The failure of drug repurposing for COVID-19 as an effect of excessive hypothesis testing and weak mechanistic evidenceArticle Published on 2022-10-182022-11-16 Journal: History and philosophy of the life sciences [Category] COVID19(2023년), SARS, 신약개발, [키워드] agency Analysis applied approval clinical trial Compound conducted COVID COVID-19 EBM+ effective Efficacy Evidence example Excessive hypothesis testing explain false-positive result False-positive results favor Hydroxychloroquine Hypothesis less Mechanistic evidence Medical nihilism. Medicine ongoing trial other diseases Perspective risk second tested therapeutic therapy Treatment treatment for COVID-19 Trial [DOI] 10.1007/s40656-022-00532-9 PMC 바로가기
Development of a high-sensitivity and short-duration fluorescence in situ hybridization method for viral mRNA detection in HEK 293T cellsArticle Published on 2022-10-042022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome addition antibody Antigen applied approach Blood caused Cell Cell culture cells Concentration contagious coronavirus Coronavirus disease 2019 COVID-19 development Diagnosis disease DNA virus effective false-negative False-positive results faster Fluorescence in situ hybridization gold standard HEK 293T HEK 293T cell hepatitis A virus HPV Human immunodeficiency virus human papillomavirus IgM and IgG IMPROVE influenza viruses limitation MERS-CoV Middle East Monkeypox mRNA patients plasmids probe Protein public health reduced respiratory syndrome coronavirus RNA RNA virus RT-PCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 viral Sensitivity and specificity significantly spike Surveillance tissue Treatment virus was increased yielding [DOI] 10.3389/fcimb.2022.960938 PMC 바로가기
Performance of 22 Rapid Lateral Flow Tests for SARS-CoV-2 Antigen Detection and Influence of “Variants of Concern”: Implications for Clinical UseArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome Alpha Antigen clinical collected coronavirus Cutoff cycle threshold detect detection evaluate evaluated exhibited false-positive result False-positive results Flow head-to-head assessment influence Lateral lateral-flow tests less majority NAAT nucleic acid amplification Occurrence Omicron variant Omicron variants other variants Paris performance proportion ranged Rapid reduced required SARS CoV-2 SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 viral sensitivity Sensitivity and specificity specificity symptom onset Test tested variants variants of concern Viral load Viral variants virus VoC [DOI] 10.1128/spectrum.01157-22 PMC 바로가기
The Cyclophilin-Dependent Calcineurin Inhibitor Voclosporin Inhibits SARS-CoV-2 Replication in Cell Culture사이클로필린 의존성 칼시뉴린 억제제 보클로스포린은 세포 배양에서 SARS-CoV-2 복제를 억제합니다Article Published on 2022-06-242022-09-11 Journal: Transplant International [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral activity Antiviral assays assays benefit binding calcineurin calcineurin inhibitors can not clinical evaluation CNI Combination Comorbidity Compound compounds Concentration coronavirus Coronaviruses Course COVID-19 cyclophilin cyclosporin cyclosporin A EC50 value EC50 values evaluated experiments False-positive results human Calu-3 cell human Calu-3 cells Immunosuppressant immunosuppressants Immunosuppression immunosuppressive increased risk Infection inhibitor Interference kidney kidney transplant recipients Kidney transplantation lab progeny protocol recipient reduced reducing regimen reported RNA viruses SARS-CoV-2 SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus tacrolimus voclosporin voclosporin. with COVID-19 [DOI] 10.3389/ti.2022.10369 PMC 바로가기 [Article Type] Article
Dealing with inconclusive SARS-CoV-2 PCR samples-Our experience결론이 나지 않은 SARS-CoV-2 PCR 샘플 처리-우리의 경험Article Published on 2022-05-132022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI amplification Analysis analyzed clinical symptom Clinical symptoms collected Contact COVID-19 case COVID-19 cases COVID-19 testing demographic characteristics determine diagnostics epidemiological data False positive false-positive result False-positive results Genes Inconclusive infected patient infected patients Infection Italy Laboratory majority management material medical record medical records N-gene naso-oropharyngeal swab Naso-oropharyngeal swabs oropharyngeal swabs Patient positive positive sample proportion routine RT-PCR detection SARS-CoV-2 SARS-CoV-2 PCR SARS-CoV-2 positivity sequence subsequent tested the patient the SARS-CoV-2 unique virus were excluded [DOI] 10.1371/journal.pone.0268187 PMC 바로가기 [Article Type] Article
Potential for false-positive results with quantitative antigen tests for SARS-CoV-2: A case of a child with acute respiratory infectionSARS-CoV-2에 대한 정량 항원 검사에서 위양성 결과 가능성: 급성 호흡기 감염 아동 1례Case Reports Published on 2022-02-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), SARS, 치료기술, [키워드] Act Acute respiratory infection amplification Antigen Chain Reaction clinical information COVID-19 diagnosed with COVID-19 enterovirus infection enzyme enzyme immunoassay False positive False-positive false-positive result False-positive results Fever hospital Human rhinovirus immunoassay International Isolation Japan multiplex NAAT nucleic acid amplification tests performed polymerase chain polymerase chain reaction positive Potential Quantitative Quantitative antigen test quarantine rapid antigen test reported respiratory infection rhinorrhea rhinovirus SARS-CoV-2 while [DOI] 10.1016/j.jiac.2021.10.032 PMC 바로가기 [Article Type] Case Reports
