Small-Molecule RAF265 as an Antiviral Therapy Acts against PEDV InfectionArticle Published on 2022-10-152022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 치료제, [키워드] Act acute diarrhea anticancer Antiviral antiviral strategy cause caused cellular cellular translation Concentration coronavirus cytoskeleton. drug effective epidemic diarrhea family Coronaviridae high mortality host cell inhibited inhibitor inhibitory activity magnitude Newborn PEDV pseudotyped RAF265 reduced reduced viral load Replication shown starting point translation treat Vero cells viral entry viral infection Viral vector virus vomiting [DOI] 10.3390/v14102261 PMC 바로가기
Mechanisms of host type I interferon response modulation by the nucleocapsid proteins of alpha- and betacoronaviruses알파 및 베타 코로나바이러스의 뉴클레오캡시드 단백질에 의한 숙주 유형 I 인터페론 반응 조절 메커니즘Review Published on 2022-10-012022-09-11 Journal: Archives of Virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha animals Antiviral antiviral responses Betacoronavirus cause coronavirus Coronavirus infections COVID-19 pandemic Critical diarrhea epidemic diarrhea facilitate Fatality rate function genomic RNA Health Host Human humans initial innate immune response involved knowledge modulate modulation Neonatal nucleocapsid protein Nucleocapsid proteins PEDV Replication responses responsible SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown Signaling type I interferon viral genomic RNA Viral RNA virions virus Virus-host interactions [DOI] 10.1007/s00705-022-05513-8 PMC 바로가기 [Article Type] Review
Development of passive samplers for the detection of SARS-CoV-2 in sewage and seawater: Application for the monitoring of sewage하수 및 해수 내 SARS-CoV-2 검출을 위한 패시브 샘플러 개발: 하수 모니터링을 위한 응용Article Published on 2022-08-102022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] application both virus both viruses collected Concentration conducted coronavirus correlated determine development diarrhea epidemic diarrhea Epidemiology Evolution Frequency Genome immersion inactivated increase in influent membrane membranes no significant difference Norovirus Nylon Passive Passive samplers PEDV Polymer public health recent SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 genome Seawater sewage shown significant difference significantly higher the SARS-CoV-2 Treatment virus virus detection viruses wastewater Wastewater- seawater. water [DOI] 10.1016/j.scitotenv.2022.155139 PMC 바로가기 [Article Type] Article
Discrimination and surveillance of infectious severe acute respiratory syndrome Coronavirus 2 in wastewater using cell culture and RT-qPCR세포배양과 RT-qPCR을 이용한 폐수 내 감염성 중증급성호흡기증후군 코로나바이러스 2의 감별 및 감시Article Published on 2022-04-012022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addressed applied Cell culture coronavirus coronavirus 2 CoV demonstrated determine develop diarrhea discrimination eliminating epidemic diarrhea Epidemiology evaluate FIVE Health Health risks heat heat-inactivated inactivated Infectivity information investigated knowledge lack Nuclease nucleic acid nucleic acids outlet PEDV performed plant Portugal positive provide public health purified RNA qPCR reagent Reagent D risk RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 infectivity SARS-CoV-2 RNA SARS-CoV-2 viral particle selective severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Surveillance treated Treatment urban Urban water cycle Vero E6 VERO E6 cell culture viability viability RT-qPCR virus water water cycle [DOI] 10.1016/j.scitotenv.2022.152914 PMC 바로가기 [Article Type] Article
Phylogeography Reveals Association between Swine Trade and the Spread of Porcine Epidemic Diarrhea Virus in China and across the WorldDiscoveries Published on 2022-02-242022-10-29 Journal: Molecular Biology and Evolution [Category] Coronavirus, [키워드] Animal coronaviruses bat Bayesian inference BEAST China complex Containment measure Coronaviridae Coronaviruses country dispersal epidemic diarrhea Epidemics Evolution explain extension family Coronaviridae Generalized linear model genus Alphacoronavirus Guangdong hazard highest implication increasingly initial Japan knowledge lineages Local maintain pandemic PEDV phylogeographic analysis phylogeography Porcine epidemic diarrhea virus predictor variable sequence sequenced samples Spread the United State Trade virus widespread [DOI] 10.1093/molbev/msab364 PMC 바로가기 [Article Type] Discoveries
