Host Genetic Background Influences BCG-Induced Antibodies Cross-Reactive to SARS-CoV-2 Spike ProteinCommunication Published on 2024-02-262024-09-05 Journal: Vaccines [Category] update2024, [키워드] BCG cross reactive antibodies Diversity Outbred genetic background heterologous immunity Humoral immunity SARS-CoV-2 [DOI] 10.3390/vaccines12030242 PMC 바로가기 [Article Type] Communication
Bystander activation of Bordetella pertussis-induced nasal tissue-resident memory CD4 T cells confers heterologous immunity to Klebsiella pneumoniaearticle Published on 2023-05-312024-09-01 Journal: Neurogastroenterology and motility : the official [Category] 백일해, [키워드] bacterial immunity Bordetella pertussis heterologous immunity tissue-resident memory T cells Vaccines [Article Type] article
Heterologous immunity induced by 1st generation COVID-19 vaccines and its role in developing a pan-coronavirus vaccineArticle Published on 2022-08-152022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] acute respiratory syndrome adaptive addition COVID-19 COVID-19 pandemic COVID-19 vaccine cross-reactive develop Evolution Heterologous heterologous immunity highlight Hospitalization illnesses Immunity immunization individual Infection mechanism Mortality MOST mutated mutated variant other coronaviruses pan-coronavirus vaccine pandemic Prevent PROTECT protective role Protein SARS-CoV-2 SARS-CoV-2 antigens T cell the Spike understanding universal vaccine development. Vaccine Vaccine development variant viral strains virulent virus strain [DOI] 10.3389/fimmu.2022.952229 PMC 바로가기
Broadly recognized, cross-reactive SARS-CoV-2 CD4 T cell epitopes are highly conserved across human coronaviruses and presented by common HLA alleles널리 알려진 교차 반응성 SARS-CoV-2 CD4 T 세포 에피토프는 인간 코로나바이러스 전반에 걸쳐 고도로 보존되어 있으며 일반적인 HLA 대립유전자에 의해 제시됩니다Article Published on 2022-06-142022-09-12 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Affect animal coronavirus binding CD4 CD4 T cell CD4 T cells common-cold conserved Contact convalescent COVID-19 CP: Immunology CP: Microbiology cross-reactive cross-reactivity Donor donors driven by epitope explained fusion peptide Heterologous heterologous immunity highlight HLA allele homology human coronavirus human populations Infection major histocompatibility complex memory response MHC class mRNA vaccine overlapping preference Protein proximal raise recipients residue SARS-CoV-2 SARS-CoV-2 sequence seasonal coronavirus spike fusion peptide proximal region. Substitution T cell T cell epitope T cell receptor T cell receptor repertoire T cell response TCR TCR sequencing TCRs uninfected [DOI] 10.1016/j.celrep.2022.110952 PMC 바로가기 [Article Type] Article
Differential immunogenicity of homologous versus heterologous boost in Ad26.COV2.S vaccine recipientsAd26.COV2.S 백신 수용자에서 동종 대 이종 부스트의 차등 면역원성Article Published on 2022-02-112022-09-11 Journal: Med (New York, N.Y.) [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Ad26 Ad26.COV2.S Ad26.COV2.S vaccine Adenovirus Adenovirus Vector Antiviral antiviral immunity BNT162b2 boost breadth cellular immune responses cellular immunity ChAdOx1 ChAdOx1 nCoV-19 college coronavirus disease Coronavirus disease 2019 COV2.S COVID-19 dose ENhance feature Heterologous heterologous immunity heterologous vaccine homologous homologous or heterologous humoral immune responses immunological immunological parameter individual individuals knowledge lack Medical Research Council Ministry of Health mRNA of BNT162b2 offered protection pump quantity recipient second dose Singapore single dose small sample size SMD specific antibodies spike-specific antibodies Spike-specific antibody Support supported T cell T cells Trustee utilization vaccination Vaccine Vaccines [DOI] 10.1016/j.medj.2021.12.004 PMC 바로가기 [Article Type] Article
Heterologous Immunity Between SARS-CoV-2 and Pathogenic BacteriaImmunology Published on 2022-01-272022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] Activation acute respiratory syndrome Asymptomatic Bacterial bacterial pathogen bystander CD69 Cell co-culture coronavirus coronavirus disease COVID-19 cross-reactive cross-reactivity cytokine production Donor Effect elicited explain extension Heterologous heterologous immunity high variability IFN-γ IL-2 Immunity in silico in vitro individual induce mechanism memory T memory T cell non-structural protein offered outcome outcomes pathogen pathogenic bacteria peptide peptides proliferation recall recognize response SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 vaccination SARS-CoV-2 vaccine sequence homology severity Spike protein T cell T cell response tested the SARS-CoV-2 the spike protein TNF vaccination [DOI] 10.3389/fimmu.2022.821595 PMC 바로가기 [Article Type] Immunology
