endothelial marker – Communicable Diseases Research

Alveolar, Endothelial, and Organ Injury Marker Dynamics in Severe COVID-19

심각한 COVID-19의 폐포, 내피 및 장기 손상 마커 역학

Observational Study

Published on 2022-03-012022-09-11
Journal: American Journal of Respiratory and Critical Care [Category] MERS, SARS, 바이오마커, 임상,

Elevated plasma levels of epithelial and endothelial cell markers in COVID-19 survivors with reduced lung diffusing capacity six months after hospital discharge

병원 배출 6 개월 후 폐 확산 능력 감소 된 Covid-19 생존자에서 상피 및 내피 세포 마커의 혈장 수준 증가

Observational Study

Published on 2022-02-212022-09-01
Journal: Respiratory Research [Category] MERS, 바이오마커, 임상, 진단,

[키워드] abnormality acute disease acute respiratory distress acute respiratory distress syndrome Adhesion Molecule angiopoietin ARDS carbon monoxide Cell Characteristics circulating clinical Clinical characteristics COVID-19 diffusing diffusing capacity discharge disease DLCO Dyspnoea E-selectin elevated endothelial Endothelial cell endothelial marker Endothelial markers epithelial Epithelial markers Follow-up hospital discharge Hospitalization hypertension independent risk factor independent risk factors individuals intercellular intercellular adhesion molecule leukocyte Level lung lung damage Lung function marker multivariate regression analysis observational study Occurrence Older Organizing pneumonia pathophysiology Patient patients plasma Plasma levels Pneumonia Post-COVID Prospective Protease inhibitor Protein Pulmonary embolism pulmonary embolisms reduced respiratory distress Result risk factor Risk factors selectin Sequelae severe COVID-19 severity Severity Score SLPI Smokers spirometry suffered supplementary material survivor Survivors syndrome
[DOI] 10.1186/s12931-022-01955-5 PMC 바로가기 [Article Type] Observational Study

Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19

Tie2 활성화는 COVID-19의 혈전성 내피 기능 장애로부터 보호합니다

Research Article

Published on 2021-10-222022-09-10
Journal: JCI Insight [Category] SARS, 유전자 메커니즘,

[키워드] accompany Activation AKB-9778 alteration angiopoietin Anticoagulant Antithrombotic assessment Autopsy changes in circulating Coagulation Cohort Concentration COVID-19 demonstrated disease severity Disruption dysfunction endothelial Endothelial cell endothelial cells Endothelial dysfunction endothelial marker Endothelial markers expression Genes highest highlight Inflammation inhibit inhibited Microvascular thrombosis Mild moderate Patient patients with COVID-19 Pharmacologic phenotypic plasma procoagulant promoted property PROTECT prothrombotic prothrombotic state rationale receptor released reversed severe COVID-19 Signaling small molecule survival therapy These data thrombosis treated Trial upregulated Vascular Biology
[DOI] 10.1172/jci.insight.151527 PMC 바로가기 [Article Type] Research Article

Soluble angiotensin-converting enzyme 2 is transiently elevated in COVID-19 and correlates with specific inflammatory and endothelial markers

가용성 안지오텐신 전환 효소 2는 COVID-19에서 일시적으로 상승하고 특정 염증 및 내피 표지자와 상관관계가 있습니다

Article

Published on 2021-10-012022-09-11
Journal: Journal of medical virology [Category] MERS, SARS, 바이오마커,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 cell type cell types consequence coronavirus coronavirus disease Coronavirus disease 2019 correlated correlation correlations COVID-19 COVID-19 patient D-dimer disease severity ectodomain elevated Endothelial dysfunction endothelial marker enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay factor VIII Follow-up healthy controls healthy controls; infected cells Inflammation Inflammatory Inflammatory marker inflammatory markers inhibitor Interaction interleukin interleukin 6 interquartile range investigated Level main entry receptor marker median men Necrosis not affected not differ outcome pathology patients remained Renin renin angiotensin system renin-angiotensin system respiratory risk factor sACE2 SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe COVID-19 soluble ACE2 survival Tumor tumor necrosis tumor necrosis factor tumor necrosis factor α vascular beds von Willebrand factor women
[DOI] 10.1002/jmv.27144 PMC 바로가기 [Article Type] Article

Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity

비만이 있는 COVID-19 환자에서 염증성 사이토카인과 다기관 기능 장애 사이의 차별적 연관성

Research Article

Published on 2021-05-262022-09-10
Journal: PLoS ONE [Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] Admission association BMI body mass body mass index categories chemokines clinical implications Computed tomography Computed tomography scans consolidation correlated COVID-19 patient cytokine cytokine levels Cytokines Endothelial dysfunction endothelial marker Endothelial markers flow cytometric function ground-glass opacity groups hepatic steatosis Hospitalization Immune cell immune parameter independent independent of Infection Inflammatory cytokine Inflammatory cytokines intensive care lesion liver lung damage mechanism Multiorgan dysfunction normal weight obesity on admission Patient patients patients with obesity performed physiopathological mechanism Prospective Study quantified renal reveal SARS-CoV-2 SARS-COV-2 infection severity steatosis subset the SARS-CoV-2 tomography was performed zenith
[DOI] 10.1371/journal.pone.0252026 PMC 바로가기 [Article Type] Research Article

ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 Patients

중환자실 COVID-19 환자의 사망률 예측인자로서의 내피 바이오마커의 ICU 입원 수준

Observational Study

Published on 2021-01-192022-09-11
Journal: Cells [Category] MERS, 바이오마커, 임상,

[키워드] Adhesion Molecule Admission Ang-1 angiopoietin association Biomarker Biomarkers characteristic Cohort COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients determine died E-selectin elevated endothelial endothelial damage endothelial marker Endothelial markers endotheliopathy greater growth factor hospitalized patients ICU ICU admission Ill intensive care intensive care unit intercellular intercellular adhesion molecule involved Kaplan–Meier analysis Level marker Mortality non-survivor observational study predict Probability Prognostic value receiver operating characteristic ROC ROC Curve sE-selectin selectin sICAM-1 significantly sP-selectin suggested survival survivor Survivors Vascular vascular endothelial growth factor VEGF von Willebrand factor was used were assessed were measured
[DOI] 10.3390/cells10010186 PMC 바로가기 [Article Type] Observational Study