Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19COVID-19의 적응 면역 구획 전반에 걸친 항원 수용체 레퍼토리 파괴의 글로벌 패턴Article Published on 2022-08-232022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 치료기술, [키워드] adaptive adaptive immune responses aligned anticipated Antigen antigen-receptor repertoires applied approach B cell Cluster COVID-19 deficiency disease disease severity enrichment genomic Genomic DNA IGH immune immune responses Immunoglobulin immunoPETE individuals Infectious disease loci Next-generation sequencing occurred Older pathogen pathogen-specific Patient primary focus receptor reducing risk factor SARS-CoV-2 sequence Seroconversion T cell T cell receptor T cells TCR variant vulnerability [DOI] 10.1073/pnas.2201541119 PMC 바로가기 [Article Type] Article
Electrochemical Biosensor for Sensitive Detection of Hepatitis B in Human PlasmaArticle Published on 2022-06-012023-06-12 Journal: Applied biochemistry and biotechnology [Category] B형 간염, [키워드] electrochemical biosensor Genomic DNA Hepatitis B virus Poly(4-AMP). [DOI] 10.1007/s12010-022-03829-4
A Simple and Universal Nucleic Acid Assay Platform Based on Personal Glucose Meter Using SARS-CoV-2 N Gene as the ModelSARS-CoV-2 N 유전자를 모델로 사용하는 개인 혈당 측정기를 기반으로 하는 간단하고 보편적인 핵산 분석 플랫폼Article Published on 2022-04-152022-09-11 Journal: Biosensors [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acid complement convert COVID-19 Diagnosis diagnostic disease-associated early diagnosis expected Genomic DNA Glucose in vitro in vitro detection Intervention limit of detection magnetic bead Meter Model nucleic acid nucleic acid assay outbreak Personal glucose meter platform point-of-care Quantitative resource Saliva SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 N selective sequence serum samples simple stability suspected patient suspected patients Universal [DOI] 10.3390/bios12040249 PMC 바로가기 [Article Type] Article
Alterations in the oral microbiome of individuals with a healthy oral environment following COVID-19 vaccinationCovid-19 백신 접종 후 건강한 구강 환경을 가진 개인의 구강 미생물 군집의 변화Research Published on 2022-03-032022-09-01 Journal: BMC Oral Health [Category] Fulltext, MERS, SARS, 진단, [키워드] 16S rRNA 16S rRNA gene acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Affect Alter alteration analyzed Bacterial Bacteroide coronavirus coronavirus disease COVID-19 COVID-19 vaccination digestive system DNA Ecology Effect Efficacy examined Genomic DNA Health healthcare personnel healthy Healthy oral environment individual insight intestinal Japanese microbial Microbiome mRNA vaccination mRNA vaccine Next-generation sequencing oral health Oral microbiome PCR amplicon PCR amplicons proportion recruited respiratory Result rRNA Saliva saliva samples SARS-CoV-2 severe acute respiratory syndrome Coronavirus severity significantly significantly increased vaccination Vaccine vaccine efficacy was collected were assessed [DOI] 10.1186/s12903-022-02093-6 PMC 바로가기 [Article Type] Research
ACE and ACE2 Gene Variants Are Associated With Severe Outcomes of COVID-19 in MenACE 및 ACE2 유전자 변이는 남성의 심각한 COVID-19 결과와 관련이 있습니다Immunology Published on 2022-02-172022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] 95%CI ACE ACE2 ACE2 gene acute respiratory syndrome acute respiratory syndrome coronavirus addition adjusted affecting age association clinical manifestation clinical manifestations Clinical manifestations of COVID-19 coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 Critical Critical illness death develop diabetes diagnosed died disease severity DNA evaluated explain Factor genetic background Genetic variant genetic variants Genomic DNA Genotype genotyped High-resolution Host hypertension IMPROVE individual insertion/deletion involved Logistic regression analysis male men Mild obesity Odds ratio outcome outcomes oxygen oxygen supplementation pandemic Peripheral blood polymorphism Polymorphisms probes respiratory respond responsible reverse transcription PCR risk factor rs2285666 RT-PCR Saliva SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity severity of COVID-19 Sex single-nucleotide single-nucleotide polymorphism SNP study population T allele TaqMan type 2 diabetes Variability variant [DOI] 10.3389/fimmu.2022.812940 PMC 바로가기 [Article Type] Immunology
