Rapid diagnostic tests for malaria diagnosis in Cameroon: impact of histidine rich protein 2/3 deletions and lactate dehydrogenase gene polymorphismarticle Published on 2024-01-312024-09-01 Journal: Diagnostic Microbiology and Infectious Disease [Category] 말라리아, [키워드] Genetic variations Histidine rich protein 2 and 3 lactate dehydrogenase Plasmodium falciparum Plasmodium ovale curtisi [Article Type] article
Integrative analyses of genes about venous thromboembolism: An umbrella review of systematic reviews and meta-analysesArticle Published on 2022-10-282022-11-16 Journal: Medicine [Category] meta-analysis, 변종, [키워드] activating Analysis appraisal checklist conducted COVID-19 vaccination criteria Critical cumulative database Effect effect size eligible endothelial environmental risk factor Epidemiology estimates etiology Evidence Genetic genetic risk factor Genetic variant Genetic variations had more heterogeneity Human identify Intervention meta-analyses Meta-analysis MTHFR network p values performed polymorphism protease Protein prothrombin provided receptor respond review risk Risk factors Sample size selected surgical systematic review variable variant Venice venous Venous Thromboembolism VTE was performed were used [DOI] 10.1097/MD.0000000000031162 PMC 바로가기
Molecular mechanisms involved in anosmia induced by SARS-CoV-2, with a focus on the transmembrane serine protease TMPRSS2막횡단 세린 프로테아제 TMPRSS2를 중심으로 SARS-CoV-2에 의해 유도된 후각장애와 관련된 분자 기전Review Published on 2022-10-012022-09-11 Journal: Archives of Virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Anosmia Apoptosis blockade camostat caused cell entry cellular and molecular chromosome chromosome 21 cleaving Delta dependent on disease disorder dysfunction entry of SARS-CoV-2 event ExoN exons facilitate functional gene encoding Genetic variations help host cell Inflammation involved mechanism nafamostat neuronal number of symptoms olfactory dysfunction olfactory neuroepithelium omicron overcome pandemic virus receptor receptors risk SARS-CoV-2 Serine serine protease serine protease inhibitor serine protease inhibitors shown strain Strains Symptoms therapeutic TMPRSS2 transmembrane serine protease viral S protein virus [DOI] 10.1007/s00705-022-05545-0 PMC 바로가기 [Article Type] Review
Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll-like receptors dictates pathophysiology of COVID-19 disease주로 전염증성 사이토카인, 사이토카인 수용체 및 톨 유사 수용체의 개별 유전적 다양성이 COVID-19 질병의 병태생리를 좌우합니다Review Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] acquired immunity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alter B cells chemokine chemokines Clinical outcome clinical outcomes coding gene coding genes condition coronavirus coronavirus disease Coronavirus disease-19 Coronavirus-2 COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 severity cytokine Cytokine storm Cytokines determine exacerbate Gene Expression genes encoding Genetic genetic variability Genetic variation Genetic variations Host IL10 IL17 IL4 IL6 IL7 immune immune response immune responses Immunity individual Infection Inflammation Innate interferons Monocytes Mutation natural killer cell Natural killer cells Neutrophils nucleotide pathophysiology Patient polymorphism proinflammatory cytokines receptors respiratory symptoms response SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe respiratory symptoms severity of COVID-19 Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs susceptibility T cells the patient TLR TLR3 TLR7 TLR9 TLRs TNF Toll-like receptor Toll-like receptors understanding variants of concern Variation viral infection viral infections VOCs [DOI] 10.1002/jmv.27849 PMC 바로가기 [Article Type] Review
Serine Protease Inhibitors Restrict Host Susceptibility to SARS-CoV-2 Infections세린 프로테아제 억제제는 SARS-CoV-2 감염에 대한 숙주 감수성을 제한합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] A1AT acute respiratory syndrome Administered Affect affecting age Alpha alpha-1-antitrypsin antithrombin III antitrypsin Antiviral antiviral drug antiviral intervention approach asymptomatic infection asymptomatic infections ATIII can be used cellular cellular protease ciliated cleavage club Comorbidities Comorbidity complex coronavirus disease Coronavirus disease 2019 COVID-19 deficiency determinant determinants disease disease severity Donor door expression expression level Factor Genetic Genetic variation Genetic variations goblet cells highlight Host human donors identification identify identity immune response individual Infection inhibitor inhibitors less lung cell mechanism mechanism of action outcome PAI1 Patient patients plasminogen activator inhibitor 1 Potential potential treatments primary cell primary cells reduce reducing regulate restrict risk risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 susceptibility Serine serine protease serine protease inhibitor serine protease inhibitors serpin serpin. SERPINA1 SERPINE1 SERPINE2 serpins Severe acute respiratory syndrome severe COVID-19 severe infections Sex Single-cell RNA sequencing Spike protein susceptibility susceptible Symptom target cells TMPRSS2 Treatment Usage Variation viral burden viral entry viral spike protein [DOI] 10.1128/mbio.00892-22 PMC 바로가기 [Article Type] Article
