Newly developed type 1 diabetes after coronavirus disease 2019 vaccination: A case report2019년 코로나19 예방접종 후 새롭게 발생하는 제1형 당뇨병: 증례보고Case Reports Published on 2022-06-012022-09-11 Journal: Journal of Diabetes Investigation [Category] 유전자 메커니즘, [키워드] Antigen autoantibodies autoantibody Autoimmune response autoimmune responses Case report coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccination COVID-19 vaccine destruction deteriorate diabete diabetes diagnosed dose DQB1 DRB1 Exacerbation glucagon glycemic control Haplotype haplotypes human leukocyte antigen immunological mechanism insulin Insulin therapy Intensive Japanese leukocyte Moderna positive recipient recipients reported second vaccination stimulation test suggested the patient Type 1 diabetes type 2 diabetes vaccination Vaccine β-cell β-cells [DOI] 10.1111/jdi.13757 PMC 바로가기 [Article Type] Case Reports
HLA-DR polymorphism in SARS-CoV-2 infection and susceptibility to symptomatic COVID-19SARS-CoV-2 감염의 HLA-DR 다형성 및 증상이 있는 COVID-19에 대한 감수성Article Published on 2022-05-012022-09-11 Journal: Immunology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료법, [키워드] age allele analysed Analysis anti-spike antibody antibody association asymptomatic infection Comorbidity COVID COVID-19 death disease dose DRB1 Gender genomic variation Genotype HCW HCWs healthcare worker HLA HLA-DR HLA-DRB1 HLA-DRB1* Host human leukocyte antigen immune response immune responsiveness Immunogenetics imputation include increased risk Infection investigated leukocyte Mild nucleocapsid nucleoprotein outcome PCR polymorphism reason recruited SARS-CoV-2 SARS-COV-2 infection second dose seroconverted severe disease susceptibility Symptom symptomatic symptomatic COVID-19 T-cell T-cell immunity T-cell Response T-cell responses titre Trial registration vaccination Vaccine vaccine doses [DOI] 10.1111/imm.13450 PMC 바로가기 [Article Type] Article
Bioinformatic analyses suggest augmented interleukin-17 signaling as the mechanism of COVID-19-associated herpes zoster생물 정보학 분석은 COVID-19 관련 대상 포진의 메커니즘으로 증강된 인터루킨-17 신호 전달을 제안합니다Article Published on 2021-12-012022-09-11 Journal: Environmental science and pollution research inter [Category] 대상포진, 두창, 수두, 유전자 메커니즘, 홍역, [키워드] Analysis ApoE ARSA Bioinformatic blistering CCR2 CCR5 cell differentiation correlation COVID-19 CRP CXCL13 cytokine cytokine receptor distribution dorsal root ganglia DRB1 EGFR ESR1 Genetic GP2 Herpe herpes zoster herpetic neuralgia HLA-A HLA-B HLA-DRB1 IL-17 IL10 IL17A IL5 IL6 IL7 Increasing indicated Interaction interleukin-17 involved Jak-STAT mechanism pathophysiological mechanism raise raised Rash receptor resulting risk SARS-CoV-2 Signaling STAT STAT3 subset suggested TECTA Th17 THBS1 TNF varicella Varicella zoster virus virus Zoster [DOI] 10.1007/s11356-021-15567-x PMC 바로가기 [Article Type] Article
MHC Variants Associated With Symptomatic Versus Asymptomatic SARS-CoV-2 Infection in Highly Exposed Individuals고도로 노출된 개인의 무증상 SARS-CoV-2 감염 대 무증상 SARS-CoV-2 감염과 관련된 MHC 변이Immunology Published on 2021-09-282022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age allele analyzed antigen-presentation association Asymptomatic Combination comparable contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytotoxic activity develop downregulating DRB1 DRB1*04:01 Epigenetic explained expression Factor Factors followed by Genetic genetic factors Genotype genotypes Haplotype haplotypes histocompatibility complex HLA HLA-A HLA-DRB1 identify immune modulation immune response immunological individual individuals infected individual infected individuals Infection involved low expression major histocompatibility complex MHC MICA MICB modulate natural killer NK cell one individual partner pathway Quantitative remained residue resistance respiratory SARS-CoV-2 seronegative serum severe acute respiratory syndrome Coronavirus susceptibility Symptom symptomatic symptomatic COVID-19 symptomatic infection symptomatic infections uninfected variant variants whole-exome sequencing women [DOI] 10.3389/fimmu.2021.742881 PMC 바로가기 [Article Type] Immunology
