helper – Communicable Diseases Research

T Cells in Multisystem Inflammatory Syndrome in Children (MIS-C) Have a Predominant CD4+ T Helper Response to SARS-CoV-2 Peptides and Numerous Virus-Specific CD4- CD8- Double-Negative T Cells

소아 다기관 염증 증후군(MIS-C)의 T 세포는 SARS-CoV-2 펩티드 및 수많은 바이러스 특이적 CD4-CD8- 이중 음성 T 세포에 대한 CD4+ T 도우미 반응이 우세합니다.

Article

Published on 2022-06-292022-09-11
Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술,

Helminth antigens differentially modulate the activation of CD4 + and CD8 + T lymphocytes of convalescent COVID-19 patients in vitro

기생충 항원은 시험관 내에서 회복기 COVID-19 환자의 CD4 + 및 CD8 + T 림프구의 활성화를 차등적으로 조절합니다

Article

Published on 2022-06-282022-09-11
Journal: BMC Medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] Activation activation markers. addition African age analyzed Antigen antigens Ascaris lumbricoides Brugia malayi caused CD137 CD137 (4-1BB) CD4 CD4+ CD4+ helper and CD8+ T cytotoxic T cells CD69 CD8 CD8+ cell culture supernatants cell-mediated immune response convalescent COVID-19 patient coronavirus coronavirus disease Coronavirus disease 2019 country Course COVID-19 COVID-19 patient COVID-19 patients cytokine expression Cytotoxic T cell Cytotoxic T cells death Disease progression Effect Endemic evade expression Factors flow cytometry Frequency genetics helminth Helminth antigens helper human immune response Hypothesis IFN-γ IFNγ IL-10 IL-6 immune immune reactivity immune responses in vitro incidence of COVID-19 investigated mechanisms moderate modulate MONITOR Mortality not affected offer Onchocerca volvulus pandemic parasites PBMC PBMCs peptides Prevalence reactivity reduced reduction remained Respiratory disease SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 transmission significantly significantly increased Spread Stimulation sub-Saharan Africa Support suppress T cell T cell response T cells T helper cells T lymphocyte TNFα Vaccines virus was measured were used
[DOI] 10.1186/s12916-022-02441-x PMC 바로가기 [Article Type] Article

Potential Immunogenic Activity of Computationally Designed mRNA- and Peptide-Based Prophylactic Vaccines against MERS, SARS-CoV, and SARS-CoV-2: A Reverse Vaccinology Approach

MERS, SARS-CoV 및 SARS-CoV-2에 대한 계산적으로 설계된 mRNA 및 펩티드 기반 예방 백신의 잠재적 면역원 활성: 역백신학 접근

Article

Published on 2022-04-062022-09-11
Journal: Molecules [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] 3D structure activity acute respiratory syndrome coronavirus antiviral therapeutics B-cells binding coronavirus Coronavirus-2 Coronaviruses cross-protective CTL CTLs cytotoxic cytotoxic T lymphocytes develop effective Efficacy epitope Epitope-based vaccine Epitopes evaluated followed by HCoVs helper highly pathogenic HTL epitope HTL epitopes HTLs human coronavirus human coronaviruses humans Immune simulation immunogenic immunogenic activity imperative lethality MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus molecular docking mRNA mRNA-based offer pandemic pathogenic coronaviruses peptide Potential predicted processed Prophylactic prophylactic vaccine. proteomic RBDs receptor-binding domains respiratory respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 similarity the receptor-binding domain these viruses TLR4 Vaccine Vaccine design viruses
[DOI] 10.3390/molecules27072375 PMC 바로가기 [Article Type] Article

The Humoral Immune Response to BNT162b2 Vaccine Is Associated With Circulating CD19+ B Lymphocytes and the Naïve CD45RA to Memory CD45RO CD4+ T Helper Cells Ratio in Hemodialysis Patients and Kidney Transplant Recipients

Immunology

Published on 2021-12-032022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, SARS,

[키워드] alteration analyzed anti-SARS-CoV2 antibodies antibody production Antibody Response Antibody titer association B cell B cells B lymphocyte baseline BNT162b2 CD19+ CD19+ B lymphocytes CD4+ CD45RA CD45RO Cellular immune response circulating correlation dose first dose flow cytometry fraction helper Hemodialysis humoral Immunosuppressed in both group in both groups kidney transplant recipient kidney transplant recipients lymphocyte material memory memory CD4+CD45RO+ T helper cells naïve CD4+CD45RA+ T helper cells naïve Patient positive correlation provide Ratio recipient response Result SARS-CoV-2 vaccination SARS-CoV2 second dose seronegative seropositive subpopulation T cell T helper cell Transplant vaccination vaccination efficacy vaccine dose vaccine-induced antibody response
[DOI] 10.3389/fimmu.2021.760249 PMC 바로가기 [Article Type] Immunology

