Heterocyclic scaffolds

[키워드] 2019-nCoV-2, 2019-novel coronavirus 3CLpro, 3chymotrypsin-like protease 9-O-SIA, 9-O-acetyl-N-acetylneuraminic acid ACE2, angiotensin converting enzyme 2 COMFA, Comparative molecular field analysis COMSIA, Comparative molecular similarity indices analysis Coronaviruses COVID 19, Corona virus disease 2019 CPE, Cytopathic effect inhibition assay CRFK cells, Confluent crandel feline kidney cells CVB3 3Cpro, Coxsackievirus B 3 cysteine protease Dabcyl-KTSAVLQSGFRKME-Edans, Dabcyl-Lys-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-Lys-Met-GluEdans, [4-(4-dimethylaminophenylazo) benzoic acid]-KTSAVLQSGFRKME-[5-[2′-(aminoethyl)amino]-naphthalen DTT, 1,4-Dithio-d,l-threitol E protein, envelope protein FDA, Food and Drug Administration FIPV, feline infectious peritonitis virus FRET analysis, Fluorescence resonance energy transfer analysis HBTU, Hexafluorophosphate benzotriazole tetramethyluronium Heterocyclic scaffolds M protein, membrane protein MD simulation, Molecular dynamics simulation MERS MERS CoV, Middle east respiratory syndrome corona virus MM-GBSA, Molecular Mechanics/Generalized Born Surface Area MM-PBSA, Molecular mechanics Poisson–Boltzmann surface area Mpro, Main protease MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide N protein, nucleocapsid protein NFkB, nuclear factor kappa-light-chain-enhancer of activated B cells NIH (MLPCN) screening, National Institutes of Health (Molecular libraries probe production centers network) screening nsp10, non-structural protein 10 nsp12, non-structural protein 12, RNA dependent RNA polymerase nsp13, non-structural protein 13, helicase nsp14, non-structural protein 14, N-terminal exoribonuclease and C-terminal guanine-N7 methyl transferase nsp15, non-structural protein 15, uridylate-specific endoribonuclease nsp16, non-structural protein 16, 2′-O-methyl transferase NTD, N-terminal domain ORFs, open reading frames pandemic PC 3Cpro, Picornavirus 3 cysteine protease PDB, Protein Data Bank PHEIC, Public Health Emergency of International Concern PLpro, papain-like protease PP1a, Polyprotein1a PP1ab, Polyprotein1b qRT-PCR, Quantitative reverse transcription polymerase chain reaction QSAR, Quantitative structure-activity relationship RASPD, Rapid Screening with Physicochemical Descriptors RdRp, RNA dependent RNA polymerase S protein, spike protein SARS CoV SARS CoV-2 SARS CoV, Severe acute respiratory syndrome corona virus WHO, World Health Organisation Z-RLRGG-AMC, Z-Arg-Leu-Arg-Gly-Gly-7-amido-4-methylcoumarin
[DOI] 10.1016/j.bioorg.2020.104315 PMC 바로가기 [Article Type] Review