Aspergillus detection in airways of ICU COVID-19 patients: To treat or not to treat?ICU COVID-19 환자의 기도에서 아스페르길루스 검출: 치료할 것인가, 말 것인가?Case Reports Published on 2022-08-012022-09-11 Journal: Journal de mycologie médicale [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, [키워드] absence airway Antifungal Antifungal treatment Antigen Aspergillus Aspergillus fumigatus Atypical COVID-19 Culture difficulty galactomannan highlight ICU ICU patient ICU Patients Intubated invasive Invasive pulmonary aspergillosis IPA management mechanically ventilated mechanically ventilated patient mechanically ventilated patients outcome Patient patients PCR Pneumonia pulmonary aspergillosis radiological Respiratory samples respiratory tract sample respiratory tract samples risk SARS CoV SARS CoV-2 SARS-CoV-2 SARS-CoV-2 pneumonia SARS-CoV-2. severe COVID-19 Symptomatology treat [DOI] 10.1016/j.mycmed.2022.101290 PMC 바로가기 [Article Type] Case Reports
Investigation of the value of precipitins in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients with a positive marker for Aspergillus speciesAspergillus 종에 대한 양성 마커를 가진 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 환자에서 침전물의 값 조사Article Published on 2022-05-282022-09-11 Journal: Medical mycology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, 치료제, [키워드] A. fumigatus acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus-2 Antigen antigens Aspergillus Aspergillus fumigatus assays Biomarker Biomarkers Bronchoalveolar lavage Characteristics Clinical data Co-infection collected colonization coronavirus Culture electrosyneresis ELISA galactomannan Hospitalized house hypersensitivity pneumonitis ICU ICU patient ICU Patients Infection intensive care intensive care unit investigation male management marker median microbial Patient patients performed positive precipitins Prevalence pulmonary aspergillosis purified qPCR reported respiratory respiratory sample Respiratory samples SARS CoV SARS CoV-2 SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 patients screened serology assays Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly higher similarities similarity somatic antigen study population suggested survival rate t-test tracheal Tracheal aspirates tracheal aspirates. [DOI] 10.1093/mmy/myac031 PMC 바로가기 [Article Type] Article
Prognostic Impact of Bronchoalveolar Lavage Fluid Galactomannan and Aspergillus Culture Results on Survival in COVID-19 Intensive Care Unit Patients: a Post Hoc Analysis from the European Confederation of Medical Mycology (ECMM) COVID-19-Associated Pulmonary Aspergillosis StudyObservational Study Published on 2022-04-202022-10-05 Journal: Journal of Clinical Microbiology [Category] 임상, [키워드] 95% CI adjusted Analysis aspergillosis Aspergillus association BALF Biomarker Bronchoalveolar lavage fluid can be used CAPA Combination conducted confidence interval coronavirus disease COVID-19 Critically ill patient Culture develop diagnosed enrolled European final multivariable model galactomannan galactomannan. GM hazard ratio heterogeneity Impact increasing age independent independent predictor intensive care unit lavage malignant disease Mortality MOST multicenter mycology optical Patient positive prognostic Prognostic value pulmonary Result survival with COVID-19 [DOI] 10.1128/jcm.02298-21 PMC 바로가기 [Article Type] Observational Study
Critically ill patients with COVID-19 show lung fungal dysbiosis with reduced microbial diversity in patients colonized with Candida spp.Research article Published on 2022-04-012022-10-05 Journal: International Journal of Infectious Diseases [Category] 바이오마커, [키워드] acute respiratory disease syndrome acute respiratory distress addition Affect Amplicon sequencing ARDS Ascomycota Aspergillus Bacterial Candida Cell characterized contribute corticosteroid therapy COVID-19 COVID-19 pandemic Critically ill patient decrease Dysbiosis fungal galactomannan Illumina Miseq Infection Lower respiratory tract lung microbial Microbiome Mycobiome Next-generation sequencing NGS Patient patients with COVID-19 patients without COVID-19 performed Phylogenetic platform Pneumonia positive reduced respiratory specimen Result spacer specimen syndrome transcribed with COVID-19 [DOI] 10.1016/j.ijid.2022.02.011 [Article Type] Research article