Lung Cancer Screening Considerations During Respiratory Infection Outbreaks, Epidemics or Pandemics: An International Association for the Study of Lung Cancer Early Detection and Screening Committee Report호흡기 감염, 전염병 또는 유행병 중 폐암 검진 고려 사항: 국제 폐암 조기 발견 및 검진 위원회 보고서Article Published on 2022-02-012022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aims Cancer Cancer screening Care change Committee coronavirus coronavirus disease Coronavirus disease 2019 detection diagnostic procedures Early detection Epidemic evaluate false-positive result False-positive results Follow-up global pandemic Guidance Health Health care implementation Infection Interpretation invasive lead lesion lesions lung cancer Lung cancer screening malignancy management nodule other respiratory infection other respiratory infections outbreak pandemic patients randomized trials report Research respiratory respiratory infection respiratory infections risk of transmission Screening Screening and early detection. severe acute respiratory syndrome Coronavirus stimulate stoppage [DOI] 10.1016/j.jtho.2021.11.008 PMC 바로가기 [Article Type] Article
Specificity of SARS-CoV-2 Antibody Detection Assays against S and N Proteins among Pre-COVID-19 Sera from Patients with Protozoan and Helminth Parasitic Infections원생동물 및 기생충 기생충 감염 환자의 코로나19 이전 혈청 중 S 및 N 단백질에 대한 SARS-CoV-2 항체 검출 분석의 특이성Article Published on 2022-01-192022-09-11 Journal: Journal of Clinical Microbiology [Category] MERS, SARS, 진단, 치료기술, [키워드] 95% CI Abbott Abbott SARS-CoV-2 IgG acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African trypanosomiasis anti-SARS-CoV-2 IgG antibody Antibody detection Antibody test Architect clinically suspected collected coronavirus COVID-19 detection diagnostic Diagnostic accuracy diagnostic test estimate Evidence evidence of false false-positive result False-positive results filaria helminth helminth infections holoendemic IgG IgM IgM/IgG indicated Infection infections kinetoplastid infections majority malaria neglected tropical diseases Neutralization antibody option parasitic infections past Patient Patient care positive protozoan infection protozoan infections provide Rapid diagnostic test RDT required respiratory reticuloendothelial system SARS-CoV-2 SARS-CoV-2 neutralization Schistosoma sera Serological assay serological assays serology seropositive severe acute respiratory syndrome Coronavirus specificity specimen Standard Q Strongyloides tested threshold Trichinella tropical trypanosomiasis visceral leishmaniasis [DOI] 10.1128/JCM.01717-21 PMC 바로가기 [Article Type] Article
Obstetric interventions and pregnancy outcomes during the COVID-19 pandemic in England: A nationwide cohort study영국의 COVID-19 전염병 동안 산과적 중재 및 임신 결과: 전국적인 코호트 연구Research Article Published on 2022-01-102022-09-12 Journal: PLoS Medicine [Category] 진단, [키워드] 95% CI adjusted adjusted odds ratio age Birth Care caution Cesarean section chance changes in Characteristics cohort study Comorbidities comparison conducted COVID-19 COVID-19 pandemic database decrease defined diabete diabetes elective cesarean section emergency cesarean section England English environmental exposure Evidence evidence of exacerbated False-positive results gestational age Gestational diabetes hospital Hospital Episode Statistics hospitals hypertension in some increases in Interaction Intervention lockdown restriction lockdown restrictions logistic regression model Lower Maternal median age multiple comparison multiple comparisons National National Health Service Obstetric occurred outcome outcomes pandemic pattern preeclampsia Pregnancy Preterm birth preterm births primiparous provided Rate readmission reduced reduction in remained researcher Stillbirth Variation were used women [DOI] 10.1371/journal.pmed.1003884 PMC 바로가기 [Article Type] Research Article
Evaluation of different platforms for the detection of anti-SARS coronavirus-2 antibodies, Thailand항 -SARS 코로나 바이러스 2 항체의 검출을위한 다른 플랫폼의 평가, 태국Research Published on 2021-12-062022-09-01 Journal: BMC Infectious Diseases [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibodies antibody Antibody detection Architect assays Asymptomatic Chemiluminescence assay comparable coronavirus Coronavirus-2 country COVID-19 detect determine Disease diagnosis ELISA evaluated False-positive results feasibility four group four groups help IgG immunofluorescence assay immunological indirect immunofluorescence individuals Infection infection rate Laboratory large sample microneutralization Microneutralization assay Negative predictive value platform positive Positive predictive value Predictive value Prevalence respiratory Result risk SARS-coronavirus-2 SARS-CoV-2 SARS-CoV-2 antibodies sensitivity sera serum serum samples severe acute respiratory syndrome Coronavirus specificity symptomatic total Ig Vaccines [DOI] 10.1186/s12879-021-06921-y PMC 바로가기 [Article Type] Research