Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mouse hepatocytesarticle Published on 2024-07-042024-09-05 Journal: Toxicological sciences : an official journal of th [Category] update2024, [키워드] (PPARα) hepatocytes HFPO-DA (GenX) mode of action (MOA) peroxisome proliferator-activated receptor α PFAS transcriptomics [DOI] 10.1093/toxsci/kfae045 PMC 바로가기 [Article Type] article
A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytesResearch Article Published on 2024-02-282024-09-05 Journal: Protein & Cell [Category] update2024, [키워드] aging hepatocytes liver senescence single-nucleus RNA sequencing SREBP2 [DOI] 10.1093/procel/pwad039 PMC 바로가기 [Article Type] Research Article
Hepatitis B virus-related intrahepatic cholangiocarcinoma originates from hepatocytesarticle Published on 2023-06-272024-09-05 Journal: Hepatology international [Category] update2024, [키워드] HBV hepatocytes Intrahepatic cholangiocarcinoma (ICC) organoids [DOI] 10.1007/s12072-023-10556-3 PMC 바로가기 [Article Type] article
Cell atlas of CCl 4 -induced progressive liver fibrosis reveals stage-specific responsesArticle Published on 2023-05-182024-09-05 Journal: Zoological research [Category] update2024, [키워드] Angiogenesis cell-cell interactions Gene regulatory networks Hepatic stellate cells hepatocytes Liver fibrosis Single-cell and single-nucleus RNA-sequencing Toxicity [DOI] 10.24272/j.issn.2095-8137.2023.031 PMC 바로가기 [Article Type] Article
Replication and Injury Associated With SARS-CoV-2 in Cultured HepatocytesResearch Article Published on 2023-02-122024-09-05 Journal: Pathogens and Immunity [Category] update2024, [키워드] Apoptosis COVID hepatocytes liver Remdesivir Replication SARS-CoV-2 [DOI] 10.20411/pai.v8i2.648 PMC 바로가기 [Article Type] Research Article
HIV DNA persists in hepatocytes in people with HIV-hepatitis B co-infection on antiretroviral therapyArticle Published on 2023-01-012023-06-12 Journal: EBioMedicine [Category] B형 간염, Fulltext, [키워드] hepatocytes HIV reservoir HIV-HBV co-infection Liver Biopsy [DOI] 10.1016/j.ebiom.2022.104391 PMC 바로가기
Dual-Luciferase-Based Fast and Sensitive Detection of Malaria Hypnozoites for the Discovery of Anti-relapse Compoundsarticle Published on 2022-12-312024-09-01 Journal: Methods in molecular biology (Clifton, N.J.) [Category] 말라리아, [키워드] Bioluminescence (BL) Drug screening dual firefly luciferase hepatocytes Hypnozoites liver liver stages malaria monkeys NanoLuc Plasmodium cynomolgi Sporozoites [Article Type] article
Insights on the antiviral mechanisms of action of the TLR1/2 agonist Pam3CSK4 in hepatitis B virus (HBV)-infected hepatocytesArticle Published on 2022-10-012023-06-12 Journal: Antiviral Research [Category] B형 간염, [키워드] antiviral activity FEN-1 Hepatitis B virus hepatocytes NF-κB pathway TLR2 agonist Toll-like receptor 1/2. [DOI] 10.1016/j.antiviral.2022.105386
The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes Research Published on 2022-08-172022-10-05 Journal: Communications Biology [Category] SARS, 치료제, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme-2 attenuate cause coronavirus COVID-19 COVID-19 patients cytopathic effects Deprivation Evidence exacerbated expressed expressing Fatty liver full-length Glycolysis hACE2 hepatic dysfunction hepatocyte hepatocytes Human humanized hyperglycemia immune response include increase Infection infection with SARS-CoV-2 Inflammation inhibition Injury metformin methionine mice mitochondrial Multi-organ damage Patient promote pseudotyped viral particles pseudovirus RBD Receptor binding domain reduce renin-angiotensin system SARS-CoV-2 steatosis susceptibility susceptible therapeutic option Toxicity type 2 diabete viral particle [DOI] 10.1038/s42003-022-03789-9 [Article Type] Research
Direct type I interferon signaling in hepatocytes controls malariaArticle Published on 2022-07-192024-08-29 Journal: Cell Reports [Category] 말라리아, [키워드] cell-intrinsic immunity CP: Immunology CP: Microbiology CRE CRISPR-Cas9 hepatocytes liver liver-stage malaria Plasmodium Sporozoites type I interferons