BNT162b2-induced neutralizing and non-neutralizing antibody functions against SARS-CoV-2 diminish with ageArticle Published on 2022-10-252022-11-15 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome addition age antibody Antibody glycosylation BNT162b2 mRNA vaccine breadth coronavirus COVID-19 CP: Immunology disease domain dose Efficacy Fab Fc effector functions Fc function Fc receptor FIVE function functions greater immune cells Immunity individual induce Infection isolate magnitude neutralization neutralize Neutralizing Neutralizing activity non-neutralizing antibody omicron polyclonal antibody populations promote provide response SARS-CoV-2 SARS-CoV-2 variants sera uninfected Vaccine vaccine-specific antibodies vaccine. variant variants virus wild-type [DOI] 10.1016/j.celrep.2022.111544 PMC 바로가기
Isolation of a human SARS-CoV-2 neutralizing antibody from a synthetic phage library and its conversion to fluorescent biosensorsArticle Published on 2022-09-152022-11-15 Journal: Scientific Reports [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome addition angiotensin-converting enzyme 2 antibody antibody fragment antigen detection binding Clinical treatment clone coronavirus demonstrated diagnose effective Fab fluorescent Health help Human monoclonal antibody human SARS-CoV-2 IgG neutralize neutralizing antibody outbreak Prevent public health S protein S1 domain SARS-CoV-2 selected spike glycoprotein spread of COVID-19 viral infection viral infections virus detection [DOI] 10.1038/s41598-022-19699-z PMC 바로가기
Passive immunization with equine RBD-specific Fab protects K18-hACE2-mice against Alpha or Beta variants of SARS-CoV-2Article Published on 2022-08-152022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] ACE2 receptor binding addition administration antibody Beta clearance contributed country COVID-19 COVID-19 pandemic creating delta variant disease dose doses Efficacy emergence EpF(ab’)2 equine Equine F(ab’)2 Fab HBsAg immunization implementation increased survival Infection intranasal K18-hACE2 K18-hACE2 transgenic mice mice monoclonal antibody treatment neutralize omicron outcome pandemic passive immunization peripheral circulation phenotype polyclonal polyclonal antibodies PROTECT RBD SARS-CoV-2 SARS-COV-2 infection Severe case severe disease severe SARS-CoV-2 strain survival tested therapeutic Therapeutic treatment tissues transgenic Treatment variant Variant of concern (VOC). variants variants of concern variants of SARS-CoV-2 Viral RNA virus VoC [DOI] 10.3389/fimmu.2022.948431 PMC 바로가기
Antibodies induced by an ancestral SARS-CoV-2 strain that cross-neutralize variants from Alpha to Omicron BA.1Alpha에서 Omicron BA.1까지 변이체를 교차 중화하는 조상 SARS-CoV-2 균주에 의해 유도된 항체Article Published on 2022-08-122022-09-11 Journal: Science Immunology [Category] Fulltext, SARS, 변종, 진단, [키워드] ACE2 binding antibodies antibody B cell binding binding site breadth caused Cell Clusters complexes cross-neutralize Defense defined Delta determinant determinants determine disease driven by Efficacy escape Fab FIVE greater highest Host host defense identifying Immune escape immune protection Infection initial memory B memory B cell Mitigation Mutation neutralization neutralization potency neutralize neutralized Neutralizing activity Neutralizing antibodies neutralizing antibody omicron Prevalence RBD real-world data Receptor binding domain recognize recognizing Region SARS-CoV-2 SARS-CoV-2 spike glycoprotein SARS-CoV-2 strain sensitivity Specificities specificity spike glycoprotein Spike receptor binding domain Structure structures tested the RBD the SARS-CoV-2 Vaccine vaccine efficacy variant variants variants of concern Viral viral escape viral invasion Wuhan strain [DOI] 10.1126/sciimmunol.abo3425 PMC 바로가기 [Article Type] Article
Template-Based Assembly of Proteomic Short Reads For De Novo Antibody Sequencing and Repertoire ProfilingDe Novo 항체 시퀀싱 및 레퍼토리 프로파일링을 위한 Proteomic Short Read의 템플릿 기반 어셈블리Review Published on 2022-07-262022-09-11 Journal: Analytical Chemistry [Category] MERS, 유전자 메커니즘, 진단, [키워드] Accuracy antibody antibody repertoire antibody sequence antibody sequences antigens assembly B-cells cDNA sequencing complementary dataset de novo disease Fab feature fluids foundation functional Health homologous homologous antibody hypermutation IgG information light chains Liquid chromatography mass mass spectrometry molecular monoclonal antibody offer Patient patients hospitalized polyclonal polyclonal antibodies polyclonal antibody Profiling proteomic provide Read Recombination repertoire secreted sequence Sequencing sera serological assays serum step Stitch Urine with COVID-19 [DOI] 10.1021/acs.analchem.2c01300 PMC 바로가기 [Article Type] Review
Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeysArticle Published on 2022-07-252022-10-05 Journal: Nature Microbiology [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] class Combination Complete complex Cryo-electron microscopy Donor epitope Fab Human monoclonal antibody identify in vitro less mAb monoclonal antibody Mutation neutralization neutralize Neutralizing activity omicron other variant Prophylactic reported SARS-CoV-2 SARS-CoV-2 mutant sequence spike epitope tested therapeutic therapy Transmission vaccine-mediated immunity variant [DOI] 10.1038/s41564-022-01198-6 [Article Type] Article
35B5 antibody potently neutralizes SARS-CoV-2 Omicron by disrupting the N-glycan switch via a conserved spike epitope35B5 항체는 보존된 스파이크 에피토프를 통해 N-글리칸 스위치를 방해하여 SARS-CoV-2 Omicron을 강력하게 중화합니다.Article Published on 2022-06-082022-09-11 Journal: Cell Host & Microbe [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 35B5 ACE2 antibody antigenic antigenic shift change changes conformational change conserved Control cryo Cryo-electron microscopy disrupting dissociation domain Efficacy electron microscopy entry receptor epitope exhibit Extracellular Fab glycan Host immune evasion Microscopy monoclonal monoclonal antibody Mutation N-terminal domain neutralization neutralize Neutralizing Neutralizing antibodies neutralizing capacity not affect NTD omicron other variant other variants RBD Receptor-binding domain Recognition SARS-CoV-2 Spike protein spike protein. Structure the RBD the spike protein therapeutic transition trimer trimeric variant [DOI] 10.1016/j.chom.2022.03.035 PMC 바로가기 [Article Type] Article
Addition of arginine hydrochloride and proline to the culture medium enhances recombinant protein expression in Brevibacillus choshinensis: The case of RBD of SARS-CoV-2 spike protein and its antibodyarginine hydrochloride와 proline을 배지에 첨가하면 Brevibacillus choshinensis에서 재조합 단백질 발현이 향상됩니다: SARS-CoV-2 스파이크 단백질의 RBD 및 그 항체의 경우Article Published on 2022-06-012022-09-11 Journal: Protein expression and purification [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 96-well plates addition analysis anti-SARS-CoV-2 antibody antibody arginine arginine hydrochloride B.1.1.529 Bacterial bacterial cell bacterial cells bacterial strains Brevibacillus Cell condition contribute CoV-2 Culture culture medium demonstrated ENhance Escherichia coli eukaryotic eukaryotic cell exhibited expressed expression Fab functional functional expression gram-positive bacterium High-throughput expression and purification indicated medium Omicron variant physicochemical produced producing proline Protein protein expression Proteins purification RBD RBD of SARS-CoV-2 RBD. Receptor binding domain recombinant proteins reported SARS-CoV-2 spike protein secrete Spike protein strain the SARS-CoV-2 wild-type [DOI] 10.1016/j.pep.2022.106075 PMC 바로가기 [Article Type] Article
Structures of Omicron spike complexes and implications for neutralizing antibody developmentOmicron 스파이크 복합체의 구조 및 중화 항체 개발에 대한 의미Article Published on 2022-05-032022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 antibodies antibody Antibody binding Antibody structure binding biochemical complexes country CP: Immunology CP: Microbiology cryo Cryo-electron microscopy cryo-EM cryo-EM structures Delta dominant drugs electron microscopy Evidence explain Fab immune immune evasion immunology implication information interactions lead Microbiology Mutation mutations neutralization Neutralization antibody neutralization assays neutralizing antibody omicron provide required responsible SARS-CoV-2 spike spike mutation spike mutations Spike. Structure structures the SARS-CoV-2 therapeutic therapeutic antibodies Vaccine variant wild-type [DOI] 10.1016/j.celrep.2022.110770 PMC 바로가기 [Article Type] Article
A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection인간 항체는 베타-코로나바이러스 스파이크 단백질의 보존된 부위를 드러내고 SARS-CoV-2 감염에 대한 보호를 제공합니다Research Article Published on 2022-02-082022-09-14 Journal: Science Translational Medicine [Category] MERS, SARS, 진단, 치료기술, [키워드] adopted animal models antibody beta-coronavirus beta-coronavirus conserved controls coronavirus coronavirus coronavirus disease CoV COVID-19 COVID-19 infection CoVs cross-neutralizing described description Donor Efficacy epitope exhibit exhibited Fab facilitate helical structure in vivo less lung viral titer mAb molecular basis neutralizing antibody peptide Prophylactic Protective Protective antibody reactivity reagent reduced residue reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S2 Spike protein target therapeutic treat Vaccine design Vaccines weight loss β-CoV β-CoVs [DOI] 10.1126/scitranslmed.abi9215 PMC 바로가기 [Article Type] Research Article