및 질병의 영향 모델링을 위한 네트워크 접근 방식Review Published on 2022-07-182022-09-11 Journal: Briefings in Bioinformatics [Category] COVID19(2023년), SARS, 신약개발, [키워드] adverse effects Algorithm approach biological networks biological response Chronic diseases Compound computational method Computational methods COVID-19 disease disease modeling Diseases drug drug combination drug combinations drug target drug treatments drug’s MOA drugs explain FDA-approved drug generate IMPROVE in silico induce mechanism mechanism of action network network analysis omics technologies Perturbation perturbations SARS-COV-2 infection SARS-CoV-2 infections Stage study drug Support targets therapeutic effect These data to define Treatment [DOI] 10.1093/bib/bbac229 PMC 바로가기 [Article Type] Review
Mature neutrophils and a NF-κB-to-IFN transition determine the unifying disease recovery dynamics in COVID-19성숙한 호중구와 NF-κB에서 IFN으로의 전환은 COVID-19에서 통합된 질병 회복 역학을 결정합니다Article Published on 2022-06-212022-09-11 Journal: Cell Reports Medicine [Category] 바이오마커, 유전자 메커니즘, [키워드] Blood Cell cell deconvolution cellular cellular and molecular Cellular and molecular mechanisms changes changes in clinically courses COVID-19 decrease determine differentiation disease disease modeling disease recovery Effect framework Gene regulation heterogeneous homeostasis immune immunology implication indication interferon Kinetics mechanisms Medicine neutrophil NF-κB other disease other diseases outcome Patient presenting Regulatory restoration resulting severe COVID-19 Systems biology T cell T cell activation the disease tissues transcriptomes viral infection [DOI] 10.1016/j.xcrm.2022.100652 PMC 바로가기 [Article Type] Article
Projected resurgence of COVID-19 in the United States in July-December 2021 resulting from the increased transmissibility of the Delta variant and faltering vaccination델타 변이형의 전염성 증가와 백신 접종 중단으로 인해 2021년 7월-12월에 미국에서 예상되는 COVID-19의 부활Article Published on 2022-06-212022-09-11 Journal: eLife [Category] COVID19(2023년), SARS, 변종, [키워드] Coverage COVID-19 COVID-19 pandemic Critical death deaths Delta delta variant disease disease modeling Epidemiology expected global health greater highlighting hospitalizations Human Impact impacts Increases increases in magnitude modeling nine occur pandemic predict produced reduced reported resulting risk SARS-CoV-2 scenario scenario projection. spring subset summer the United State The United States Transmissibility Transmission United States vaccination Vaccine variant [DOI] 10.7554/eLife.73584 PMC 바로가기 [Article Type] Article
SARS-CoV-2 transmission dynamics in the urban-rural interfaceArticle Published on 2022-05-012023-07-08 Journal: Public health [Category] COVID19(2023년), [키워드] COVID-19 disease modeling Prevention measures Urban-rural interface. [DOI] 10.1016/j.puhe.2022.02.007 PMC 바로가기
SARS-CoV-2 infects and replicates in photoreceptor and retinal ganglion cells of human retinal organoidsArticle Published on 2022-04-122023-07-08 Journal: Stem Cell Reports [Category] COVID19(2023년), [키워드] COVID-19 cytokine disease modeling inflamation iPSCs photoreceptors Retina Retinal ganglion cells retinal organoids. SARS-CoV-2 [DOI] 10.1016/j.stemcr.2022.02.015 PMC 바로가기
A stochastic process based modular tool-box for simulating COVID-19 infection spreadResearch article Published on 2022-03-052022-10-05 Journal: Informatics in Medicine Unlocked [Category] 치료기술, [키워드] absence affected applied average basic reproduction number can be used comparable coronavirus country COVID-19 COVID-19 infection COVID-19 simulation defined develop disease disease modeling Effect Efficacy Epidemics Factor fraction function geographical area growth infected individuals Infection Infectious disease initial intrinsic Mask maximum-likelihood novel coronavirus disease pandemic parameter performed producing quarantine R language Research Result Spread stages the epidemic the vaccine vaccination Viral virulence [DOI] 10.1016/j.imu.2022.100899 [Article Type] Research article