Identification, propagation and molecular characterization of SARS-CoV-2 delta variant isolated from Egyptian COVID-19 patients이집트 COVID-19 환자에서 분리된 SARS-CoV-2 델타 변이체의 식별, 전파 및 분자 특성 분석Article Published on 2022-06-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition applied B.1.617.2 beta-propiolactone causative agent cell line cell lines characterized China city clade clinically collected continuous monitoring coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient CPE Cytopathic effect Delta delta variant diagnosed with COVID-19 effective Effectiveness Efficacy Genetic genetic mutation Genetic variations genome sequence Genome sequences genomic sequence identification inactivated Isolation molecular Mutation rates nasopharyngeal swabs pandemic passage Patient PCR Prevalence Propagation provide qPCR reference strain Replication researcher RT-qPCR SARS-CoV-2 SARS-CoV-2 delta sequence severe acute respiratory syndrome Coronavirus Spread Swab the SARS-CoV-2 transmission rate Treatment protocol Vaccine variant variant of concern variants of concern Variation Vero E6 Vero E6 cell VERO E6 cells viral genome virus VoC was performed WGS whole genome Whole genome sequencing Wuhan-Hu-1 [DOI] 10.1016/j.meegid.2022.105278 PMC 바로가기 [Article Type] Article
Association of tumor necrosis factor alpha -308 single nucleotide polymorphism with SARS CoV-2 infection in an Iraqi Kurdish population이라크 쿠르드족 인구에서 SARS CoV-2 감염과 종양 괴사 인자 알파 -308 단일 염기 다형성의 연관성Article Published on 2022-05-012022-09-11 Journal: Journal of Clinical Laboratory Analysis [Category] 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha association caused coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 infections COVID-19 patients expression General population Genetic variations Genotype genotyping heterozygous homozygous immune dysregulation increase Infection infections Infectious disease Infectious diseases innate immune gene innate immune genes Iraq mutant Necrosis organ damage p value Patient patients polymerase chain reaction polymorphism Population promoter region Protein risk factor Risk factors Sample size SARS CoV SARS CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severity significantly single nucleotide single-nucleotide single-nucleotide polymorphism SNP the disease TNF TNF- 308 TNF-α Tumor tumor necrosis tumor necrosis factor Variation was used [DOI] 10.1002/jcla.24400 PMC 바로가기 [Article Type] Article
Consecutive deletions in a unique Uruguayan SARS-CoV-2 lineage evidence the genetic variability potential of accessory genes독특한 우루과이 SARS-COV-2 계보의 연속 결실Research Article Published on 2022-02-172022-09-10 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] accessory gene Accessory genes Amino acid amino acids B.1.1.33 capillary electrophoresis changes changes in clade collected Complete Deletion deletions downstream Evidence function fused fused protein genetic variability Genetic variation Genetic variations Genome genomic help Illumina include individual Lineage Next-generation sequencing nucleotide nucleotides occur Occurrence ORF ORF7a ORF7b peptide promote Protein Sanger sequencing SARS-CoV-2 SARS-CoV-2 lineage signal peptide the early SARS-CoV-2 the signal peptide transmembrane domain transmembrane protein unique virus [DOI] 10.1371/journal.pone.0263563 PMC 바로가기 [Article Type] Research Article
Genetic variations from successive whole genome sequencing during COVID-19 treatment in five individualsCorrespondence Published on 2022-01-012022-10-05 Journal: New Microbes and New Infections [Category] 변종, 치료법, [키워드] Affect binding binding affinity COVID-19 Favipiravir FIVE Genetic variations increase individual Mutation next generation sequencing ORF1b polymorphism Remdesivir SARS-CoV-2 Sequencing shown single nucleotide Treatment Variation whole genome [DOI] 10.1016/j.nmni.2022.100950 [Article Type] Correspondence
Multi‐omics of the expression and clinical outcomes of TMPRSS2 in human various cancers: A potential therapeutic target for COVID‐19인간의 다양한 암에서 TMPRSS2의 발현 및 임상 결과의 멀티오믹스: COVID-19의 잠재적 치료 표적Original Article Published on 2021-12-242022-09-10 Journal: Journal of Cellular and Molecular Medicine [Category] MERS, 바이오마커, [키워드] TMPRSS2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed Analysis bioinformatics Biomarker Blood Brain Breast Cancer cancer progression cancers clinical consequence clinical consequences Clinical outcome Colorectal cancer contribute coronavirus coronavirus disease correlated correlation COVID‐19 DEGs effective Evidence expressed gene expression Genes Genetic variations humans Immune cell infiltration immune infiltration incidence Infection lung molecular multi‐omics analysis network analysis outbreak ovarian Pathway analysis Pathways Patient potential therapeutic target Prevent Prognosis prognostic prognostic analysis Prognostic biomarkers Prognostic value progression Protein regulate respiratory Respiratory system SARS‐CoV‐2 SARS‐CoV‐2 infection severe acute respiratory syndrome Coronavirus shown significantly Soft tissue therapeutic target tissue tissues TMPRSS2 transmembrane serine protease transmembrane serine protease 2 Tumours [DOI] 10.1111/jcmm.17090 PMC 바로가기 [Article Type] Original Article