Follicular Helper T Cells in the Immunopathogenesis of SARS-CoV-2 Infection

SARS-CoV-2 감염의 면역병인 발생에서 여포 도우미 T 세포

Review

Published on 2021-09-162022-09-12
Journal: Frontiers in Immunology [Category] SARS, 진단,

Functional responsiveness of memory T cells from COVID-19 patients

COVID-19 환자의 기억 T 세포의 기능적 반응성

Article

Published on 2021-07-012022-09-12
Journal: Cellular immunology [Category] MERS, SARS, 진단,

Clonal analysis of immunodominance and cross-reactivity of the CD4 T cell response to SARS-CoV-2

SARS-CoV-2에 대한 CD4 T 세포 반응의 면역우세 및 교차 반응성의 클론 분석

Report

Published on 2021-05-182022-09-10
Journal: Science (New York, N.y.) [Category] MERS, SARS, 변종, 치료법,

Hemagglutinin Functionalized Liposomal Vaccines Enhance Germinal Center and Follicular Helper T Cell Immunity

헤마글루티닌 기능화 리포솜 백신은 배아 중심 및 여포 도우미 T 세포 면역을 강화합니다

Article

Published on 2021-05-012022-09-12
Journal: Advanced Healthcare Materials [Category] SARS, 진단,

Monitoring peripheral neutrophil and T-lymphocyte subsets could assist in differentiating the severity and disease progression of coronavirus disease 2019

말초 호중구 및 T-림프구 하위 집합을 모니터링하면 코로나바이러스 질병 2019의 중증도와 질병 진행을 구별하는 데 도움이 될 수 있습니다

Research Paper

Published on 2021-03-312022-09-10
Journal: Aging (Albany NY) [Category] SARS, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission Analysis analyzed Antiviral assist AUC baseline CD3+ CD3+CD4+ CD3+CD4+ T cells CD3+CD8+ CD4+ CD4+ T lymphocyte CD8+ T cells center characteristic clinical Clinical significance clinician coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Cytotoxic T cell Cytotoxic T cells disease Disease progression evaluate expression help helper helper T cells lymphocyte Lymphocytes monitoring neutrophil neutrophil to CD4+ T lymphocyte ratio/N4R NK cell NK cells patients with COVID-19 peripheral lymphocyte Potential biomarker potential biomarkers progression Public receiver operating characteristic respiratory SARS-CoV-2 SARS-CoV-2 RNA detection severe acute respiratory syndrome Coronavirus severity subset T cell T cells T lymphocyte T-cell test negative therapy
[DOI] 10.18632/aging.202701 PMC 바로가기 [Article Type] Research Paper

Clonal expansion and activation of tissue-resident memory-like T H 17 cells expressing GM-CSF in the lungs of patients with severe COVID-19

중증 COVID-19 환자의 폐에서 GM-CSF를 발현하는 조직 상주 기억 유사 T H 17 세포의 클론 확장 및 활성화

Research Article

Published on 2021-02-232022-09-12
Journal: Science Immunology [Category] Fulltext, MERS, 진단,

[키워드] Activation acute respiratory distress acute respiratory distress syndrome Analysis Autoimmune diseases Bacterial bacterial pneumonia BAL Blood Bronchoalveolar lavage Bronchoalveolar lavage fluid CD8 Cell cell type cells cellular characterized Clinical course clonal expansion clone Cohort cohort of patient collected contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pneumonia CSF2 cytokine cytokine expression profile disease severity elevated expressing feature Generation GM-CSF helper high mortality hyperinflammation identify IL-17A IL17A Immune cell immune cell type immune cells immune response Immunopathogenesis interactome investigated involved lung lung damage Lung injury Lung pathology lung tissue Lungs Macrophage macrophages mechanism memory T cell moderate disease pathogenic Patient patients with COVID-19 Pneumonia protein level pulmonary T respiratory distress Respiratory distress syndrome serum severe coronavirus disease severe COVID-19 Severe COVID-19 pneumonia single-cell subsequent syndrome T cell T cell response T cells T helper TCR Th17 cells Therapies tissues Transcriptome Viral viral clearance viral infection
[DOI] 10.1126/sciimmunol.abf6692 PMC 바로가기 [Article Type] Research Article