Evaluation of potential aging biomarkers in healthy individuals: telomerase, AGEs, GDF11/15, sirtuin 1, NAD+, NLRP3, DNA/RNA damage, and klothoarticle Published on 2023-07-312024-09-05 Journal: Biogerontology [Category] update2024, [키워드] AGEs aging DNA/RNA damage GDF15 NLRP3 Sirtuin 1 [DOI] 10.1007/s10522-023-10054-x PMC 바로가기 [Article Type] article
Association of GDF15 levels with body mass index and endocrine status in β‐thalassaemiaDiabetes/Lipids/Obesity/Metabolism Published on 2023-02-272024-09-05 Journal: Clinical endocrinology [Category] update2024, [키워드] beta‐thalassaemia body mass index GDF15 IGF 1 [DOI] 10.1111/cen.14897 PMC 바로가기 [Article Type] Diabetes/Lipids/Obesity/Metabolism
GDF15 and ACE2 stratify COVID-19 patients according to severity while ACE2 mutations increase infection susceptibilityGDF15 및 ACE2는 중증도에 따라 COVID-19 환자를 계층화하는 반면 ACE2 돌연변이는 감염 감수성을 증가시킵니다Article Published on 2022-07-222022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 characterized circulating Cohort coronavirus disease coronavirus disease 19 COVID-19 COVID-19 patient disease disease severity Early detection Effect Frequency GDF15 GDF5 global pandemic growth heterogeneous in vitro Infection Inflammation Mild Mild disease Missense Mutation mutations Patient plasma Prognosis risk factor sensitivity severity severity of COVID-19 SNP SNPs susceptibility uninfected control [DOI] 10.3389/fcimb.2022.942951 PMC 바로가기 [Article Type] Article
Gene Networks of Hyperglycemia, Diabetic Complications, and Human Proteins Targeted by SARS-CoV-2: What Is the Molecular Basis for Comorbidity?SARS-CoV-2가 표적으로 하는 고혈당증, 당뇨병 합병증 및 인간 단백질의 유전자 네트워크: 동반 질환의 분자적 근거는 무엇입니까?Article Published on 2022-06-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] ACE2 ANDSystem Angiogenesis applied approach associative Basis Beta beta cell Beta cells bioinformatics Bioinformatics analysis BRD2 Cell Comorbidity Complication complications COMT COVID-19 CTSB CTSL defined degranulation determine diabete diabetes Diabetic diabetic complications disorder DNMT1 DPP4 dysfunction enrichment analysis ERP44 expand F2RL1 GDF15 gene networks Gene ontology General population GPX1 HDAC2 HMOX1 Human HYOU1 hyperglycemia hypoxia IDE identify immune Inflammatory response insulin insulin resistance intracellular protein involved LOX mechanism metabolism molecular basis molecular network network NUTF2 organ damage oxygen pathophysiological patients with diabetes PCNT PLAT Platelet protease Proteins RAB10 reactive oxygen specy reconstructed Regulation RHOA SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 entry receptor SCARB1 SELENOS severe COVID-19 TMPRSS2 Vascular [DOI] 10.3390/ijms23137247 PMC 바로가기 [Article Type] Article
GDF15: an emerging modulator of immunity and a strategy in COVID-19 in association with iron metabolismGDF15: 철 대사와 관련된 COVID-19의 면역 조절제 및 전략Review Published on 2021-11-012022-09-11 Journal: Trends in endocrinology and metabolism: TEM [Category] Coronavirus, SARS, 바이오마커, 신약개발, 치료법, [키워드] ACE2 acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus alteration angiotensin appear association attachment cardiovascular diseases caused contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critically ill Cytokine storm death domain drug therapy ENCODE endothelial envelope enzyme expressed GDF15 growth host cell host cells Immunity increases in iron iron homeostasis Iron metabolism life cycle mediator membrane metabolism multiorgan failure nucleocapsid outcome pandemic Patient patients with COVID-19 progression of disease Proteins provide Receptor-binding domain respiratory distress Respiratory distress syndrome responsible SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 structural protein structural proteins subunit syndrome target TGF-β therapeutic therapy tissue tissue damage Tolerance transforming growth factor vascular dysfunction virus Virus life cycle with COVID-19 [DOI] 10.1016/j.tem.2021.08.011 PMC 바로가기 [Article Type] Review
