Ketones and the Heart: Metabolic Principles and Therapeutic ImplicationsArticle Published on 2023-06-022024-09-05 Journal: Circulation research [Category] update2024, [키워드] acetoacetate beta-hydroxybutyrate fatty acid oxidation heart failure HFpEF HFrEF hypertrophy Ketogenic diet ketone ketone ester sodium glucose cotransporter [DOI] 10.1161/CIRCRESAHA.123.321872 PMC 바로가기 [Article Type] Article
Modulation of Macrophage Immunometabolism: A New Approach to Fight InfectionsImmunology Published on 2022-01-262022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] accumulated amino acid metabolism Bacterial contribute Defense develop drug Evidence Extracellular fatty acid oxidation function Glycolysis Host immune function Immunity immunometabolism Infection infections innate immune cell Macrophage macrophage activation metabolic pathway New pentose phosphate pathway phenotype potential therapy regulate respond SARS – CoV – 2 SARS-CoV2 infection Therapeutic strategies Therapeutics viral infection [DOI] 10.3389/fimmu.2022.780839 PMC 바로가기 [Article Type] Immunology
PPAR agonists as effective adjuvants for COVID-19 vaccines, by modifying immunogenetics: a review of literatureReview Published on 2021-05-312022-10-30 Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19, [키워드] Abstract adjuvant agonist anti-apoptotic antibody Antigen boost coronavirus vaccine COVID-19 infection COVID-19 vaccine COVID-19 vaccines debatable Effect effective Factor fatty acid oxidation immune immune system Immunologic memory Immunological memory IMPROVE increasingly Interaction long-lived plasma cell mechanisms memory metabolism pandemic PD-L1 peroxisome persistence PPAR Re-infection receptor secretion Seroconversion stimulated switching T cell T cell memory T memory cells T regulatory cells the vaccine upregulating vaccination Vaccine [DOI] 10.1186/s43141-021-00179-2 PMC 바로가기 [Article Type] Review
Genome Scale-Differential Flux Analysis reveals deregulation of lung cell metabolism on SARS-CoV-2 infection게놈 규모-차이 플럭스 분석은 SARS-CoV-2 감염에 대한 폐 세포 대사의 규제 완화를 보여줍니다Research Article Published on 2021-04-092022-09-10 Journal: PLoS Computational Biology [Category] MERS, SARS, 유전자 메커니즘, [키워드] affected alteration Analysis applied arachidonic acid Author bronchial epithelial cell cholesterol conditions COVID-19 pandemic deregulation disease disturbance driving enzyme epithelial cells Fatty acid fatty acid oxidation flux gene-expression growth rate growth rates homeostasis Host host cells human cell identify imperative increasingly infected with SARS-CoV-2 Interaction lead lipid metabolism lung cell macromolecular mechanism metabolic metabolism metabolomics NHBE normal state Numerous pandemic Phosphorylation predict predicted probe protein-protein interaction proteomic reaction Reactions reconstructed reveal SARS-CoV-2 SARS-COV-2 infection therapeutic interventions transcriptomic data Viral protein Viral proteins virus while with COVID-19 [DOI] 10.1371/journal.pcbi.1008860 PMC 바로가기 [Article Type] Research Article
The SARS-CoV-2 induced targeted amino acid profiling in patients at hospitalized and convalescent stage입원 및 회복기 환자에서 SARS-CoV-2 유도 표적 아미노산 프로파일링Metabolism Published on 2021-03-262022-09-10 Journal: Bioscience Reports [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] AAAs acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid amino acids biochemical Combination complete recovery convalescent convalescent patient Convalescent patients convalescent stage coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 patients except for Fatty acid fatty acid oxidation fatty acids Health Health crisis Hospitalization Hospitalized hospitalized patients Infection inflammatory status Injury liver majority manifested metabolites methionine MOST Patient plasma Post-infection reduced respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus subject subjects suggested [DOI] 10.1042/BSR20204201 PMC 바로가기 [Article Type] Metabolism
Fatal COVID ‐19 infection in a patient with long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency: A case reportCase Report Published on 2020-09-102022-10-30 Journal: JIMD Reports [Category] COVID-19, [키워드] addition Arrhythmias cardiac function Cardiomyopathy Case report caused close monitoring Coronavirus disease 2019 cough COVID COVID‐19 COVID‐19 death deficiency disorder diverse presentation fatty acid oxidation fatty acid oxidation disorder feature hypoglycemia Infection LCHAD long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency Mild multiple organ failure myocarditis nausea pandemic Patient progressed Respiratory failure respiratory symptom RNA virus SARS‐CoV‐2 Symptom vomiting [DOI] 10.1002/jmd2.12165 PMC 바로가기 [Article Type] Case Report
Thymic Microenvironment Is Modified by Malnutrition and Leishmania infantum InfectionOriginal Research Published on 2019-07-122023-08-30 Journal: Frontiers in Cellular and Infection Microbiology [Category] E형 간염, [키워드] fatty acid oxidation interstitial fluid Leishmania infantum protein malnutrition proteomics thymic microenvironment thymus visceral leishmaniasis [DOI] 10.3389/fcimb.2019.00252 PMC 바로가기 [Article Type] Original Research
Increased mortality from influenza infection in long-chain acyl-CoA dehydrogenase knockout miceArticle Published on 2018-03-042023-06-24 Journal: Biochemical and Biophysical Research Communication [Category] 신종인플루엔자, [키워드] fatty acid oxidation Influenza Long-chain acyl-CoA dehydrogenase Lung injury [DOI] 10.1016/j.bbrc.2018.02.135 PMC 바로가기