Association of HLA genotypes, AB0 blood type and chemokine receptor 5 mutant CD195 with the clinical course of COVID-19HLA 유전자형, AB0 혈액형 및 케모카인 수용체 5 돌연변이 CD195와 COVID-19의 임상 경과와의 연관성Observational Study Published on 2021-09-162022-09-10 Journal: European Journal of Medical Research [Category] 변종, 임상, 진단, [키워드] ABO blood group absence Adaptive immune response addition addressed age Analysis anti-S IgG anti-S IgG levels Antigen antigens antiviral immune response association benefit Blood Blood Group carriers caused CCR5 Chemokine receptor Clinical course clinical courses Cohort Composite courses COVID-19 COVID-19 convalescent patient Cox regression deletion mutant disease disease severity DRB1 exploratory fatal disease Follow-up genetics genotypes Group antigen heterozygous Hierarchical HLA HLA allele HLA alleles HLA class I HLA class I genotypes HLA class II Human human leukocyte antigen humoral immune responses immunogenetic background infection with SARS-CoV-2 investigated leukocyte median Mild Moderate COVID-19 morbidity mutant Mutation Neutralizing antibodies neutralizing capacity observation observational study pandemic disease parameter patient cohort patient population pauci-symptomatic potential risk presence or absence progression prolonged disease Prospective Protective protective effect reduced required Result SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe disease severity significantly supplementary material the patient vaccination response virus was performed [DOI] 10.1186/s40001-021-00560-4 PMC 바로가기 [Article Type] Observational Study
MHC Haplotyping of SARS-CoV-2 Patients: HLA Subtypes Are Not Associated with the Presence and Severity of COVID-19 in the Israeli PopulationSARS-CoV-2 환자의 MHC Haplotyping: HLA 하위 유형은 이스라엘 인구에서 COVID-19의 존재 및 심각성과 관련이 없습니다Article Published on 2021-08-012022-09-11 Journal: Journal of Clinical Immunology [Category] SARS, 변종, 치료기술, [키워드] Ashkenazi association associations conducted COVID-19 COVID-19 incidence COVID-19 severity disease severity Diseases DQB1 DRB1 FIVE Genetic variant Haplotype heterozygosity HLA HLA alleles HLA analysis HLA haplotype HLA haplotypes Hospitalization Hospitalized increased risk individual Infection Israel loci MHC pandemic Patient PCR Population positive Presence reported SARS-CoV-2 SARS-COV-2 infection severity subject subset subtype tested the disease viral infection viral infections with COVID-19 [DOI] 10.1007/s10875-021-01071-x PMC 바로가기 [Article Type] Article
Association between the HLA genotype and the severity of COVID-19 infection among South AsiansHLA 유전자형과 남아시아인의 COVID-19 감염 중증도와의 연관성Article Published on 2021-07-012022-09-12 Journal: Journal of medical virology [Category] MERS, SARS, 진단, [키워드] allele Asia Asian association Bangladeshis blood sample collected COVID-19 COVID-19 infection DNA DQA1 DQB1 DRB1 Effectiveness examined Factor Frequency Genetic Genotype genotyping highlight HLA HLA class II human leukocyte antigen incidence Infection Mild mild infection molecular outcome P-value Pakistanis Patient polymerase chain polymorphism Population Prognosis Regional severity severity of COVID-19 significantly significantly higher South South Asia South Asian statistical the disease Vaccine Variation was performed with COVID-19 [DOI] 10.1002/jmv.27003 PMC 바로가기 [Article Type] Article
Genetic variability in COVID-19-related genes in the Brazilian populationArticle Published on 2021-04-022022-10-04 Journal: Human Genome Variation [Category] 유전자 메커니즘, [키워드] 1000 Genomes Project 1KGP ABO ACE2 ACE2 gene Affect allele frequency Analysis analyzed angiotensin-converting enzyme 2 Brazil Brazilian Brazilians candidate gene CCR9 Clinical prognosis contribute country COVID-19 COVID-19 case COVID-19 infection COVID-19 patients COVID-19 severity CTSL CXCR6 database disease DQB1 DRB1 examined Exome exomes explain FYCO1 gene sequence genetic background genetic study genetic variability Genetic variation Genome gnomAD help highest HLA allele Host host cells human lung cells identify