Comprehensive Profiling of Inflammatory Factors Revealed That Growth Differentiation Factor-15 Is an Indicator of Disease Severity in COVID-19 Patients염증 인자의 포괄적 인 프로파일 링은 성장 분화 인자 -15가 COVID-19 환자의 질병 중증도의 지표임을 보여 주었다.Immunology Published on 2021-07-152022-08-31 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, [키워드] Admission Alanine alanine aminotransferase analyzed aspartate Aspartate aminotransferase Asymptomatic Bioinformatics analysis Biomarker blood cell candidate CD200 change Comprehensive convalescent COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patient COVID-19 patients Critical differentiation discharge disease severity Elevation ELISA eosinophil eosinophil counts expression level expression levels FABP2 Factor functional GDF15 group groups healthy control identify include Indicator inflammatory factors lymphocyte Mild moderate neutrophil neutrophil count NLR Occurrence Patient patient sera Potential biomarker potential biomarkers predict Prevent Profiling progression Remission Revealed severe COVID-19 severe group severity severity of COVID-19 the disease TRAIL Transferrin VCAM-1 were measured White blood cell white blood cell count [DOI] 10.3389/fimmu.2021.662465 PMC 바로가기 [Article Type] Immunology
Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation Research Published on 2021-04-122022-10-05 Journal: Nature metabolism [Category] 바이오마커, 신약개발, [키워드] Activation Anti-inflammatory anti-inflammatory action bind Biomarker block Cell circulating Colchicine disorders dose Efficacy and safety GDF15 growth hepatocyte hepatocytes identity in vivo indirect mechanism induce inflamed tissues Inflammatory inflammatory signalling inhibit liver mechanism mice molecular myeloid cell myeloid cells phosphatase positive PTPN6 receptor recruitment Regulation required reveal Safe secretion selective treat Trigger [DOI] 10.1038/s42255-021-00366-y [Article Type] Research
Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of deathCOVID-19 투석 환자의 종단 단백질 프로파일링은 사망의 중증도 및 예측 인자를 나타냅니다Research Article Published on 2021-03-112022-09-10 Journal: eLife [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] adhesion molecules analyses Biomarkers Blood blood protein blood proteins blood sample CCL2 CCL7 changed circulating Clinical severity Combination correlated COVID-19 COVID-19 patient COVID-19 patients CTSD Cytokines damage death determine dialysis differentially expressed disease disease severity displaying drug end-stage kidney disease epithelial fatal COVID-19 fatal disease GDF15 help high risk hospitalised Human identifying IL18BP IL6 in some increased risk Inflammation Injury innate immune activation integrin Integrins Interaction involved joint kidney Kidney disease Kidney failure KRT19 linear mixed model longitudinal machine-learning marker Mild mild illness monocyte neutrophil neutrophil activation non-hospitalised non-infected Older other diseases pathology Patient patients patients with COVID-19 predict predictor problems profile Protein proteinase Proteins proteomic proteomics recruitment resource reveal severe COVID-19 severe disease severe disease progression severity similarities statistical survival analysis targets These data tissue tissue injury tissues [DOI] 10.7554/eLife.64827 PMC 바로가기 [Article Type] Research Article
Circulating levels of growth differentiation factor 15 and sex hormones in male patients with HBV-associated hepatocellular carcinomaArticle Published on 2020-01-012023-06-13 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] B형 간염, [키워드] GDF15 HBV Hepatocellular carcinoma Sex hormones [DOI] 10.1016/j.biopha.2019.109574