disease severities – Communicable Diseases Research

Identifying Immunological and Clinical Predictors of COVID-19 Severity and Sequelae by Mathematical Modeling

수학적 모델링을 통한 COVID-19 심각도 및 후유증의 면역학적 및 임상적 예측인자 식별

Article

Published on 2022-04-202022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단,

Bacterial microbiota in upper respiratory tract of COVID-19 and influenza patients

COVID-19 및 인플루엔자 환자의 상기도 내 세균성 미생물총

Observational Study

Published on 2022-03-012022-09-11
Journal: Experimental Biology and Medicine [Category] 유전자 메커니즘, 임상,

[키워드] 16S rDNA alteration Bacteria Bacterial Bacterial infections Bacterial microbiota Community COVID-19 COVID-19 group COVID-19 patient COVID-19 patients disease severities Enterobacteriaceae Fusobacterium group groups High-throughput sequencing Influenza knowledge mechanism Microbial communities microbial community microbiota MiSeq mucosal surface not significantly different Pathogens Patient patients patients with influenza platform predominant Prevotella profile provide Pseudomona Pseudomonas rDNA Respiratory disease respiratory viral infection respiratory viral infections Secondary bacterial infections Secondary infection secondary infections Sequencing significantly significantly lower Staphylococcus Streptococcus susceptibility upper respiratory upper respiratory tract viral infections viral infectious diseases
[DOI] 10.1177/15353702211057473 PMC 바로가기 [Article Type] Observational Study

Changes in Serum Neutralizing Antibodies Levels During Convalescence of COVID-19 Patients

Medicine

Published on 2022-02-112022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

Anti-prothrombin autoantibodies enriched after infection with SARS-CoV-2 and influenced by strength of antibody response against SARS-CoV-2 proteins

Research Article

Published on 2021-12-032022-10-29
Journal: PLoS Pathogens [Category] COVID-19, SARS,

[키워드] abnormality Affect Analysis anti-SARS-CoV-2 antibody antibody response against antiphospholipid antibody association assumed autoantibody Autoimmune disease automated Blood Blood donors Coagulation Cohort coronavirus 2 criteria described detrimental develop disease severities disease severity displaying elements elicited evidenced heterogeneity hyperinflammation IgG antibody IgM IgM and IgG IgM antibody immune response immunoassay immunoreactivity independent risk factor individual individuals Infection infection with SARS-CoV-2 infections investigated linear lupus anticoagulant mixed-effects model morbidity non-infected organ systems pathogenicity Patient patients with SARS-CoV-2 phospholipid Pregnancy proportion Protective Proteins Research respiratory responsible SARS-CoV-2 SARS-CoV-2 disease SARS-CoV-2 protein SARS-CoV-2 proteins selected severity Sex shown Symptom syndrome the antibody response thought thrombosis triggered vascular thrombosis while
[DOI] 10.1371/journal.ppat.1010118 PMC 바로가기 [Article Type] Research Article

An epigenome-wide DNA methylation study of patients with COVID-19

COVID-19 환자의 후성유전체 DNA 메틸화 연구

Article

Published on 2021-11-012022-09-11
Journal: Annals of human genetics [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 진단,

[키워드] Above analyses Analysis biological processes can be used CHN2 CHST15 conducted COVID-19 COVID-19 patient COVID-19 patients CPLX2 CRHR2 DCAKD disease severities DNA DNA methylation downregulated duplicates eliminating EpiC Epigenetic epigenetic regulation expression function functions Genes GNAI2 GNAS GNG7 healthy subject healthy subjects HECW1 highest highly pathogenic hub genes HYAL1 Illness severity Illumina immune system investigated methylated MIR510 molecular mechanism molecular mechanisms pathophysiology pathway Pathways patients with COVID-19 PDE11A PPI PRKAG2 PRKCZ progression promoter region public health Regulation SARS-CoV-2 SARS-COV-2 infection selected Sequencing severe group Signal transduction SMG6 were used
[DOI] 10.1111/ahg.12440 PMC 바로가기 [Article Type] Article

Functional Activity of the Complement System in Hospitalized COVID-19 Patients: A Prospective Cohort Study

Observational Study

Published on 2021-10-282022-10-04
Journal: Frontiers in Immunology [Category] MERS, SARS, 임상,

[키워드] 95% CI Activation activity acute lung injury acute phase Admission Alternative pathway Analysis autopsy studies C1 esterase inhibitor collected complement complement system Concentration confounding factors correlated COVID-19 COVID-19 patient Critically ill death Disease progression disease severities disease severity Factor ficolin-3 Follow-up hospitalized COVID-19 patient hospitalized patient ICU admission implicated in vitro in vivo In-hospital death Inflammation Inflammatory marker IQR lectin pathway male mannose-binding lectin mechanical ventilation median multiple comorbidities no significant difference occurred Pathogenesis pathway Patient PCR-confirmed Primary outcome progression Prospective prospective observational study Protein reduced required Result resulting ROC Curve SARS-CoV-2 SARS-COV-2 infection serum sample severe COVID-19 severe disease significantly significantly lower single-center System the patient threshold Ventilation
[DOI] 10.3389/fimmu.2021.765330 PMC 바로가기 [Article Type] Observational Study

Relative expression of proinflammatory molecules in COVID-19 patients who manifested disease severities

질병 중증도를 나타내는 COVID-19 환자에서 전염증 분자의 상대적 발현

Article

Published on 2021-10-012022-09-11
Journal: Journal of medical virology [Category] SARS, 치료기술, 치료제,