Safety and Seroconversion of Immunotherapies against SARS-CoV-2 Infection: A Systematic Review and Meta-Analysis of Clinical TrialsSystematic Review Published on 2021-11-242022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] 95% CI active immunity acute respiratory syndrome adverse event AEs Analysis Antibody Response clinical clinical trial clinical trials components conducted Controlled Coronavirus disease 2019 (COVID-19) Coronavirus-2 defined Efficacy enrolled evaluate healthy Heterologous heterologous immunity host immunity immune response Immunity immunological Immunotherapy inactivated Infection injected inoculated Intervention involved mechanism meta-analyses Meta-analysis neutralize Odds ratio participant passive immunity populations pre-vaccination Prophylactic Protein random-effect Registered review RNA Safety SARS-CoV-2 searched sera Seroconversion severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) systemic adverse event systemic AE therapeutic Treatment Trial trials vaccination Vaccine Vaccines Viral vector viral vector-based virus was used [DOI] 10.3390/pathogens10121537 PMC 바로가기 [Article Type] Systematic Review
Heterologous humoral immunity to human and zoonotic coronaviruses: Aiming for the achilles heelReview Published on 2021-10-252023-06-15 Journal: Seminars in Immunology [Category] MERS, SARS, [키워드] antibodies Coronavirus disease 2019 (COVID-19) heterologous immunity Heterotypic immunity human coronaviruses Humoral immunity Immunological memory severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [DOI] 10.1016/j.smim.2021.101507 PMC 바로가기 [Article Type] Review
Protective heterologous T cell immunity in COVID-19 induced by the trivalent MMR and Tdap vaccine antigens3가 MMR 및 Tdap 백신 항원에 의해 유도된 COVID-19의 보호 이종 T 세포 면역Clinical and Translational Article Published on 2021-08-142022-09-14 Journal: Med (New York, N.Y.) [Category] MERS, SARS, 백일해, 임상, 진단, 치료기술, 치료법, [키워드] Abstract Activation acute respiratory syndrome Administered Analysis Anti-viral immunity Antibody titers Antigen antigen presenting cells antigens APC assays autologous CD45RA Cell co-cultured Cohort Context Control coronavirus coronavirus disease correlation COVID-19 COVID-19 patient COVID-19 patients COVID-19 vaccination cross-reactive death disease severity Donor driving Effect effective effector memory elicit ELISA ELISPOT ENhance enzyme-linked immunospot epitope feature Features finding flow cytometry foundation funding Heterologous heterologous immunity IFN-γ IL-15 Immunity implicated individual individuals Infection interferon-γ investigated memory memory T cells microbe mitigate MMR nucleocapsid outcomes overlapping Participants Pathogens phenotype promote PROTECT Protective Protein Reactivation recognizing reduced required response risk prediction SARS-CoV-2 SARS-CoV-2 antigen scRNA-seq severe COVID-19 Single-cell RNA sequencing subset supported T cell TCR TCR repertoire transcriptional Transcriptome trivalent uninfected vaccination Vaccine vaccine antigen Vaccines validation study viral infection with mild disease [DOI] 10.1016/j.medj.2021.08.004 PMC 바로가기 [Article Type] Clinical and Translational Article
COVID-19 Convalescent Plasma Is More than Neutralizing Antibodies: A Narrative Review of Potential Beneficial and Detrimental Co-FactorsCOVID-19 회복기 혈장은 중화 항체 이상입니다 : 잠재적 인 유익하고 유해한 공동 요인에 대한 이야기 검토Review Published on 2021-08-112022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] ADAMTS13 Alpha antibody affinity antithrombin III ARMS autoantibodies causal link CCP CCP therapy characterized Clinical efficacy component contribute controlled trials convalescent plasma COVID-19 COVID-19 convalescent plasma decoy receptors detrimental Effect Extracellular vesicles Factor fresh frozen plasma frozen plasma heterologous immunity highlight interferons MDA5 narrative Neutralizing antibodies neutralizing antibody outcome patients with COVID-19 plasma Potential Prophylaxis randomized clinical trial randomized clinical trials reported retrospective review Safe specific antibodies thrombosis Treatment variations [DOI] 10.3390/v13081594 PMC 바로가기 [Article Type] Review