COVID-19-associated pulmonary aspergillosis in a tertiary care center in Shenzhen CityArticle Published on 2022-02-012022-11-16 Journal: Journal of infection and public health [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory distress Anti-Aspergillus IgG Antibody detection Antigen ARDS Aspergillus BALF Bronchoalveolar lavage fluid Care characterized China city clinical care Co-infection collected COVID-19 Culture diagnosed with COVID-19 Diagnosis died eight fungal galactomannan high mortality rate include invasive outcomes Patient positive positive result pulmonary aspergillosis Pulmonary aspergillosis. risk Sequencing analysis severe coronavirus disease Shenzhen single center sputum syndrome tested Therapies therapy underlying conditions [DOI] 10.1016/j.jiph.2021.12.015 PMC 바로가기
Targeting SARS‐CoV‐2 with Chaga mushroom: An in silico study toward developing a natural antiviral compoundOriginal Research Published on 2021-10-202022-10-31 Journal: Food Science & Nutrition [Category] COVID-19, [키워드] Inonotus obliquus addition antiviral activity average Beta beta‐glucan betulinic acid binding binding affinity binding energy binding interaction booster caused component Compound docking docking analysis docking result domain drugs effective Efficacy exhibited furin cleavage site galactomannan host cell immune imperative in silico indicated Infection Interaction involved isolate Ligand MD simulation molecular docking natural antiviral Novel coronavirus outbreak PHE Phylogenetic analysis Protein RBD receptor receptor‐binding domain residue SARS‐CoV‐2 SARS‐CoV‐2 targeting the RBD Treatment virus [DOI] 10.1002/fsn3.2576 PMC 바로가기 [Article Type] Original Research
Invasive Fungal Disease Complicating Coronavirus Disease 2019: When It Rains, It SporesArticle Published on 2021-10-012023-06-18 Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, [키워드] β-D-glucan Aspergillus Candida COVID-associated pulmonary aspergillosis galactomannan [DOI] 10.1093/cid/ciaa1342 PMC 바로가기
A review of significance of Aspergillus detection in airways of ICU COVID-19 patientsICU COVID-19 환자의 기도에서 Aspergillus 검출의 중요성 검토Review Published on 2021-09-012022-09-11 Journal: Mycoses [Category] SARS, 치료기술, [키워드] airway Antifungal treatment Antigen Aspergillus Aspergillus fumigatus Atypical colonisation COVID-19 COVID-19 patient COVID-19 patients criteria Culture decision galactomannan highlight ICU Infection intensive care intensive care unit invasive Invasive pulmonary aspergillosis IPA mechanically ventilated mechanically ventilated patients Mortality mortality. Patient patients with SARS-CoV-2 PCR performed pulmonary aspergillosis radiological receiving risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pneumonia specimen Symptomatology treat Treatment [DOI] 10.1111/myc.13341 PMC 바로가기 [Article Type] Review
Clinical study of invasive pulmonary aspergillosis following influenza A H1N1Article Published on 2021-07-302023-06-23 Journal: Medicine [Category] 신종인플루엔자, [키워드] alveolar lavage fluid anti-Aspergillus treatment galactomannan H1N1 Invasive pulmonary aspergillosis [DOI] 10.1097/MD.0000000000026434 PMC 바로가기
Pervasive but Neglected: A Perspective on COVID-19-Associated Pulmonary Mold Infections Among Mechanically Ventilated COVID-19 PatientsMedicine Published on 2021-06-142022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Aspergillus Fusarium absence Antifungal treatment Aspergillus BAL caused clinical feature Clinical management collected coronavirus disease country COVID-19 COVID-19 patient COVID-19-associated pulmonary mold infections criteria Culture drugs Epidemiological study Factors Fusarium galactomannan highlight Host ICUs Infection intensive care unit mechanically ventilated mechanically ventilated patients mechanically ventilation Mold multicenter Patient patients positive Prevalence prevalent Prospective Study pulmonary radiological recent serum serum sample severely ill patients shown study period the patient treated [DOI] 10.3389/fmed.2021.649675 PMC 바로가기 [Article Type] Medicine