Association between HLA-C alleles and COVID-19 severity in a pilot study with a Spanish Mediterranean Caucasian cohort스페인 지중해 백인 코호트를 대상으로 한 파일럿 연구에서 HLA-C 대립형질과 COVID-19 심각성 사이의 연관성Article Published on 2022-08-122022-09-11 Journal: PLoS ONE [Category] SARS, 유전자 메커니즘, [키워드] age allele analyzed antiviral response association Asymptomatic cause Cell cell surface class Clinical characteristics clinical presentation Clinical presentations Cohort Comorbidity contrary COVID-19 COVID-19 severity Critical described determine disease epitope Epitopes expressed Factor fatal disease Gender groups HLA HLA allele HLA alleles HLA class I HLA-A HLA-B HLA-B allele HLA-B alleles HLA-C HLA-C allele HLA-C alleles HLA-C1 Host hyperinflammatory state immune response individual Infection involved KIR gene male management mechanism Mild mild infection no significant difference no significant differences outcomes pandemic peptide peptides pilot study recruited SARS-CoV-2 protein SARS-CoV-2 proteins significant difference significant differences small sample size Spain Spanish T cells β2-microglobulin [DOI] 10.1371/journal.pone.0272867 PMC 바로가기 [Article Type] Article
The mutational landscape of SARS-CoV-2 variants diversifies T cell targets in an HLA-supertype-dependent mannerSARS-CoV-2 변이체의 돌연변이 환경은 HLA 수퍼타입 의존 방식으로 T 세포 표적을 다양화합니다Article Published on 2022-02-162022-09-11 Journal: Cell Systems [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] analyzed CD8 country COVID-19 delta variant dominant driven by epitope Epitopes expressing HLA HLA-B HLA-B allele HLA-B alleles Immunity immunodominant individual mass vaccination mutants Mutation pandemic peptide population level predicted prevalent proline proteome residue RNA SARS-CoV-2 SARS-CoV-2 genome assemblies SARS-CoV-2 variant supertype T cell T cell epitope T cell epitopes target vaccination variant variants [DOI] 10.1016/j.cels.2021.09.013 PMC 바로가기 [Article Type] Article
Predictive immunogenetic markers in COVID-19COVID-19의 예측 면역유전 마커Article Published on 2021-04-012022-09-11 Journal: Human immunology [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] affinity allele Case fatality rate CFR coronavirus disease Coronavirus disease 2019 correlated correlation correlations COVID-19 COVID-19 cytokine storm cytokine Cytokine polymorphisms Cytokines Daily data set DDR eight Ensembl Frequency functional genetic marker HLA-B HLA-B allele HLA-B alleles Host host genetics IL10 IL12B IL6 KIR KIR gene KIR genes KIR. marker nucleotide pandemic peptides polymorphism Polymorphisms Prognosis progression Rate rationale retrieved SARS-CoV-2 peptide SARS-CoV-2 peptides Single nucleotide polymorphism SNPs [DOI] 10.1016/j.humimm.2021.01.008 PMC 바로가기 [Article Type] Article
Association of MICA and HLA-B alleles with leprosy in two endemic populations in Brazilarticle Published on 2021-02-282024-09-01 Journal: International Journal of Immunogenetics [Category] 한센병, [키워드] Genetic polymorphism HLA-B alleles leprosy Linkage disequilibrium MICA alleles [Article Type] article