Current Status of Genetically Modified Pigs That Are Resistant to Virus InfectionReview Published on 2022-02-172022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] African Antiviral antiviral pigs ASFV Bes classical CRISPR/Cas9 library CSFV current disease effort epidemic diarrhea Factor feasible Fever gastroenteritis generate Government Host host factors host receptor key amino acid knowledge library screening offer PEDV pig problem producing PRRSV PRV reproductive Resistant status sustained syndrome TGEV Tolerance virus virus infection viruses widespread [DOI] 10.3390/v14020417 PMC 바로가기 [Article Type] Review
Recovery of SARS-CoV-2 from large volumes of raw wastewater is enhanced with the inuvai R180 systeminuvai R180 시스템으로 대량의 원폐수에서 SARS-CoV-2 회수가 향상됨Article Published on 2022-02-152022-09-11 Journal: Journal of environmental management [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis applicability approach average circulation Community complement Concentration coronavirus 2 diarrhea early stage early stages effective epidemic diarrhea Epidemiology evaluate evaluated favor feature fiber filtration glycol groups inhibitory limits Limits of detection Methods performance and evaluation microbial outbreak overcome PEDV percentage plant Polyethylene glycol powerful tool Prevalence protocol quantification required SARS-CoV-2 scalability Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 Surveillance Treatment Usage Variability viral concentrations virus Volume wastewater Wastewater-based epidemiology water [DOI] 10.1016/j.jenvman.2021.114296 PMC 바로가기 [Article Type] Article
Ergosterol Peroxide Inhibits Porcine Epidemic Diarrhea Virus Infection in Vero Cells by Suppressing ROS Generation and p53 ActivationArticle Published on 2022-02-152022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Activation antiviral activity Apoptosis biological activity cause caused decrease diarrhea epidemic diarrhea ergosterol ergosterol peroxide Generation highlight Infection inhibit inhibitor inhibitory effect life cycle mitochondrial membrane potential morbidity and mortality NAC not affect p53 PEDV peroxide Porcine epidemic diarrhea virus Prevent Replication resulting ROS ROS production significantly Stage suppressed Suppressing therapeutic potential Vero Vero cells viral replication virus watery [DOI] 10.3390/v14020402 PMC 바로가기 [Article Type] Article
Modulation of Innate Antiviral Immune Response by Porcine Enteric CoronavirusMicrobiology Published on 2022-02-142022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute diarrhea Antiviral antiviral immune response antiviral immune responses component coronavirus Coronaviruses Defense diarrhea effective eliminating enteric epidemic diarrhea evade Factors gastroenteritis host cell Immune escape immune evasion Infection inhibit Innate Innate immunity innate immunity response Interaction interferon mechanism Neonatal other coronaviruses pathogenic PDCoV PEDV Porcine deltacoronavirus porcine enteric coronaviruses response SADS-CoV target TGEV viral infections virus [DOI] 10.3389/fmicb.2022.845137 PMC 바로가기 [Article Type] Microbiology
In Silico Infection Analysis (iSFA) Identified Coronavirus Infection and Potential Transmission Risk in MammalsMolecular Biosciences Published on 2022-02-082022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ACE2 Analysis applied binding affinity comprehensive analysis contributing to coronavirus Coronavirus infection Coronaviruses COVID-19 Cross-species transmission Data mining demonstrated Diseases downregulated epidemic diarrhea Equus expression FIVE Genome Host Identified in silico in silico docking in silico infection analysis include infect Infection intestine lung mammal network analysis pathogen PEDV performed Potential public health receptor S1 protein SARS-CoV-2 suggested the epidemic transcript Transcriptome transcriptome dataset Transmission virus wild animals [DOI] 10.3389/fmolb.2022.831876 PMC 바로가기 [Article Type] Molecular Biosciences