IL6 Immunity implicated individual individual level infect Infection infection with SARS-CoV-2 Influenza virus information International investigated life-threatening loci LZTFL1 nonsynonymous Other Patient Phase 3 Pneumonia Population predicted previous study Protein Rare variants rate of infection recent receptor recorded reported risk SARS-CoV-2 SARS-COV-2 infection Seven shown SLC6A20 suggested susceptibility therapeutic targets TMPRSS2 transmembrane serine protease type I interferon unique university Variability variant Variation viral infection XCR1 [DOI] 10.1038/s41439-021-00146-w PMC 바로가기 [Article Type] Article
Human Leukocyte Antigen Complex and Other Immunogenetic and Clinical Factors Influence Susceptibility or Protection to SARS-CoV-2 Infection and Severity of the Disease Course. The Sardinian Experience인간 백혈구 항원 복합체 및 기타 면역유전학적 및 임상적 요인은 SARS-CoV-2 감염에 대한 감수성 또는 보호 및 질병 경과의 중증도에 영향을 미칩니다. 사르데냐 체험Randomized Controlled Trial Published on 2020-12-042022-08-13 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 임상, 진단, [키워드] 95% CI All participants allele alleles analyzed Asymptomatic asymptomatic or pauci-symptomatic patients Autoimmune disease Autoimmune diseases beta-thalassemia beta-thalassemia trait beta-thalassemic trait Care carried clinical Clinical data Clinical outcome clinical, genetic and immunogenetic factors collected controls Course COVID-19 severity deficiency Demographic and clinical data disease course DRB1 evaluate experience extended haplotype Factor Frequency G6PDH G6PDH deficiency Genetic genetic factor genetic factors Genetic polymorphism Glucose Glucose-6-phosphate glucose-6-phosphate dehydrogenase haplotype frequencies haplotypes health problem healthy HLA allele HLA class I HLA class I and II molecules HLA-A HLA-A*02:05, B*58:01, C*07:01 HLA-A*30:02 HLA-A*30:02, B*14:02, C*08:02 HLA-C HLA-C*04:01 allele HLA-DRB1*08:01 allele home care home care patients hospital hospital care hospitalized patient hospitalized patients Human human leukocyte antigen immunogenetic background immunogenetic factors in-patient infections influence Influenza influenza vaccination Italy Male sex material Mild disease negative influence Older age Other Participants Pathogenesis Patient patients pauci-symptomatic phosphate predisposing factor protection protective effect public health recruited related clinical consequence related clinical consequences required Result Sardinia Sardinian Sardinian control Sardinian population SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patients seasonal flu severe disease Sex susceptibility Taking thalassemia the disease three-loci haplotype vaccination with mild disease without symptoms world-wide public health problem [DOI] 10.3389/fimmu.2020.605688 PMC 바로가기 [Article Type] Randomized Controlled Trial
Expression estimation and eQTL mapping for HLA genes with a personalized pipeline개인화된 파이프라인으로 HLA 유전자에 대한 발현 추정 및 eQTL 매핑Research Article Published on 2019-04-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (Human Leukocyte Antigens abundance adaptive aligned allele antibody applied approach approaches balancing selection biases carried Causality cause choice classical HLA loci dataset datasets develop difficulty disease disease phenotype disease susceptibility Diseases Divergence downstream analyses downstream analysis DPA1 DPB1 DQA1 DQB1 DRB1 eQTL eQTL mapping eQTLs estimate estimates evaluate explain expressed expression expression level expression levels Gene Expression Genotype genotypes help HLA HLA allele HLA alleles HLA gene HLA genes HLA region HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRA HLA-DRB1 Human Leukocyte Antigens immune immune adaptive response influence information leukocyte Lineage lineages loci mapping nine organism P-value p-values paralogues phenotype Phenotypes predisposition problem qPCR quantification reference genome Regulation Regulatory remained RNA RNA-Seq sequence susceptibility target Transcriptome Variation [DOI] 10.1371/journal.pgen.1008091 PMC 바로가기 [Article Type] Research Article