[키워드] ACE2 ACE2 expression Activation acute respiratory syndrome acute respiratory syndrome coronavirus 2 Aggressive angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Chain Reaction characterized chemokine chemokines convalescent stage coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 patient COVID-19 patients cytokine cytokine expression Cytokines Day diagnosed disease disease severities disease severity expressed expression expression level expression levels expressions female patient Female patients groups healthy volunteer help IL-12 IL-6 immune response immune system immune systems Inflammatory interleukin investigated leukocyte leukocytes log Macrophage management manifested Mild moderate monocyte monocyte chemotactic protein-1 nasal swab Necrosis nine onset of symptom opposite overexpressed participated Patient patients PCR method performed polymerase chain polymerase chain reaction positive correlation positively correlated post-COVID-19 patient proinflammatory proinflammatory molecule proinflammatory molecules Quantitative RANTES real-time RT-PCR regulated relative relative expression relative expression. RNA secreted semi-quantified severe acute respiratory syndrome Coronavirus severe cases significantly SPSS SPSS 24.0 statistical test Statistical tests T cell the patient therapy TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α upregulated Viral load
[DOI] 10.1002/jmv.27112 PMC 바로가기 [Article Type] Article

On Deep Landscape Exploration of COVID-19 Patients Cells and Severity Markers

COVID-19 환자 세포 및 심각도 마커에 대한 심층적 조사

Immunology

Published on 2021-09-162022-09-11
Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] Analysis analyzed Biomarker Bronchoalveolar lavage fluid Cell cell heterogeneity cell population clinical response clinical responses contribute correlated COVID-19 COVID-19 symptom criterion Critical deep develop disease disease severities disease severity effective Effects epithelial exploration expression Factor healthy controls heterogeneous heterogeneous population high accuracy Immune cell immune cells immune landscape immune memory immune response immune system landscape lung machine-learning mechanism microenvironment moderate nine pathway Pathways Patient patients patients with COVID-19 patients with moderate pro-inflammatory response Prognosis promote regulate Regulatory required researcher response responses RNAseq second Severe patient severe patients severity single-cell single-cell analysis Spectrum the disease the patient Therapeutic strategies transcriptional Viral viral clearance
[DOI] 10.3389/fimmu.2021.705646 PMC 바로가기 [Article Type] Immunology

Comparative performance of SARS-CoV-2 lateral flow antigen tests and association with detection of infectious virus in clinical specimens: a single-centre laboratory evaluation study

SARS-CoV-2 측방유동항원 검사의 비교 성능 및 임상 검체에서 감염성 바이러스 검출과의 연관성: 단일 센터 실험실 평가 연구

Articles

Published on 2021-09-012022-09-10
Journal: The Lancet. Microbe [Category] MERS, SARS, 변종, 치료기술, 치료제,

[키워드] alternative technology Analysis Antigen association B.1.1.7 B.1.1.7 variant be positive cassette clinical sample clinical samples collected Community Comparative comparison Comprehensive copy number cornerstone correlation COVID-19 Ct value Ct values Culture Department Device diagnostic diagnostic test disease severities dominant ENCODE evaluated except for family finding FIVE Fluorescence foundation funding Genotype greater group head Head-to-head comparison health-care help highest household contacts identify implementation infected individual infected individuals infectious sample Infectious virus Inpatient Inpatients King Laboratory Lateral lateral flow LFD limit of detection limitation London Longitudinal studies longitudinal study Medical Research Council naso-oropharyngeal swab not affected Outpatient outpatients PCR PCR cycle PCR testing PFUs plaque-forming unit positive Quantitative quantitative culture question raised ranged Rapid Rapid test real-time RT-PCR reduced RNA RT-rtPCR SARS-CoV-2 SARS-CoV-2 N gene SARS-CoV-2 testing selected sensitivities sensitivity Specificities specificity spring St Thomas' Hospital Support Surescreen Swab swabs Test test result tested Thoma threshold UK variant B.1.1.7 understanding Vero E6 VERO E6 cells Viral viral culture viral growth Viral RNA virus virus culture virus infectivity Wellcome Trust were assessed were used whole-genome sequencing
[DOI] 10.1016/S2666-5247(21)00143-9 PMC 바로가기 [Article Type] Articles

Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients

Netosis 마커 및 습기의 진화는 중환자가 아픈 Covid-19 환자에서 예후 가치가 있습니다.

Article

Published on 2021-08-032022-08-31
Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 진단, 치료기술,

[키워드] (cfDNA) Acute inflammation Cell cfDNA Clinical parameters controls coronavirus coronavirus disease coronavirus disease 19 correlated COVID-19 COVID-19 patient COVID-19 patients Critically ill damage DAMP decrease disease severities disease severity Disease-free survival DNA event Evolution Extracellular GAS6 ICU ICU admission immune Infection intensive care intensive care unit lead lowering lowest marker measure molecular pattern molecular patterns Mortality multi-organ dysfunction NETosis neutrophil neutrophil counts Neutrophil elastase Neutrophils Occurrence parameter parameters Patient patient survival plasma Prognostic value Respiratory failure Respiratory tract diseases scoring system Sepsis severe COVID-19 survival the patient tissue damage Ventilator-free days viral infection weakness
[DOI] 10.1038/s41598-021-95209-x PMC 바로가기 [Article Type] Article