Multi-target molecular dynamic simulations reveal glutathione-S-transferase as the most favorable drug target of knipholone in Plasmodium falciparumArticle Published on 2023-12-312024-09-09 Journal: J Biomol Struct Dyn [Category] 말라리아, [키워드] Density functional theory drug targets in silico knipholone molecular dynamics molecular mechanism. Plasmodium falciparum PMC 바로가기
Comparative spatial proteomics of Plasmodium-infected erythrocytesArticle Published on 2023-11-282024-08-29 Journal: Cell Reports [Category] 말라리아, [키워드] annotation CP: Microbiology drug targets erythrocyte modification Evolution exportome host-pathogen interaction malaria pan-species Pathogenesis
Cutting-edge advances in modeling the blood–brain barrier and tools for its reversible permeabilization for enhanced drug delivery into the brainarticle Published on 2023-07-272024-09-05 Journal: Cell & Bioscience [Category] update2024, [키워드] Blood–brain barrier drug delivery drug targets Focused ultrasound in vitro models in vivo models Intra-arterial infusion Organoid models [DOI] 10.1186/s13578-023-01079-3 PMC 바로가기 [Article Type] article
Subtractive proteomics analysis to uncover the potent drug targets for distinctive drug design of Candida aurisResearch Article Published on 2023-06-062024-09-05 Journal: Heliyon [Category] update2024, [키워드] Candida auris drug targets in silico Approach MD simulation molecular docking potential drugs [DOI] 10.1016/j.heliyon.2023.e17026 PMC 바로가기 [Article Type] Research Article
Updates on drug designing approach through computational strategies: a reviewarticle Published on 2023-05-042024-09-05 Journal: Future Science OA [Category] update2024, [키워드] computer-aided drug discovery drug targets Medicinal molecular docking Molecular dynamic repurposing [DOI] 10.2144/fsoa-2022-0085 PMC 바로가기 [Article Type] article
Deciphering the complete human-monkeypox virus interactome: Identifying immune responses and potential drug targetsArticle Published on 2023-03-272023-06-09 Journal: Frontiers in Immunology [Category] Fulltext, 원숭이두창, [키워드] Computational modelling drug targets Human immune response Monkeypox virus protein-protein interactions [DOI] 10.3389/fimmu.2023.1116988 PMC 바로가기
Structural insights into the activity regulation of full-length non-structural protein 1 from SARS-CoV-2Article Published on 2023-01-062024-09-05 Journal: Structure (London, England : 1993) [Category] update2024, [키워드] disordered protein domains drug targets NMR spectroscopy non-structural proteins nsp1 SARS-CoV-2 [DOI] 10.1016/j.str.2022.12.006 PMC 바로가기 [Article Type] Article
Unpacking COVID-19 Systems Biology in Lung and Whole Blood with Transcriptomics and miRNA RegulatorsArticle Published on 2022-11-012023-07-10 Journal: Omics : a journal of integrative biology [Category] COVID19(2023년), [키워드] Biomarkers COVID-19 drug targets miRNAs Systems biology systems medicine [DOI] 10.1089/omi.2022.0104
Multi-ancestry Mendelian randomization of omics traits revealing drug targets of COVID-19 severityResearch article Published on 2022-07-012022-10-05 Journal: EBioMedicine [Category] 신약개발, 유전자 메커니즘, 임상, [키워드] adverse effect African applied approach clinical investigation Colocalization complex complications conducted coronavirus disease COVID-19 COVID-19 severity COVID-19 treatments drug drug target drug targets Effect ENTPD5 European Europeans event Evidence FCRL3 finding funding genetics GWAS highlight ICAM1 ICAM5 immune system information mendelian randomization Multi-ancestry OAS1 Odds ratio other disease populations Protein protein targets provide provided recent reduce replicated risk sensitivity analysis SERPINA1 severity suggested target targets transcript Trial [DOI] 10.1016/j.ebiom.2022.104112 [Article Type] Research article
The effects of SARS-CoV-2 infection on modulating innate immunity and strategies of combating inflammatory response for COVID-19 therapyReview Published on 2022-05-032023-07-02 Journal: Journal of Biomedical Science [Category] COVID19(2023년), SARS, [키워드] drug targets Inflammatory response Innate immunity SARS-CoV-2 [DOI] 10.1186/s12929-022-00811-4 PMC 바로가기 [Article Type] Review