Are angiotensin converting enzyme (ACE1/ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A single-center cohort study안지오텐신 전환 효소(ACE1/ACE2) 유전자 변이가 COVID-19 폐렴의 임상 중증도와 관련이 있습니까? 단일 센터 코호트 연구Article Published on 2022-02-012022-09-11 Journal: Anatolian journal of cardiology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] abnormality ACE ACE gene ACE1 ACE1 gene ACE1/ACE2 ACE2 ACE2 gene Admission age allele Analysis angiotensin angiotensin converting enzyme automated Bioinformatics analysis Clinical characteristics Clinical severity Cohort cohort study coronavirus disease Coronavirus disease 2019 COVID-19 determine disease severity DNA domain DSP enzyme exon 1 frequencies Frequency functional Genetic Genomic DNA Genotype group I/D polymorphism ICU independent predictor independent predictors intensive care intensive care unit investigated knowledge no effect non-ICU Older age other variant pandemic Patient patients hospitalized Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes Pneumonia polymorphism Polymorphisms purified radiologic recent Sanger sequencing Science Sequencing analysis severe disease single-center statistical analysis Statistical Package variant was performed was used [DOI] 10.5152/AnatolJCardiol.2021.502 PMC 바로가기 [Article Type] Article
Fabrication of Wearable PDMS Device for Rapid Detection of Nucleic Acids via Recombinase Polymerase Amplification Operated by Human Body HeatArticle Published on 2022-01-272022-10-27 Journal: Biosensors [Category] COVID-19, [키워드] acid amplification amplify applied Body body heat condition conducted Contact coronavirus disease COVID-19 detection Device DNA DNA amplification DNA plasmid E. coli Escherichia coli fabrication gel electrophoresis Genomic DNA heat Human human body heat IMPROVE limit of detection Modification nucleic acid amplification pandemic Plasmid poly(dimethylsiloxane) (PDMS) polymerase Rapid REcombinase Recombinase polymerase amplification (RPA) RPA SARS-CoV-2 Support temperature wearable RPA microdevice [DOI] 10.3390/bios12020072 PMC 바로가기 [Article Type] Article
Fabrication of Wearable PDMS Device for Rapid Detection of Nucleic Acids via Recombinase Polymerase Amplification Operated by Human Body HeatArticle Published on 2022-01-272022-10-27 Journal: Biosensors [Category] Coronavirus, COVID-19, SARS, [키워드] acid amplification amplify applied Body body heat condition conducted Contact coronavirus disease COVID-19 detection Device DNA DNA amplification DNA plasmid E. coli Escherichia coli fabrication gel electrophoresis Genomic DNA heat Human human body heat IMPROVE limit of detection Modification nucleic acid amplification pandemic Plasmid poly(dimethylsiloxane) (PDMS) polymerase Rapid REcombinase Recombinase polymerase amplification (RPA) RPA SARS-CoV-2 Support temperature wearable RPA microdevice [DOI] 10.3390/bios12020072 PMC 바로가기 [Article Type] Article
eccDNAs are apoptotic products with high innate immunostimulatory activity Research Published on 2021-10-222022-10-05 Journal: Nature [Category] 유전자 메커니즘, [키워드] Apoptosis apoptotic biogenesis clinical implication cytosolic demonstrated dependent on described DNA DNA fragmentation element full-length function Genome Genomic DNA immune response immunostimulant immunostimulatory independent inducer mechanism nanopore sequencing pathway purified random sequence sequenced STING [DOI] 10.1038/s41586-021-04009-w [Article Type] Research
Using Cy5-dUTP labelling of RPA-amplicons with downstream microarray analysis for the detection of antibiotic resistance genesArticle Published on 2021-10-112022-10-04 Journal: Scientific Reports [Category] 진단, [키워드] amplicons amplification antibiotic resistance gene Biological techniques Cell detect diagnostics Disadvantages downstream dTTP Escherichia coli flexible Genes Genomic DNA isothermal isothermal amplification method less microarray analysis Molecular biology overcome pathogen performed point of care primer Primers probe provide RPA sensitivity Target genes [DOI] 10.1038/s41598-021-99774-z PMC 바로가기 [Article Type] Article