CovidConvLSTM: A fuzzy ensemble model for COVID-19 detection from chest X-raysResearch article Published on 2022-11-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 치료기술, [키워드] Accuracy activity affected applied chest X-ray Chest X-ray images CNN comparable ConvLSTM COVID-19 datasets deep learning ENhance experiments feature Features Fuzzy ensemble IMPROVE Local mechanism memory outbreak Pneumonia prevalent Research Spread Sugeno integral virus [DOI] 10.1016/j.eswa.2022.117812 [Article Type] Research article
Computational Design and Experimental Validation of ACE2-Derived Peptides as SARS-CoV-2 Receptor Binding Domain InhibitorsArticle Published on 2022-10-202022-11-16 Journal: The journal of physical chemistry. B [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding Algorithm Alpha variant bind binding binding affinity candidate caused Concentration concentrations COVID-19 pandemic demonstrated disrupt domain ELISA assays entry of SARS-CoV-2 experiments expressed globe host cells human cells inhibitory initial insoluble Interaction moderate Molecular dynamics simulation molecule peptidase peptide Prevent Protein RBD SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2-RBD sequence spike the RBD the SARS-CoV-2 therapeutic These data validation variants virus entry was used Wuhan-Hu-1 α1 helix [DOI] 10.1021/acs.jpcb.2c03918 PMC 바로가기
Patient preferences and current practice for adults with steroid-resistant ulcerative colitis: POPSTER mixed-methods studyArticle Published on 2022-10-012022-11-15 Journal: Health technology assessment (Winchester, England) [Category] 진단, [키워드] administration assessment carried Characteristics Consensus COVID-19 pandemic drug duration of symptom Effectiveness evaluate experiment experiments Factor Future greater Health personnel health-care highlight IMPROVE Inflammatory bowel disease influence information journal lack less library Necrosis NHS NIHR offered over Patient Patient preference patients per day predicted Prednisolone preference preferences Probability professional professionals qualitative research randomised controlled trial Randomised controlled trials recommendation Research respond risk sample sizes secondary care Selection bias severity Side effect Side effects subject surveys and questionnaires Symptoms technology therapeutic benefits Tofacitinib Treatment ulcerative ulcerative colitis undergo website [DOI] 10.3310/RHXR5192 PMC 바로가기
No infectious SARS-CoV-2 in breast milk from a cohort of 110 lactating womenArticle Published on 2022-10-012022-11-15 Journal: Pediatric Research [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition analyzed Breast breast milk Breastfeeding breastmilk Cohort coronavirus Culture detectable diagnostic diagnostic tests Evidence examined experiments freeze-thaw cycles human milk Infants Infection Infectious virus lactating women marker occur positive recent remained risk factor RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 viral RNA sgRNA Symptom symptomatic tested Transmission viral culture virus vRNA women [DOI] 10.1038/s41390-021-01902-y PMC 바로가기
Activity of ertapenem/zidebactam (WCK 6777) against problem EnterobacteralesArticle Published on 2022-09-302022-11-16 Journal: Journal of Antimicrobial Chemotherapy [Category] SARS, 비임상, [키워드] 1:1 active against activity administration breakpoint Dilution E. coli Escherichia coli evaluated experiments group healthcare increasingly indicated Infection inhibited isolate Klebsiella KPC Laboratory material MDR National nosocomial Outpatient over Parenteral pathogen Patient proportion regimen SARS-CoV-2 secondary submitted Support susceptibility Trial will drive [DOI] 10.1093/jac/dkac280 PMC 바로가기
SARS-CoV-2-specific immunoglobulin Y antibodies are protective in infected miceArticle Published on 2022-09-192022-11-15 Journal: PLoS Pathogens [Category] SARS, 변종, 진단, 치료제, [키워드] acute respiratory syndrome Ad5-hACE2 administration antibody Antigen applied characterized control group Coronavirus-2 disease edema Efficacy evaluated Evidence examined experiments hemorrhage Human immunization Immunoglobulin increased survival induce inflammatory cell infiltration injected intranasal lung mice Mild morbidity non-specific plaque reduction neutralization Prophylactic Protective Recombinant SARS-CoV-2 RBD reduced required safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SDS-PAGE severe disease variants virus [DOI] 10.1371/journal.ppat.1010782 PMC 바로가기
SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 proteinArticle Published on 2022-09-122022-11-15 Journal: PLoS Pathogens [Category] SARS, 치료제, [키워드] activities antiviral response binding catalytic domain Cell cellular metabolism complexes conserved Critical enzyme exhibit experiments expressed form group inhibitor Innate immunity interact Interaction investigated knock-out lysine marker MAVS mounted non-structural protein Protein reduced residues SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral SIRT5 stable complex therapeutic interventions Treatment viral replication [DOI] 10.1371/journal.ppat.1010811 PMC 바로가기
SARS-CoV-2 Production, Purification Methods and UV Inactivation for Proteomics and Structural StudiesArticle Published on 2022-09-082022-11-16 Journal: Viruses [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome biosafety can be used cell activation conditions core Coronavirus-2 COVID-19 died downstream effective experiments faster handling inactivated inactivation Laboratory Microscopy pandemic pathogenicity Production purification resulting SARS-CoV-2 Sequencing Seven significantly size exclusion structural studies. sucrose cushion ultracentrifugation UV inactivation virus [DOI] 10.3390/v14091989 PMC 바로가기
New Chemicals Suppressing SARS-CoV-2 Replication in Cell CultureArticle Published on 2022-09-052022-11-15 Journal: Molecules [Category] SARS, 치료제, [키워드] antiviral drug binding calculated candidate Cell Cell culture Chemical Compound coronavirus cytotoxicity database derivatives develop docked docking EC50 value experiment experiments inhibit SARS-CoV-2 inhibitor inhibitors Ligand main protease molecular MPro New protease protein-ligand quantum chemistry. Replication SARS-CoV-2 SARS-CoV-2 replication selected Selection Seven solvent state suppressed Suppressing the SARS-CoV-2 university Vero E6 [DOI] 10.3390/molecules27175732 PMC 바로가기
Directional mutation and crossover boosted ant colony optimization with application to COVID-19 X-ray image segmentationResearch article Published on 2022-09-012022-10-05 Journal: Computers in biology and medicine [Category] 변종, 치료기술, [키워드] Accuracy ACO Algorithm Ant colony optimization competing COVID-19 COVID-19 X-ray directional ENhance experiment experiments faster Image segmentation IMPROVE increase Local Mutation optimization Other Swarm intelligence threshold two-dimensional Validity were used X-ray [DOI] 10.1016/j.compbiomed.2022.105810 [Article Type] Research article